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Fusion gene ID: 2988 |
FusionGeneSummary for ASH2L_ZFYVE28 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ASH2L_ZFYVE28 | Fusion gene ID: 2988 | Hgene | Tgene | Gene symbol | ASH2L | ZFYVE28 | Gene ID | 9070 | 57732 |
| Gene name | ASH2 like, histone lysine methyltransferase complex subunit | zinc finger FYVE-type containing 28 | |
| Synonyms | ASH2|ASH2L1|ASH2L2|Bre2 | LST2|LYST2 | |
| Cytomap | 8p11.23 | 4p16.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | set1/Ash2 histone methyltransferase complex subunit ASH2ASH2-like proteinash2 (absent, small, or homeotic)-like | lateral signaling target protein 2 homologhLst2zinc finger FYVE domain-containing protein 28zinc finger, FYVE domain containing 28 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9UBL3 | Q9HCC9 | |
| Ensembl transtripts involved in fusion gene | ENST00000343823, ENST00000250635, ENST00000545394, ENST00000428278, ENST00000521652, ENST00000524263, | ENST00000290974, ENST00000511071, ENST00000515312, ENST00000515169, ENST00000509171, ENST00000503000, ENST00000508471, ENST00000505421, | |
| Fusion gene scores | * DoF score | 8 X 6 X 5=240 | 8 X 6 X 7=336 |
| # samples | 8 | 8 | |
| ** MAII score | log2(8/240*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/336*10)=-2.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ASH2L [Title/Abstract] AND ZFYVE28 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ASH2L | GO:0006974 | cellular response to DNA damage stimulus | 17500065 |
| Hgene | ASH2L | GO:0043627 | response to estrogen | 16603732 |
| Hgene | ASH2L | GO:0051568 | histone H3-K4 methylation | 17355966|19556245 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-LL-A7T0-01A | ASH2L | chr8 | 37976881 | + | ZFYVE28 | chr4 | 2343342 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000343823 | ENST00000290974 | ASH2L | chr8 | 37976881 | + | ZFYVE28 | chr4 | 2343342 | - |
| Frame-shift | ENST00000343823 | ENST00000511071 | ASH2L | chr8 | 37976881 | + | ZFYVE28 | chr4 | 2343342 | - |
| 5CDS-5UTR | ENST00000343823 | ENST00000515312 | ASH2L | chr8 | 37976881 | + | ZFYVE28 | chr4 | 2343342 | - |
| 5CDS-5UTR | ENST00000343823 | ENST00000515169 | ASH2L | chr8 | 37976881 | + | ZFYVE28 | chr4 | 2343342 | - |
| 5CDS-5UTR | ENST00000343823 | ENST00000509171 | ASH2L | chr8 | 37976881 | + | ZFYVE28 | chr4 | 2343342 | - |
| 5CDS-5UTR | ENST00000343823 | ENST00000503000 | ASH2L | chr8 | 37976881 | + | ZFYVE28 | chr4 | 2343342 | - |
| 5CDS-intron | ENST00000343823 | ENST00000508471 | ASH2L | chr8 | 37976881 | + | ZFYVE28 | chr4 | 2343342 | - |
| 5CDS-intron | ENST00000343823 | ENST00000505421 | ASH2L | chr8 | 37976881 | + | ZFYVE28 | chr4 | 2343342 | - |
| Frame-shift | ENST00000250635 | ENST00000290974 | ASH2L | chr8 | 37976881 | + | ZFYVE28 | chr4 | 2343342 | - |
| Frame-shift | ENST00000250635 | ENST00000511071 | ASH2L | chr8 | 37976881 | + | ZFYVE28 | chr4 | 2343342 | - |
| 5CDS-5UTR | ENST00000250635 | ENST00000515312 | ASH2L | chr8 | 37976881 | + | ZFYVE28 | chr4 | 2343342 | - |
| 5CDS-5UTR | ENST00000250635 | ENST00000515169 | ASH2L | chr8 | 37976881 | + | ZFYVE28 | chr4 | 2343342 | - |
| 5CDS-5UTR | ENST00000250635 | ENST00000509171 | ASH2L | chr8 | 37976881 | + | ZFYVE28 | chr4 | 2343342 | - |
| 5CDS-5UTR | ENST00000250635 | ENST00000503000 | ASH2L | chr8 | 37976881 | + | ZFYVE28 | chr4 | 2343342 | - |
| 5CDS-intron | ENST00000250635 | ENST00000508471 | ASH2L | chr8 | 37976881 | + | ZFYVE28 | chr4 | 2343342 | - |
| 5CDS-intron | ENST00000250635 | ENST00000505421 | ASH2L | chr8 | 37976881 | + | ZFYVE28 | chr4 | 2343342 | - |
| Frame-shift | ENST00000545394 | ENST00000290974 | ASH2L | chr8 | 37976881 | + | ZFYVE28 | chr4 | 2343342 | - |
| Frame-shift | ENST00000545394 | ENST00000511071 | ASH2L | chr8 | 37976881 | + | ZFYVE28 | chr4 | 2343342 | - |
| 5CDS-5UTR | ENST00000545394 | ENST00000515312 | ASH2L | chr8 | 37976881 | + | ZFYVE28 | chr4 | 2343342 | - |
| 5CDS-5UTR | ENST00000545394 | ENST00000515169 | ASH2L | chr8 | 37976881 | + | ZFYVE28 | chr4 | 2343342 | - |
| 5CDS-5UTR | ENST00000545394 | ENST00000509171 | ASH2L | chr8 | 37976881 | + | ZFYVE28 | chr4 | 2343342 | - |
| 5CDS-5UTR | ENST00000545394 | ENST00000503000 | ASH2L | chr8 | 37976881 | + | ZFYVE28 | chr4 | 2343342 | - |
| 5CDS-intron | ENST00000545394 | ENST00000508471 | ASH2L | chr8 | 37976881 | + | ZFYVE28 | chr4 | 2343342 | - |
| 5CDS-intron | ENST00000545394 | ENST00000505421 | ASH2L | chr8 | 37976881 | + | ZFYVE28 | chr4 | 2343342 | - |
| Frame-shift | ENST00000428278 | ENST00000290974 | ASH2L | chr8 | 37976881 | + | ZFYVE28 | chr4 | 2343342 | - |
| Frame-shift | ENST00000428278 | ENST00000511071 | ASH2L | chr8 | 37976881 | + | ZFYVE28 | chr4 | 2343342 | - |
| 5CDS-5UTR | ENST00000428278 | ENST00000515312 | ASH2L | chr8 | 37976881 | + | ZFYVE28 | chr4 | 2343342 | - |
| 5CDS-5UTR | ENST00000428278 | ENST00000515169 | ASH2L | chr8 | 37976881 | + | ZFYVE28 | chr4 | 2343342 | - |
| 5CDS-5UTR | ENST00000428278 | ENST00000509171 | ASH2L | chr8 | 37976881 | + | ZFYVE28 | chr4 | 2343342 | - |
| 5CDS-5UTR | ENST00000428278 | ENST00000503000 | ASH2L | chr8 | 37976881 | + | ZFYVE28 | chr4 | 2343342 | - |
| 5CDS-intron | ENST00000428278 | ENST00000508471 | ASH2L | chr8 | 37976881 | + | ZFYVE28 | chr4 | 2343342 | - |
| 5CDS-intron | ENST00000428278 | ENST00000505421 | ASH2L | chr8 | 37976881 | + | ZFYVE28 | chr4 | 2343342 | - |
| Frame-shift | ENST00000521652 | ENST00000290974 | ASH2L | chr8 | 37976881 | + | ZFYVE28 | chr4 | 2343342 | - |
| Frame-shift | ENST00000521652 | ENST00000511071 | ASH2L | chr8 | 37976881 | + | ZFYVE28 | chr4 | 2343342 | - |
| 5CDS-5UTR | ENST00000521652 | ENST00000515312 | ASH2L | chr8 | 37976881 | + | ZFYVE28 | chr4 | 2343342 | - |
| 5CDS-5UTR | ENST00000521652 | ENST00000515169 | ASH2L | chr8 | 37976881 | + | ZFYVE28 | chr4 | 2343342 | - |
| 5CDS-5UTR | ENST00000521652 | ENST00000509171 | ASH2L | chr8 | 37976881 | + | ZFYVE28 | chr4 | 2343342 | - |
| 5CDS-5UTR | ENST00000521652 | ENST00000503000 | ASH2L | chr8 | 37976881 | + | ZFYVE28 | chr4 | 2343342 | - |
| 5CDS-intron | ENST00000521652 | ENST00000508471 | ASH2L | chr8 | 37976881 | + | ZFYVE28 | chr4 | 2343342 | - |
| 5CDS-intron | ENST00000521652 | ENST00000505421 | ASH2L | chr8 | 37976881 | + | ZFYVE28 | chr4 | 2343342 | - |
| intron-3CDS | ENST00000524263 | ENST00000290974 | ASH2L | chr8 | 37976881 | + | ZFYVE28 | chr4 | 2343342 | - |
| intron-3CDS | ENST00000524263 | ENST00000511071 | ASH2L | chr8 | 37976881 | + | ZFYVE28 | chr4 | 2343342 | - |
| intron-5UTR | ENST00000524263 | ENST00000515312 | ASH2L | chr8 | 37976881 | + | ZFYVE28 | chr4 | 2343342 | - |
| intron-5UTR | ENST00000524263 | ENST00000515169 | ASH2L | chr8 | 37976881 | + | ZFYVE28 | chr4 | 2343342 | - |
| intron-5UTR | ENST00000524263 | ENST00000509171 | ASH2L | chr8 | 37976881 | + | ZFYVE28 | chr4 | 2343342 | - |
| intron-5UTR | ENST00000524263 | ENST00000503000 | ASH2L | chr8 | 37976881 | + | ZFYVE28 | chr4 | 2343342 | - |
| intron-intron | ENST00000524263 | ENST00000508471 | ASH2L | chr8 | 37976881 | + | ZFYVE28 | chr4 | 2343342 | - |
| intron-intron | ENST00000524263 | ENST00000505421 | ASH2L | chr8 | 37976881 | + | ZFYVE28 | chr4 | 2343342 | - |
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FusionProtFeatures for ASH2L_ZFYVE28 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ASH2L | ZFYVE28 |