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Fusion gene ID: 29845 |
FusionGeneSummary for R3HDM2_NFE2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: R3HDM2_NFE2 | Fusion gene ID: 29845 | Hgene | Tgene | Gene symbol | R3HDM2 | NFE2 | Gene ID | 22864 | 4778 |
| Gene name | R3H domain containing 2 | nuclear factor, erythroid 2 | |
| Synonyms | CAG6|PR01365 | NF-E2|p45 | |
| Cytomap | 12q13.3 | 12q13.13 | |
| Type of gene | protein-coding | protein-coding | |
| Description | R3H domain-containing protein 2 | transcription factor NF-E2 45 kDa subunitleucine zipper protein NF-E2nuclear factor (erythroid-derived 2), 45kDnuclear factor (erythroid-derived 2), 45kDanuclear factor, erythroid-derived 2 45 kDa subunitp45 NF-E2 | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q9Y2K5 | Q16621 | |
| Ensembl transtripts involved in fusion gene | ENST00000413953, ENST00000347140, ENST00000358907, ENST00000402412, ENST00000441731, ENST00000403821, ENST00000546843, | ENST00000312156, ENST00000435572, ENST00000540264, ENST00000553070, | |
| Fusion gene scores | * DoF score | 29 X 12 X 9=3132 | 4 X 2 X 5=40 |
| # samples | 28 | 5 | |
| ** MAII score | log2(28/3132*10)=-3.48358548034607 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/40*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: R3HDM2 [Title/Abstract] AND NFE2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | GU068583 | R3HDM2 | chr12 | 57789530 | - | NFE2 | chr12 | 54689091 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-5UTR | ENST00000413953 | ENST00000312156 | R3HDM2 | chr12 | 57789530 | - | NFE2 | chr12 | 54689091 | - |
| intron-5UTR | ENST00000413953 | ENST00000435572 | R3HDM2 | chr12 | 57789530 | - | NFE2 | chr12 | 54689091 | - |
| intron-5UTR | ENST00000413953 | ENST00000540264 | R3HDM2 | chr12 | 57789530 | - | NFE2 | chr12 | 54689091 | - |
| intron-5UTR | ENST00000413953 | ENST00000553070 | R3HDM2 | chr12 | 57789530 | - | NFE2 | chr12 | 54689091 | - |
| 5UTR-5UTR | ENST00000347140 | ENST00000312156 | R3HDM2 | chr12 | 57789530 | - | NFE2 | chr12 | 54689091 | - |
| 5UTR-5UTR | ENST00000347140 | ENST00000435572 | R3HDM2 | chr12 | 57789530 | - | NFE2 | chr12 | 54689091 | - |
| 5UTR-5UTR | ENST00000347140 | ENST00000540264 | R3HDM2 | chr12 | 57789530 | - | NFE2 | chr12 | 54689091 | - |
| 5UTR-5UTR | ENST00000347140 | ENST00000553070 | R3HDM2 | chr12 | 57789530 | - | NFE2 | chr12 | 54689091 | - |
| intron-5UTR | ENST00000358907 | ENST00000312156 | R3HDM2 | chr12 | 57789530 | - | NFE2 | chr12 | 54689091 | - |
| intron-5UTR | ENST00000358907 | ENST00000435572 | R3HDM2 | chr12 | 57789530 | - | NFE2 | chr12 | 54689091 | - |
| intron-5UTR | ENST00000358907 | ENST00000540264 | R3HDM2 | chr12 | 57789530 | - | NFE2 | chr12 | 54689091 | - |
| intron-5UTR | ENST00000358907 | ENST00000553070 | R3HDM2 | chr12 | 57789530 | - | NFE2 | chr12 | 54689091 | - |
| 5UTR-5UTR | ENST00000402412 | ENST00000312156 | R3HDM2 | chr12 | 57789530 | - | NFE2 | chr12 | 54689091 | - |
| 5UTR-5UTR | ENST00000402412 | ENST00000435572 | R3HDM2 | chr12 | 57789530 | - | NFE2 | chr12 | 54689091 | - |
| 5UTR-5UTR | ENST00000402412 | ENST00000540264 | R3HDM2 | chr12 | 57789530 | - | NFE2 | chr12 | 54689091 | - |
| 5UTR-5UTR | ENST00000402412 | ENST00000553070 | R3HDM2 | chr12 | 57789530 | - | NFE2 | chr12 | 54689091 | - |
| intron-5UTR | ENST00000441731 | ENST00000312156 | R3HDM2 | chr12 | 57789530 | - | NFE2 | chr12 | 54689091 | - |
| intron-5UTR | ENST00000441731 | ENST00000435572 | R3HDM2 | chr12 | 57789530 | - | NFE2 | chr12 | 54689091 | - |
| intron-5UTR | ENST00000441731 | ENST00000540264 | R3HDM2 | chr12 | 57789530 | - | NFE2 | chr12 | 54689091 | - |
| intron-5UTR | ENST00000441731 | ENST00000553070 | R3HDM2 | chr12 | 57789530 | - | NFE2 | chr12 | 54689091 | - |
| intron-5UTR | ENST00000403821 | ENST00000312156 | R3HDM2 | chr12 | 57789530 | - | NFE2 | chr12 | 54689091 | - |
| intron-5UTR | ENST00000403821 | ENST00000435572 | R3HDM2 | chr12 | 57789530 | - | NFE2 | chr12 | 54689091 | - |
| intron-5UTR | ENST00000403821 | ENST00000540264 | R3HDM2 | chr12 | 57789530 | - | NFE2 | chr12 | 54689091 | - |
| intron-5UTR | ENST00000403821 | ENST00000553070 | R3HDM2 | chr12 | 57789530 | - | NFE2 | chr12 | 54689091 | - |
| intron-5UTR | ENST00000546843 | ENST00000312156 | R3HDM2 | chr12 | 57789530 | - | NFE2 | chr12 | 54689091 | - |
| intron-5UTR | ENST00000546843 | ENST00000435572 | R3HDM2 | chr12 | 57789530 | - | NFE2 | chr12 | 54689091 | - |
| intron-5UTR | ENST00000546843 | ENST00000540264 | R3HDM2 | chr12 | 57789530 | - | NFE2 | chr12 | 54689091 | - |
| intron-5UTR | ENST00000546843 | ENST00000553070 | R3HDM2 | chr12 | 57789530 | - | NFE2 | chr12 | 54689091 | - |
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FusionProtFeatures for R3HDM2_NFE2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| R3HDM2 | NFE2 |