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Fusion gene ID: 29828 |
FusionGeneSummary for R3HCC1_GRIK5 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: R3HCC1_GRIK5 | Fusion gene ID: 29828 | Hgene | Tgene | Gene symbol | R3HCC1 | GRIK5 | Gene ID | 203069 | 2901 |
| Gene name | R3H domain and coiled-coil containing 1 | glutamate ionotropic receptor kainate type subunit 5 | |
| Synonyms | - | EAA2|GRIK2|GluK5|KA2 | |
| Cytomap | 8p21.3 | 19q13.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | R3H and coiled-coil domain-containing protein 1 | glutamate receptor ionotropic, kainate 5excitatory amino acid receptor 2glutamate receptor KA2 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9Y3T6 | Q16478 | |
| Ensembl transtripts involved in fusion gene | ENST00000522012, ENST00000518454, ENST00000265806, ENST00000411463, | ENST00000262895, ENST00000593562, ENST00000301218, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 3 X 3 X 3=27 |
| # samples | 2 | 3 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: R3HCC1 [Title/Abstract] AND GRIK5 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | ESCA | TCGA-L5-A891-01A | R3HCC1 | chr8 | 23147982 | + | GRIK5 | chr19 | 42526506 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 3UTR-3CDS | ENST00000522012 | ENST00000262895 | R3HCC1 | chr8 | 23147982 | + | GRIK5 | chr19 | 42526506 | - |
| 3UTR-3CDS | ENST00000522012 | ENST00000593562 | R3HCC1 | chr8 | 23147982 | + | GRIK5 | chr19 | 42526506 | - |
| 3UTR-3CDS | ENST00000522012 | ENST00000301218 | R3HCC1 | chr8 | 23147982 | + | GRIK5 | chr19 | 42526506 | - |
| In-frame | ENST00000518454 | ENST00000262895 | R3HCC1 | chr8 | 23147982 | + | GRIK5 | chr19 | 42526506 | - |
| In-frame | ENST00000518454 | ENST00000593562 | R3HCC1 | chr8 | 23147982 | + | GRIK5 | chr19 | 42526506 | - |
| In-frame | ENST00000518454 | ENST00000301218 | R3HCC1 | chr8 | 23147982 | + | GRIK5 | chr19 | 42526506 | - |
| In-frame | ENST00000265806 | ENST00000262895 | R3HCC1 | chr8 | 23147982 | + | GRIK5 | chr19 | 42526506 | - |
| In-frame | ENST00000265806 | ENST00000593562 | R3HCC1 | chr8 | 23147982 | + | GRIK5 | chr19 | 42526506 | - |
| In-frame | ENST00000265806 | ENST00000301218 | R3HCC1 | chr8 | 23147982 | + | GRIK5 | chr19 | 42526506 | - |
| In-frame | ENST00000411463 | ENST00000262895 | R3HCC1 | chr8 | 23147982 | + | GRIK5 | chr19 | 42526506 | - |
| In-frame | ENST00000411463 | ENST00000593562 | R3HCC1 | chr8 | 23147982 | + | GRIK5 | chr19 | 42526506 | - |
| In-frame | ENST00000411463 | ENST00000301218 | R3HCC1 | chr8 | 23147982 | + | GRIK5 | chr19 | 42526506 | - |
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FusionProtFeatures for R3HCC1_GRIK5 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| R3HCC1 | GRIK5 |