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Fusion gene ID: 29777 |
FusionGeneSummary for PYGB_CNBD2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PYGB_CNBD2 | Fusion gene ID: 29777 | Hgene | Tgene | Gene symbol | PYGB | CNBD2 | Gene ID | 5834 | 140894 |
| Gene name | glycogen phosphorylase B | cyclic nucleotide binding domain containing 2 | |
| Synonyms | GPBB | C20orf152|CNMPD1 | |
| Cytomap | 20p11.21 | 20q11.23 | |
| Type of gene | protein-coding | protein-coding | |
| Description | glycogen phosphorylase, brain formphosphorylase, glycogen; brain | cyclic nucleotide-binding domain-containing protein 2cyclic nucleotide (cNMP) binding domain containing 1 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P11216 | Q96M20 | |
| Ensembl transtripts involved in fusion gene | ENST00000216962, ENST00000471359, | ENST00000373973, ENST00000349339, ENST00000538900, | |
| Fusion gene scores | * DoF score | 6 X 6 X 4=144 | 9 X 6 X 9=486 |
| # samples | 6 | 11 | |
| ** MAII score | log2(6/144*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(11/486*10)=-2.14345279008112 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: PYGB [Title/Abstract] AND CNBD2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | COAD | TCGA-AA-3660-01A | PYGB | chr20 | 25273249 | + | CNBD2 | chr20 | 34575317 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000216962 | ENST00000373973 | PYGB | chr20 | 25273249 | + | CNBD2 | chr20 | 34575317 | + |
| In-frame | ENST00000216962 | ENST00000349339 | PYGB | chr20 | 25273249 | + | CNBD2 | chr20 | 34575317 | + |
| In-frame | ENST00000216962 | ENST00000538900 | PYGB | chr20 | 25273249 | + | CNBD2 | chr20 | 34575317 | + |
| intron-3CDS | ENST00000471359 | ENST00000373973 | PYGB | chr20 | 25273249 | + | CNBD2 | chr20 | 34575317 | + |
| intron-3CDS | ENST00000471359 | ENST00000349339 | PYGB | chr20 | 25273249 | + | CNBD2 | chr20 | 34575317 | + |
| intron-3CDS | ENST00000471359 | ENST00000538900 | PYGB | chr20 | 25273249 | + | CNBD2 | chr20 | 34575317 | + |
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FusionProtFeatures for PYGB_CNBD2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PYGB | CNBD2 |