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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 29705

FusionGeneSummary for PVR_SIRT2

check button Fusion gene summary
Fusion gene informationFusion gene name: PVR_SIRT2
Fusion gene ID: 29705
HgeneTgene
Gene symbol

PVR

SIRT2

Gene ID

5817

22933

Gene namepoliovirus receptorsirtuin 2
SynonymsCD155|HVED|NECL5|Necl-5|PVS|TAGE4SIR2|SIR2L|SIR2L2
Cytomap

19q13.31

19q13.2

Type of geneprotein-codingprotein-coding
Descriptionpoliovirus receptornectin-like protein 5NAD-dependent protein deacetylase sirtuin-2NAD-dependent deacetylase sirtuin-2SIR2-like protein 2regulatory protein SIR2 homolog 2silent information regulator 2sir2-related protein type 2sirtuin type 2
Modification date2018052320180527
UniProtAcc

P15151

Q8IXJ6

Ensembl transtripts involved in fusion geneENST00000425690, ENST00000344956, 
ENST00000403059, ENST00000406449, 
ENST00000249396, ENST00000392081, 
ENST00000358931, ENST00000481381, 
Fusion gene scores* DoF score7 X 7 X 5=2454 X 3 X 4=48
# samples 74
** MAII scorelog2(7/245*10)=-1.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PVR [Title/Abstract] AND SIRT2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, in-frame but not retained their domain.
Tumor suppressor gene involved fusion gene, retained protein feature but frameshift.
DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePVR

GO:0060370

susceptibility to T cell mediated cytotoxicity

15039383

TgeneSIRT2

GO:0000122

negative regulation of transcription by RNA polymerase II

18722353

TgeneSIRT2

GO:0006476

protein deacetylation

17172643|20543840|21949390

TgeneSIRT2

GO:0034983

peptidyl-lysine deacetylation

23932781

TgeneSIRT2

GO:0035729

cellular response to hepatocyte growth factor stimulus

23908241

TgeneSIRT2

GO:0045843

negative regulation of striated muscle tissue development

12887892

TgeneSIRT2

GO:0045892

negative regulation of transcription, DNA-templated

12887892

TgeneSIRT2

GO:0048012

hepatocyte growth factor receptor signaling pathway

23908241

TgeneSIRT2

GO:0070933

histone H4 deacetylation

16648462|17488717

TgeneSIRT2

GO:0071219

cellular response to molecule of bacterial origin

23908241

TgeneSIRT2

GO:0071456

cellular response to hypoxia

24681946

TgeneSIRT2

GO:0090042

tubulin deacetylation

18722353|23886946


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVUCSTCGA-N7-A4Y8-01APVRchr19

45147475

+SIRT2chr19

39372131

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000425690ENST00000249396PVRchr19

45147475

+SIRT2chr19

39372131

-
In-frameENST00000425690ENST00000392081PVRchr19

45147475

+SIRT2chr19

39372131

-
In-frameENST00000425690ENST00000358931PVRchr19

45147475

+SIRT2chr19

39372131

-
5CDS-intronENST00000425690ENST00000481381PVRchr19

45147475

+SIRT2chr19

39372131

-
In-frameENST00000344956ENST00000249396PVRchr19

45147475

+SIRT2chr19

39372131

-
In-frameENST00000344956ENST00000392081PVRchr19

45147475

+SIRT2chr19

39372131

-
In-frameENST00000344956ENST00000358931PVRchr19

45147475

+SIRT2chr19

39372131

-
5CDS-intronENST00000344956ENST00000481381PVRchr19

45147475

+SIRT2chr19

39372131

-
In-frameENST00000403059ENST00000249396PVRchr19

45147475

+SIRT2chr19

39372131

-
In-frameENST00000403059ENST00000392081PVRchr19

45147475

+SIRT2chr19

39372131

-
In-frameENST00000403059ENST00000358931PVRchr19

45147475

+SIRT2chr19

39372131

-
5CDS-intronENST00000403059ENST00000481381PVRchr19

45147475

+SIRT2chr19

39372131

-
In-frameENST00000406449ENST00000249396PVRchr19

45147475

+SIRT2chr19

39372131

-
In-frameENST00000406449ENST00000392081PVRchr19

45147475

+SIRT2chr19

39372131

-
In-frameENST00000406449ENST00000358931PVRchr19

45147475

+SIRT2chr19

39372131

-
5CDS-intronENST00000406449ENST00000481381PVRchr19

45147475

+SIRT2chr19

39372131

-

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FusionProtFeatures for PVR_SIRT2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PVR

P15151

SIRT2

Q8IXJ6

Mediates NK cell adhesion and triggers NK cell effectorfunctions. Binds two different NK cell receptors: CD96 and CD226.These interactions accumulates at the cell-cell contact site,leading to the formation of a mature immunological synapse betweenNK cell and target cell. This may trigger adhesion and secretionof lytic granules and IFN-gamma and activate cytoxicity ofactivated NK cells. May also promote NK cell-target cell modularexchange, and PVR transfer to the NK cell. This transfer is moreimportant in some tumor cells expressing a lot of PVR, and maytrigger fratricide NK cell activation, providing tumors with amechanism of immunoevasion. Plays a role in mediating tumor cellinvasion and migration. {ECO:0000269|PubMed:15471548,ECO:0000269|PubMed:15607800}. (Microbial infection) Acts as a receptor for poliovirus.May play a role in axonal transport of poliovirus, by targetingvirion-PVR-containing endocytic vesicles to the microtubularnetwork through interaction with DYNLT1. This interaction woulddrive the virus-containing vesicle to the axonal retrogradetransport. {ECO:0000269|PubMed:2538245}. (Microbial infection) Acts as a receptor forPseudorabies virus. {ECO:0000269|PubMed:9616127}. (Microbial infection) Is prevented to reach cell surfaceupon infection by Human cytomegalovirus /HHV-5, presumably toescape immune recognition of infected cell by NK cells.{ECO:0000269|PubMed:15640804}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSIRT2chr19:45147475chr19:39372131ENST00000249396-816262_263210390Nucleotide bindingNAD
TgeneSIRT2chr19:45147475chr19:39372131ENST00000249396-816286_288210390Nucleotide bindingNAD
TgeneSIRT2chr19:45147475chr19:39372131ENST00000358931-814262_263210452Nucleotide bindingNAD
TgeneSIRT2chr19:45147475chr19:39372131ENST00000358931-814286_288210452Nucleotide bindingNAD
TgeneSIRT2chr19:45147475chr19:39372131ENST00000392081-715262_263173353Nucleotide bindingNAD
TgeneSIRT2chr19:45147475chr19:39372131ENST00000392081-715286_288173353Nucleotide bindingNAD
TgeneSIRT2chr19:45147475chr19:39372131ENST00000249396-816232_301210390RegionNote=Peptide inhibitor binding
TgeneSIRT2chr19:45147475chr19:39372131ENST00000358931-814232_301210452RegionNote=Peptide inhibitor binding
TgeneSIRT2chr19:45147475chr19:39372131ENST00000392081-715232_301173353RegionNote=Peptide inhibitor binding

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePVRchr19:45147475chr19:39372131ENST00000344956+17145_23726365DomainNote=Ig-like C2-type 1
HgenePVRchr19:45147475chr19:39372131ENST00000344956+17244_32826365DomainNote=Ig-like C2-type 2
HgenePVRchr19:45147475chr19:39372131ENST00000344956+1724_13926365DomainNote=Ig-like V-type
HgenePVRchr19:45147475chr19:39372131ENST00000403059+18145_23726373DomainNote=Ig-like C2-type 1
HgenePVRchr19:45147475chr19:39372131ENST00000403059+18244_32826373DomainNote=Ig-like C2-type 2
HgenePVRchr19:45147475chr19:39372131ENST00000403059+1824_13926373DomainNote=Ig-like V-type
HgenePVRchr19:45147475chr19:39372131ENST00000406449+16145_23726393DomainNote=Ig-like C2-type 1
HgenePVRchr19:45147475chr19:39372131ENST00000406449+16244_32826393DomainNote=Ig-like C2-type 2
HgenePVRchr19:45147475chr19:39372131ENST00000406449+1624_13926393DomainNote=Ig-like V-type
HgenePVRchr19:45147475chr19:39372131ENST00000425690+18145_23726418DomainNote=Ig-like C2-type 1
HgenePVRchr19:45147475chr19:39372131ENST00000425690+18244_32826418DomainNote=Ig-like C2-type 2
HgenePVRchr19:45147475chr19:39372131ENST00000425690+1824_13926418DomainNote=Ig-like V-type
HgenePVRchr19:45147475chr19:39372131ENST00000344956+17396_40126365MotifNote=ITIM motif
HgenePVRchr19:45147475chr19:39372131ENST00000403059+18396_40126373MotifNote=ITIM motif
HgenePVRchr19:45147475chr19:39372131ENST00000406449+16396_40126393MotifNote=ITIM motif
HgenePVRchr19:45147475chr19:39372131ENST00000425690+18396_40126418MotifNote=ITIM motif
HgenePVRchr19:45147475chr19:39372131ENST00000344956+17368_37226365RegionNote=DYNLT1 binding
HgenePVRchr19:45147475chr19:39372131ENST00000403059+18368_37226373RegionNote=DYNLT1 binding
HgenePVRchr19:45147475chr19:39372131ENST00000406449+16368_37226393RegionNote=DYNLT1 binding
HgenePVRchr19:45147475chr19:39372131ENST00000425690+18368_37226418RegionNote=DYNLT1 binding
HgenePVRchr19:45147475chr19:39372131ENST00000344956+1721_34326365Topological domainExtracellular
HgenePVRchr19:45147475chr19:39372131ENST00000344956+17368_41726365Topological domainCytoplasmic
HgenePVRchr19:45147475chr19:39372131ENST00000403059+1821_34326373Topological domainExtracellular
HgenePVRchr19:45147475chr19:39372131ENST00000403059+18368_41726373Topological domainCytoplasmic
HgenePVRchr19:45147475chr19:39372131ENST00000406449+1621_34326393Topological domainExtracellular
HgenePVRchr19:45147475chr19:39372131ENST00000406449+16368_41726393Topological domainCytoplasmic
HgenePVRchr19:45147475chr19:39372131ENST00000425690+1821_34326418Topological domainExtracellular
HgenePVRchr19:45147475chr19:39372131ENST00000425690+18368_41726418Topological domainCytoplasmic
HgenePVRchr19:45147475chr19:39372131ENST00000344956+17344_36726365TransmembraneHelical
HgenePVRchr19:45147475chr19:39372131ENST00000403059+18344_36726373TransmembraneHelical
HgenePVRchr19:45147475chr19:39372131ENST00000406449+16344_36726393TransmembraneHelical
HgenePVRchr19:45147475chr19:39372131ENST00000425690+18344_36726418TransmembraneHelical
TgeneSIRT2chr19:45147475chr19:39372131ENST00000249396-81665_340210390DomainDeacetylase sirtuin-type
TgeneSIRT2chr19:45147475chr19:39372131ENST00000358931-81465_340210452DomainDeacetylase sirtuin-type
TgeneSIRT2chr19:45147475chr19:39372131ENST00000392081-71565_340173353DomainDeacetylase sirtuin-type
TgeneSIRT2chr19:45147475chr19:39372131ENST00000249396-81641_51210390MotifNote=Nuclear export signal
TgeneSIRT2chr19:45147475chr19:39372131ENST00000358931-81441_51210452MotifNote=Nuclear export signal
TgeneSIRT2chr19:45147475chr19:39372131ENST00000392081-71541_51173353MotifNote=Nuclear export signal
TgeneSIRT2chr19:45147475chr19:39372131ENST00000249396-816167_170210390Nucleotide bindingNAD
TgeneSIRT2chr19:45147475chr19:39372131ENST00000249396-81685_89210390Nucleotide bindingNAD
TgeneSIRT2chr19:45147475chr19:39372131ENST00000249396-81695_97210390Nucleotide bindingNAD
TgeneSIRT2chr19:45147475chr19:39372131ENST00000358931-814167_170210452Nucleotide bindingNAD
TgeneSIRT2chr19:45147475chr19:39372131ENST00000358931-81485_89210452Nucleotide bindingNAD
TgeneSIRT2chr19:45147475chr19:39372131ENST00000358931-81495_97210452Nucleotide bindingNAD
TgeneSIRT2chr19:45147475chr19:39372131ENST00000392081-715167_170173353Nucleotide bindingNAD
TgeneSIRT2chr19:45147475chr19:39372131ENST00000392081-71585_89173353Nucleotide bindingNAD
TgeneSIRT2chr19:45147475chr19:39372131ENST00000392081-71595_97173353Nucleotide bindingNAD
TgeneSIRT2chr19:45147475chr19:39372131ENST00000249396-816116_120210390RegionNote=Peptide inhibitor binding
TgeneSIRT2chr19:45147475chr19:39372131ENST00000358931-814116_120210452RegionNote=Peptide inhibitor binding
TgeneSIRT2chr19:45147475chr19:39372131ENST00000392081-715116_120173353RegionNote=Peptide inhibitor binding


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FusionGeneSequence for PVR_SIRT2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_PVR_ENST00000425690_chr19_45147475_+_SIRT2_ENST00000249396_chr19_39372131_-_206aa
MARAMAAAWPLLLVALLVLSWPPPGTEKIFSEVTPKCEDCQSLVKPDIVFFGESLPARFFSCMQSDFLKVDLLLVMGTSLQVQPFASLIS
KAPLSTPRLLINKEKAGQSDPFLGMIMGLGGGMDFDSKKAYRDVAWLGECDQGCLALAELLGWKKELEDLVRREHASIDAQSGAGVPNPS

>In-frame_PVR_ENST00000425690_chr19_45147475_+_SIRT2_ENST00000392081_chr19_39372131_-_206aa
MARAMAAAWPLLLVALLVLSWPPPGTEKIFSEVTPKCEDCQSLVKPDIVFFGESLPARFFSCMQSDFLKVDLLLVMGTSLQVQPFASLIS
KAPLSTPRLLINKEKAGQSDPFLGMIMGLGGGMDFDSKKAYRDVAWLGECDQGCLALAELLGWKKELEDLVRREHASIDAQSGAGVPNPS

>In-frame_PVR_ENST00000425690_chr19_45147475_+_SIRT2_ENST00000358931_chr19_39372131_-_88aa

>In-frame_PVR_ENST00000344956_chr19_45147475_+_SIRT2_ENST00000249396_chr19_39372131_-_206aa
MARAMAAAWPLLLVALLVLSWPPPGTEKIFSEVTPKCEDCQSLVKPDIVFFGESLPARFFSCMQSDFLKVDLLLVMGTSLQVQPFASLIS
KAPLSTPRLLINKEKAGQSDPFLGMIMGLGGGMDFDSKKAYRDVAWLGECDQGCLALAELLGWKKELEDLVRREHASIDAQSGAGVPNPS

>In-frame_PVR_ENST00000344956_chr19_45147475_+_SIRT2_ENST00000392081_chr19_39372131_-_206aa
MARAMAAAWPLLLVALLVLSWPPPGTEKIFSEVTPKCEDCQSLVKPDIVFFGESLPARFFSCMQSDFLKVDLLLVMGTSLQVQPFASLIS
KAPLSTPRLLINKEKAGQSDPFLGMIMGLGGGMDFDSKKAYRDVAWLGECDQGCLALAELLGWKKELEDLVRREHASIDAQSGAGVPNPS

>In-frame_PVR_ENST00000344956_chr19_45147475_+_SIRT2_ENST00000358931_chr19_39372131_-_88aa

>In-frame_PVR_ENST00000403059_chr19_45147475_+_SIRT2_ENST00000249396_chr19_39372131_-_206aa
MARAMAAAWPLLLVALLVLSWPPPGTEKIFSEVTPKCEDCQSLVKPDIVFFGESLPARFFSCMQSDFLKVDLLLVMGTSLQVQPFASLIS
KAPLSTPRLLINKEKAGQSDPFLGMIMGLGGGMDFDSKKAYRDVAWLGECDQGCLALAELLGWKKELEDLVRREHASIDAQSGAGVPNPS

>In-frame_PVR_ENST00000403059_chr19_45147475_+_SIRT2_ENST00000392081_chr19_39372131_-_206aa
MARAMAAAWPLLLVALLVLSWPPPGTEKIFSEVTPKCEDCQSLVKPDIVFFGESLPARFFSCMQSDFLKVDLLLVMGTSLQVQPFASLIS
KAPLSTPRLLINKEKAGQSDPFLGMIMGLGGGMDFDSKKAYRDVAWLGECDQGCLALAELLGWKKELEDLVRREHASIDAQSGAGVPNPS

>In-frame_PVR_ENST00000403059_chr19_45147475_+_SIRT2_ENST00000358931_chr19_39372131_-_88aa

>In-frame_PVR_ENST00000406449_chr19_45147475_+_SIRT2_ENST00000249396_chr19_39372131_-_206aa
MARAMAAAWPLLLVALLVLSWPPPGTEKIFSEVTPKCEDCQSLVKPDIVFFGESLPARFFSCMQSDFLKVDLLLVMGTSLQVQPFASLIS
KAPLSTPRLLINKEKAGQSDPFLGMIMGLGGGMDFDSKKAYRDVAWLGECDQGCLALAELLGWKKELEDLVRREHASIDAQSGAGVPNPS

>In-frame_PVR_ENST00000406449_chr19_45147475_+_SIRT2_ENST00000392081_chr19_39372131_-_206aa
MARAMAAAWPLLLVALLVLSWPPPGTEKIFSEVTPKCEDCQSLVKPDIVFFGESLPARFFSCMQSDFLKVDLLLVMGTSLQVQPFASLIS
KAPLSTPRLLINKEKAGQSDPFLGMIMGLGGGMDFDSKKAYRDVAWLGECDQGCLALAELLGWKKELEDLVRREHASIDAQSGAGVPNPS

>In-frame_PVR_ENST00000406449_chr19_45147475_+_SIRT2_ENST00000358931_chr19_39372131_-_88aa


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_PVR_ENST00000425690_chr19_45147475_+_SIRT2_ENST00000249396_chr19_39372131_-_618nt
ATGGCCCGAGCCATGGCCGCCGCGTGGCCGCTGCTGCTGGTGGCGCTACTGGTGCTGTCCTGGCCACCCCCAGGAACCGAGAAGATCTTC
TCTGAGGTGACGCCCAAGTGTGAAGACTGTCAGAGCCTGGTGAAGCCTGATATCGTCTTTTTTGGTGAGAGCCTCCCAGCGCGTTTCTTC
TCCTGTATGCAGTCAGACTTCCTGAAGGTGGACCTCCTCCTGGTCATGGGTACCTCCTTGCAGGTGCAGCCCTTTGCCTCCCTCATCAGC
AAGGCACCCCTCTCCACCCCTCGCCTGCTCATCAACAAGGAGAAAGCTGGCCAGTCGGACCCTTTCCTGGGGATGATTATGGGCCTCGGA
GGAGGCATGGACTTTGACTCCAAGAAGGCCTACAGGGACGTGGCCTGGCTGGGTGAATGCGACCAGGGCTGCCTGGCCCTTGCTGAGCTC
CTTGGATGGAAGAAGGAGCTGGAGGACCTTGTCCGGAGGGAGCACGCCAGCATAGATGCCCAGTCGGGGGCGGGGGTCCCCAACCCCAGC

>In-frame_PVR_ENST00000425690_chr19_45147475_+_SIRT2_ENST00000392081_chr19_39372131_-_618nt
ATGGCCCGAGCCATGGCCGCCGCGTGGCCGCTGCTGCTGGTGGCGCTACTGGTGCTGTCCTGGCCACCCCCAGGAACCGAGAAGATCTTC
TCTGAGGTGACGCCCAAGTGTGAAGACTGTCAGAGCCTGGTGAAGCCTGATATCGTCTTTTTTGGTGAGAGCCTCCCAGCGCGTTTCTTC
TCCTGTATGCAGTCAGACTTCCTGAAGGTGGACCTCCTCCTGGTCATGGGTACCTCCTTGCAGGTGCAGCCCTTTGCCTCCCTCATCAGC
AAGGCACCCCTCTCCACCCCTCGCCTGCTCATCAACAAGGAGAAAGCTGGCCAGTCGGACCCTTTCCTGGGGATGATTATGGGCCTCGGA
GGAGGCATGGACTTTGACTCCAAGAAGGCCTACAGGGACGTGGCCTGGCTGGGTGAATGCGACCAGGGCTGCCTGGCCCTTGCTGAGCTC
CTTGGATGGAAGAAGGAGCTGGAGGACCTTGTCCGGAGGGAGCACGCCAGCATAGATGCCCAGTCGGGGGCGGGGGTCCCCAACCCCAGC

>In-frame_PVR_ENST00000425690_chr19_45147475_+_SIRT2_ENST00000358931_chr19_39372131_-_264nt
ATGGCCCGAGCCATGGCCGCCGCGTGGCCGCTGCTGCTGGTGGCGCTACTGGTGCTGTCCTGGCCACCCCCAGGAACCGAGAAGATCTTC
TCTGAGGTGACGCCCAAGTGTGAAGACTGTCAGAGCCTGGTGAAGCCTGATATCGTCTTTTTTGGTGAGAGCCTCCCAGCGCGTTTCTTC

>In-frame_PVR_ENST00000344956_chr19_45147475_+_SIRT2_ENST00000249396_chr19_39372131_-_618nt
ATGGCCCGAGCCATGGCCGCCGCGTGGCCGCTGCTGCTGGTGGCGCTACTGGTGCTGTCCTGGCCACCCCCAGGAACCGAGAAGATCTTC
TCTGAGGTGACGCCCAAGTGTGAAGACTGTCAGAGCCTGGTGAAGCCTGATATCGTCTTTTTTGGTGAGAGCCTCCCAGCGCGTTTCTTC
TCCTGTATGCAGTCAGACTTCCTGAAGGTGGACCTCCTCCTGGTCATGGGTACCTCCTTGCAGGTGCAGCCCTTTGCCTCCCTCATCAGC
AAGGCACCCCTCTCCACCCCTCGCCTGCTCATCAACAAGGAGAAAGCTGGCCAGTCGGACCCTTTCCTGGGGATGATTATGGGCCTCGGA
GGAGGCATGGACTTTGACTCCAAGAAGGCCTACAGGGACGTGGCCTGGCTGGGTGAATGCGACCAGGGCTGCCTGGCCCTTGCTGAGCTC
CTTGGATGGAAGAAGGAGCTGGAGGACCTTGTCCGGAGGGAGCACGCCAGCATAGATGCCCAGTCGGGGGCGGGGGTCCCCAACCCCAGC

>In-frame_PVR_ENST00000344956_chr19_45147475_+_SIRT2_ENST00000392081_chr19_39372131_-_618nt
ATGGCCCGAGCCATGGCCGCCGCGTGGCCGCTGCTGCTGGTGGCGCTACTGGTGCTGTCCTGGCCACCCCCAGGAACCGAGAAGATCTTC
TCTGAGGTGACGCCCAAGTGTGAAGACTGTCAGAGCCTGGTGAAGCCTGATATCGTCTTTTTTGGTGAGAGCCTCCCAGCGCGTTTCTTC
TCCTGTATGCAGTCAGACTTCCTGAAGGTGGACCTCCTCCTGGTCATGGGTACCTCCTTGCAGGTGCAGCCCTTTGCCTCCCTCATCAGC
AAGGCACCCCTCTCCACCCCTCGCCTGCTCATCAACAAGGAGAAAGCTGGCCAGTCGGACCCTTTCCTGGGGATGATTATGGGCCTCGGA
GGAGGCATGGACTTTGACTCCAAGAAGGCCTACAGGGACGTGGCCTGGCTGGGTGAATGCGACCAGGGCTGCCTGGCCCTTGCTGAGCTC
CTTGGATGGAAGAAGGAGCTGGAGGACCTTGTCCGGAGGGAGCACGCCAGCATAGATGCCCAGTCGGGGGCGGGGGTCCCCAACCCCAGC

>In-frame_PVR_ENST00000344956_chr19_45147475_+_SIRT2_ENST00000358931_chr19_39372131_-_264nt
ATGGCCCGAGCCATGGCCGCCGCGTGGCCGCTGCTGCTGGTGGCGCTACTGGTGCTGTCCTGGCCACCCCCAGGAACCGAGAAGATCTTC
TCTGAGGTGACGCCCAAGTGTGAAGACTGTCAGAGCCTGGTGAAGCCTGATATCGTCTTTTTTGGTGAGAGCCTCCCAGCGCGTTTCTTC

>In-frame_PVR_ENST00000403059_chr19_45147475_+_SIRT2_ENST00000249396_chr19_39372131_-_618nt
ATGGCCCGAGCCATGGCCGCCGCGTGGCCGCTGCTGCTGGTGGCGCTACTGGTGCTGTCCTGGCCACCCCCAGGAACCGAGAAGATCTTC
TCTGAGGTGACGCCCAAGTGTGAAGACTGTCAGAGCCTGGTGAAGCCTGATATCGTCTTTTTTGGTGAGAGCCTCCCAGCGCGTTTCTTC
TCCTGTATGCAGTCAGACTTCCTGAAGGTGGACCTCCTCCTGGTCATGGGTACCTCCTTGCAGGTGCAGCCCTTTGCCTCCCTCATCAGC
AAGGCACCCCTCTCCACCCCTCGCCTGCTCATCAACAAGGAGAAAGCTGGCCAGTCGGACCCTTTCCTGGGGATGATTATGGGCCTCGGA
GGAGGCATGGACTTTGACTCCAAGAAGGCCTACAGGGACGTGGCCTGGCTGGGTGAATGCGACCAGGGCTGCCTGGCCCTTGCTGAGCTC
CTTGGATGGAAGAAGGAGCTGGAGGACCTTGTCCGGAGGGAGCACGCCAGCATAGATGCCCAGTCGGGGGCGGGGGTCCCCAACCCCAGC

>In-frame_PVR_ENST00000403059_chr19_45147475_+_SIRT2_ENST00000392081_chr19_39372131_-_618nt
ATGGCCCGAGCCATGGCCGCCGCGTGGCCGCTGCTGCTGGTGGCGCTACTGGTGCTGTCCTGGCCACCCCCAGGAACCGAGAAGATCTTC
TCTGAGGTGACGCCCAAGTGTGAAGACTGTCAGAGCCTGGTGAAGCCTGATATCGTCTTTTTTGGTGAGAGCCTCCCAGCGCGTTTCTTC
TCCTGTATGCAGTCAGACTTCCTGAAGGTGGACCTCCTCCTGGTCATGGGTACCTCCTTGCAGGTGCAGCCCTTTGCCTCCCTCATCAGC
AAGGCACCCCTCTCCACCCCTCGCCTGCTCATCAACAAGGAGAAAGCTGGCCAGTCGGACCCTTTCCTGGGGATGATTATGGGCCTCGGA
GGAGGCATGGACTTTGACTCCAAGAAGGCCTACAGGGACGTGGCCTGGCTGGGTGAATGCGACCAGGGCTGCCTGGCCCTTGCTGAGCTC
CTTGGATGGAAGAAGGAGCTGGAGGACCTTGTCCGGAGGGAGCACGCCAGCATAGATGCCCAGTCGGGGGCGGGGGTCCCCAACCCCAGC

>In-frame_PVR_ENST00000403059_chr19_45147475_+_SIRT2_ENST00000358931_chr19_39372131_-_264nt
ATGGCCCGAGCCATGGCCGCCGCGTGGCCGCTGCTGCTGGTGGCGCTACTGGTGCTGTCCTGGCCACCCCCAGGAACCGAGAAGATCTTC
TCTGAGGTGACGCCCAAGTGTGAAGACTGTCAGAGCCTGGTGAAGCCTGATATCGTCTTTTTTGGTGAGAGCCTCCCAGCGCGTTTCTTC

>In-frame_PVR_ENST00000406449_chr19_45147475_+_SIRT2_ENST00000249396_chr19_39372131_-_618nt
ATGGCCCGAGCCATGGCCGCCGCGTGGCCGCTGCTGCTGGTGGCGCTACTGGTGCTGTCCTGGCCACCCCCAGGAACCGAGAAGATCTTC
TCTGAGGTGACGCCCAAGTGTGAAGACTGTCAGAGCCTGGTGAAGCCTGATATCGTCTTTTTTGGTGAGAGCCTCCCAGCGCGTTTCTTC
TCCTGTATGCAGTCAGACTTCCTGAAGGTGGACCTCCTCCTGGTCATGGGTACCTCCTTGCAGGTGCAGCCCTTTGCCTCCCTCATCAGC
AAGGCACCCCTCTCCACCCCTCGCCTGCTCATCAACAAGGAGAAAGCTGGCCAGTCGGACCCTTTCCTGGGGATGATTATGGGCCTCGGA
GGAGGCATGGACTTTGACTCCAAGAAGGCCTACAGGGACGTGGCCTGGCTGGGTGAATGCGACCAGGGCTGCCTGGCCCTTGCTGAGCTC
CTTGGATGGAAGAAGGAGCTGGAGGACCTTGTCCGGAGGGAGCACGCCAGCATAGATGCCCAGTCGGGGGCGGGGGTCCCCAACCCCAGC

>In-frame_PVR_ENST00000406449_chr19_45147475_+_SIRT2_ENST00000392081_chr19_39372131_-_618nt
ATGGCCCGAGCCATGGCCGCCGCGTGGCCGCTGCTGCTGGTGGCGCTACTGGTGCTGTCCTGGCCACCCCCAGGAACCGAGAAGATCTTC
TCTGAGGTGACGCCCAAGTGTGAAGACTGTCAGAGCCTGGTGAAGCCTGATATCGTCTTTTTTGGTGAGAGCCTCCCAGCGCGTTTCTTC
TCCTGTATGCAGTCAGACTTCCTGAAGGTGGACCTCCTCCTGGTCATGGGTACCTCCTTGCAGGTGCAGCCCTTTGCCTCCCTCATCAGC
AAGGCACCCCTCTCCACCCCTCGCCTGCTCATCAACAAGGAGAAAGCTGGCCAGTCGGACCCTTTCCTGGGGATGATTATGGGCCTCGGA
GGAGGCATGGACTTTGACTCCAAGAAGGCCTACAGGGACGTGGCCTGGCTGGGTGAATGCGACCAGGGCTGCCTGGCCCTTGCTGAGCTC
CTTGGATGGAAGAAGGAGCTGGAGGACCTTGTCCGGAGGGAGCACGCCAGCATAGATGCCCAGTCGGGGGCGGGGGTCCCCAACCCCAGC

>In-frame_PVR_ENST00000406449_chr19_45147475_+_SIRT2_ENST00000358931_chr19_39372131_-_264nt
ATGGCCCGAGCCATGGCCGCCGCGTGGCCGCTGCTGCTGGTGGCGCTACTGGTGCTGTCCTGGCCACCCCCAGGAACCGAGAAGATCTTC
TCTGAGGTGACGCCCAAGTGTGAAGACTGTCAGAGCCTGGTGAAGCCTGATATCGTCTTTTTTGGTGAGAGCCTCCCAGCGCGTTTCTTC


* Fusion transcript sequences (Full-length transcript).
>In-frame_PVR_ENST00000425690_chr19_45147475_+_SIRT2_ENST00000249396_chr19_39372131_-_1515nt
AGCGGGACTGAGCGCCGGGAGAGACCTGCGCAGGCGCAGGCGCGCGGGAAGGGCCAGCCTGGGTGGCCCACCCCGCGCCTGGCGGGACTG
GCCGCCAACTCCCCTCCGCTCCAGTCACTTGTCTGGAGCTTGAAGAAGTGGGTATTCCCCTTCCCACCCCAGGCACTGGAGGAGCGGCCC
CCCGGGGATTCCAGGACCTGAGCTCCGGGAGCTGGACTCGCAGCGACCGCGGCAGAGCGAGCGGGCGCCGGGAAGCGAGGAGACGCCCGC
GGGAGGCCCAGCTGCTCGGAGCAACTGGCATGGCCCGAGCCATGGCCGCCGCGTGGCCGCTGCTGCTGGTGGCGCTACTGGTGCTGTCCT
GGCCACCCCCAGGAACCGAGAAGATCTTCTCTGAGGTGACGCCCAAGTGTGAAGACTGTCAGAGCCTGGTGAAGCCTGATATCGTCTTTT
TTGGTGAGAGCCTCCCAGCGCGTTTCTTCTCCTGTATGCAGTCAGACTTCCTGAAGGTGGACCTCCTCCTGGTCATGGGTACCTCCTTGC
AGGTGCAGCCCTTTGCCTCCCTCATCAGCAAGGCACCCCTCTCCACCCCTCGCCTGCTCATCAACAAGGAGAAAGCTGGCCAGTCGGACC
CTTTCCTGGGGATGATTATGGGCCTCGGAGGAGGCATGGACTTTGACTCCAAGAAGGCCTACAGGGACGTGGCCTGGCTGGGTGAATGCG
ACCAGGGCTGCCTGGCCCTTGCTGAGCTCCTTGGATGGAAGAAGGAGCTGGAGGACCTTGTCCGGAGGGAGCACGCCAGCATAGATGCCC
AGTCGGGGGCGGGGGTCCCCAACCCCAGCACTTCAGCTTCCCCCAAGAAGTCCCCGCCACCTGCCAAGGACGAGGCCAGGACAACAGAGA
GGGAGAAACCCCAGTGACAGCTGCATCTCCCAGGCGGGATGCCGAGCTCCTCAGGGACAGCTGAGCCCCAACCGGGCCTGGCCCCCTCTT
AACCAGCAGTTCTTGTCTGGGGAGCTCAGAACATCCCCCAATCTCTTACAGCTCCCTCCCCAAAACTGGGGTCCCAGCAACCCTGGCCCC
CAACCCCAGCAAATCTCTAACACCTCCTAGAGGCCAAGGCTTAAACAGGCATCTCTACCAGCCCCACTGTCTCTAACCACTCCTGGGCTA
AGGAGTAACCTCCCTCATCTCTAACTGCCCCCACGGGGCCAGGGCTACCCCAGAACTTTTAACTCTTCCAGGACAGGGAGCTTCGGGCCC
CCACTCTGTCTCCTGCCCCCGGGGGCCTGTGGCTAAGTAAACCATACCTAACCTACCCCAGTGTGGGTGTGGGCCTCTGAATATAACCCA
CACCCAGCGTAGGGGGAGTCTGAGCCGGGAGGGCTCCCGAGTCTCTGCCTTCAGCTCCCAAAGTGGGTGGTGGGCCCCCTTCACGTGGGA

>In-frame_PVR_ENST00000425690_chr19_45147475_+_SIRT2_ENST00000392081_chr19_39372131_-_1515nt
AGCGGGACTGAGCGCCGGGAGAGACCTGCGCAGGCGCAGGCGCGCGGGAAGGGCCAGCCTGGGTGGCCCACCCCGCGCCTGGCGGGACTG
GCCGCCAACTCCCCTCCGCTCCAGTCACTTGTCTGGAGCTTGAAGAAGTGGGTATTCCCCTTCCCACCCCAGGCACTGGAGGAGCGGCCC
CCCGGGGATTCCAGGACCTGAGCTCCGGGAGCTGGACTCGCAGCGACCGCGGCAGAGCGAGCGGGCGCCGGGAAGCGAGGAGACGCCCGC
GGGAGGCCCAGCTGCTCGGAGCAACTGGCATGGCCCGAGCCATGGCCGCCGCGTGGCCGCTGCTGCTGGTGGCGCTACTGGTGCTGTCCT
GGCCACCCCCAGGAACCGAGAAGATCTTCTCTGAGGTGACGCCCAAGTGTGAAGACTGTCAGAGCCTGGTGAAGCCTGATATCGTCTTTT
TTGGTGAGAGCCTCCCAGCGCGTTTCTTCTCCTGTATGCAGTCAGACTTCCTGAAGGTGGACCTCCTCCTGGTCATGGGTACCTCCTTGC
AGGTGCAGCCCTTTGCCTCCCTCATCAGCAAGGCACCCCTCTCCACCCCTCGCCTGCTCATCAACAAGGAGAAAGCTGGCCAGTCGGACC
CTTTCCTGGGGATGATTATGGGCCTCGGAGGAGGCATGGACTTTGACTCCAAGAAGGCCTACAGGGACGTGGCCTGGCTGGGTGAATGCG
ACCAGGGCTGCCTGGCCCTTGCTGAGCTCCTTGGATGGAAGAAGGAGCTGGAGGACCTTGTCCGGAGGGAGCACGCCAGCATAGATGCCC
AGTCGGGGGCGGGGGTCCCCAACCCCAGCACTTCAGCTTCCCCCAAGAAGTCCCCGCCACCTGCCAAGGACGAGGCCAGGACAACAGAGA
GGGAGAAACCCCAGTGACAGCTGCATCTCCCAGGCGGGATGCCGAGCTCCTCAGGGACAGCTGAGCCCCAACCGGGCCTGGCCCCCTCTT
AACCAGCAGTTCTTGTCTGGGGAGCTCAGAACATCCCCCAATCTCTTACAGCTCCCTCCCCAAAACTGGGGTCCCAGCAACCCTGGCCCC
CAACCCCAGCAAATCTCTAACACCTCCTAGAGGCCAAGGCTTAAACAGGCATCTCTACCAGCCCCACTGTCTCTAACCACTCCTGGGCTA
AGGAGTAACCTCCCTCATCTCTAACTGCCCCCACGGGGCCAGGGCTACCCCAGAACTTTTAACTCTTCCAGGACAGGGAGCTTCGGGCCC
CCACTCTGTCTCCTGCCCCCGGGGGCCTGTGGCTAAGTAAACCATACCTAACCTACCCCAGTGTGGGTGTGGGCCTCTGAATATAACCCA
CACCCAGCGTAGGGGGAGTCTGAGCCGGGAGGGCTCCCGAGTCTCTGCCTTCAGCTCCCAAAGTGGGTGGTGGGCCCCCTTCACGTGGGA

>In-frame_PVR_ENST00000425690_chr19_45147475_+_SIRT2_ENST00000358931_chr19_39372131_-_1339nt
AGCGGGACTGAGCGCCGGGAGAGACCTGCGCAGGCGCAGGCGCGCGGGAAGGGCCAGCCTGGGTGGCCCACCCCGCGCCTGGCGGGACTG
GCCGCCAACTCCCCTCCGCTCCAGTCACTTGTCTGGAGCTTGAAGAAGTGGGTATTCCCCTTCCCACCCCAGGCACTGGAGGAGCGGCCC
CCCGGGGATTCCAGGACCTGAGCTCCGGGAGCTGGACTCGCAGCGACCGCGGCAGAGCGAGCGGGCGCCGGGAAGCGAGGAGACGCCCGC
GGGAGGCCCAGCTGCTCGGAGCAACTGGCATGGCCCGAGCCATGGCCGCCGCGTGGCCGCTGCTGCTGGTGGCGCTACTGGTGCTGTCCT
GGCCACCCCCAGGAACCGAGAAGATCTTCTCTGAGGTGACGCCCAAGTGTGAAGACTGTCAGAGCCTGGTGAAGCCTGATATCGTCTTTT
TTGGTGAGAGCCTCCCAGCGCGTTTCTTCTCCTGTATGCAGTCAGACTTCCTGAAGGTGGACCTCCTCCTGGTCATGGGTACCTCCTTGC
AGGGACGTGGCCTGGCTGGGTGAATGCGACCAGGGCTGCCTGGCCCTTGCTGAGCTCCTTGGATGGAAGAAGGAGCTGGAGGACCTTGTC
CGGAGGGAGCACGCCAGCATAGATGCCCAGTCGGGGGCGGGGGTCCCCAACCCCAGCACTTCAGCTTCCCCCAAGAAGTCCCCGCCACCT
GCCAAGGACGAGGCCAGGACAACAGAGAGGGAGAAACCCCAGTGACAGCTGCATCTCCCAGGCGGGATGCCGAGCTCCTCAGGGACAGCT
GAGCCCCAACCGGGCCTGGCCCCCTCTTAACCAGCAGTTCTTGTCTGGGGAGCTCAGAACATCCCCCAATCTCTTACAGCTCCCTCCCCA
AAACTGGGGTCCCAGCAACCCTGGCCCCCAACCCCAGCAAATCTCTAACACCTCCTAGAGGCCAAGGCTTAAACAGGCATCTCTACCAGC
CCCACTGTCTCTAACCACTCCTGGGCTAAGGAGTAACCTCCCTCATCTCTAACTGCCCCCACGGGGCCAGGGCTACCCCAGAACTTTTAA
CTCTTCCAGGACAGGGAGCTTCGGGCCCCCACTCTGTCTCCTGCCCCCGGGGGCCTGTGGCTAAGTAAACCATACCTAACCTACCCCAGT
GTGGGTGTGGGCCTCTGAATATAACCCACACCCAGCGTAGGGGGAGTCTGAGCCGGGAGGGCTCCCGAGTCTCTGCCTTCAGCTCCCAAA

>In-frame_PVR_ENST00000344956_chr19_45147475_+_SIRT2_ENST00000249396_chr19_39372131_-_1515nt
AGCGGGACTGAGCGCCGGGAGAGACCTGCGCAGGCGCAGGCGCGCGGGAAGGGCCAGCCTGGGTGGCCCACCCCGCGCCTGGCGGGACTG
GCCGCCAACTCCCCTCCGCTCCAGTCACTTGTCTGGAGCTTGAAGAAGTGGGTATTCCCCTTCCCACCCCAGGCACTGGAGGAGCGGCCC
CCCGGGGATTCCAGGACCTGAGCTCCGGGAGCTGGACTCGCAGCGACCGCGGCAGAGCGAGCGGGCGCCGGGAAGCGAGGAGACGCCCGC
GGGAGGCCCAGCTGCTCGGAGCAACTGGCATGGCCCGAGCCATGGCCGCCGCGTGGCCGCTGCTGCTGGTGGCGCTACTGGTGCTGTCCT
GGCCACCCCCAGGAACCGAGAAGATCTTCTCTGAGGTGACGCCCAAGTGTGAAGACTGTCAGAGCCTGGTGAAGCCTGATATCGTCTTTT
TTGGTGAGAGCCTCCCAGCGCGTTTCTTCTCCTGTATGCAGTCAGACTTCCTGAAGGTGGACCTCCTCCTGGTCATGGGTACCTCCTTGC
AGGTGCAGCCCTTTGCCTCCCTCATCAGCAAGGCACCCCTCTCCACCCCTCGCCTGCTCATCAACAAGGAGAAAGCTGGCCAGTCGGACC
CTTTCCTGGGGATGATTATGGGCCTCGGAGGAGGCATGGACTTTGACTCCAAGAAGGCCTACAGGGACGTGGCCTGGCTGGGTGAATGCG
ACCAGGGCTGCCTGGCCCTTGCTGAGCTCCTTGGATGGAAGAAGGAGCTGGAGGACCTTGTCCGGAGGGAGCACGCCAGCATAGATGCCC
AGTCGGGGGCGGGGGTCCCCAACCCCAGCACTTCAGCTTCCCCCAAGAAGTCCCCGCCACCTGCCAAGGACGAGGCCAGGACAACAGAGA
GGGAGAAACCCCAGTGACAGCTGCATCTCCCAGGCGGGATGCCGAGCTCCTCAGGGACAGCTGAGCCCCAACCGGGCCTGGCCCCCTCTT
AACCAGCAGTTCTTGTCTGGGGAGCTCAGAACATCCCCCAATCTCTTACAGCTCCCTCCCCAAAACTGGGGTCCCAGCAACCCTGGCCCC
CAACCCCAGCAAATCTCTAACACCTCCTAGAGGCCAAGGCTTAAACAGGCATCTCTACCAGCCCCACTGTCTCTAACCACTCCTGGGCTA
AGGAGTAACCTCCCTCATCTCTAACTGCCCCCACGGGGCCAGGGCTACCCCAGAACTTTTAACTCTTCCAGGACAGGGAGCTTCGGGCCC
CCACTCTGTCTCCTGCCCCCGGGGGCCTGTGGCTAAGTAAACCATACCTAACCTACCCCAGTGTGGGTGTGGGCCTCTGAATATAACCCA
CACCCAGCGTAGGGGGAGTCTGAGCCGGGAGGGCTCCCGAGTCTCTGCCTTCAGCTCCCAAAGTGGGTGGTGGGCCCCCTTCACGTGGGA

>In-frame_PVR_ENST00000344956_chr19_45147475_+_SIRT2_ENST00000392081_chr19_39372131_-_1515nt
AGCGGGACTGAGCGCCGGGAGAGACCTGCGCAGGCGCAGGCGCGCGGGAAGGGCCAGCCTGGGTGGCCCACCCCGCGCCTGGCGGGACTG
GCCGCCAACTCCCCTCCGCTCCAGTCACTTGTCTGGAGCTTGAAGAAGTGGGTATTCCCCTTCCCACCCCAGGCACTGGAGGAGCGGCCC
CCCGGGGATTCCAGGACCTGAGCTCCGGGAGCTGGACTCGCAGCGACCGCGGCAGAGCGAGCGGGCGCCGGGAAGCGAGGAGACGCCCGC
GGGAGGCCCAGCTGCTCGGAGCAACTGGCATGGCCCGAGCCATGGCCGCCGCGTGGCCGCTGCTGCTGGTGGCGCTACTGGTGCTGTCCT
GGCCACCCCCAGGAACCGAGAAGATCTTCTCTGAGGTGACGCCCAAGTGTGAAGACTGTCAGAGCCTGGTGAAGCCTGATATCGTCTTTT
TTGGTGAGAGCCTCCCAGCGCGTTTCTTCTCCTGTATGCAGTCAGACTTCCTGAAGGTGGACCTCCTCCTGGTCATGGGTACCTCCTTGC
AGGTGCAGCCCTTTGCCTCCCTCATCAGCAAGGCACCCCTCTCCACCCCTCGCCTGCTCATCAACAAGGAGAAAGCTGGCCAGTCGGACC
CTTTCCTGGGGATGATTATGGGCCTCGGAGGAGGCATGGACTTTGACTCCAAGAAGGCCTACAGGGACGTGGCCTGGCTGGGTGAATGCG
ACCAGGGCTGCCTGGCCCTTGCTGAGCTCCTTGGATGGAAGAAGGAGCTGGAGGACCTTGTCCGGAGGGAGCACGCCAGCATAGATGCCC
AGTCGGGGGCGGGGGTCCCCAACCCCAGCACTTCAGCTTCCCCCAAGAAGTCCCCGCCACCTGCCAAGGACGAGGCCAGGACAACAGAGA
GGGAGAAACCCCAGTGACAGCTGCATCTCCCAGGCGGGATGCCGAGCTCCTCAGGGACAGCTGAGCCCCAACCGGGCCTGGCCCCCTCTT
AACCAGCAGTTCTTGTCTGGGGAGCTCAGAACATCCCCCAATCTCTTACAGCTCCCTCCCCAAAACTGGGGTCCCAGCAACCCTGGCCCC
CAACCCCAGCAAATCTCTAACACCTCCTAGAGGCCAAGGCTTAAACAGGCATCTCTACCAGCCCCACTGTCTCTAACCACTCCTGGGCTA
AGGAGTAACCTCCCTCATCTCTAACTGCCCCCACGGGGCCAGGGCTACCCCAGAACTTTTAACTCTTCCAGGACAGGGAGCTTCGGGCCC
CCACTCTGTCTCCTGCCCCCGGGGGCCTGTGGCTAAGTAAACCATACCTAACCTACCCCAGTGTGGGTGTGGGCCTCTGAATATAACCCA
CACCCAGCGTAGGGGGAGTCTGAGCCGGGAGGGCTCCCGAGTCTCTGCCTTCAGCTCCCAAAGTGGGTGGTGGGCCCCCTTCACGTGGGA

>In-frame_PVR_ENST00000344956_chr19_45147475_+_SIRT2_ENST00000358931_chr19_39372131_-_1339nt
AGCGGGACTGAGCGCCGGGAGAGACCTGCGCAGGCGCAGGCGCGCGGGAAGGGCCAGCCTGGGTGGCCCACCCCGCGCCTGGCGGGACTG
GCCGCCAACTCCCCTCCGCTCCAGTCACTTGTCTGGAGCTTGAAGAAGTGGGTATTCCCCTTCCCACCCCAGGCACTGGAGGAGCGGCCC
CCCGGGGATTCCAGGACCTGAGCTCCGGGAGCTGGACTCGCAGCGACCGCGGCAGAGCGAGCGGGCGCCGGGAAGCGAGGAGACGCCCGC
GGGAGGCCCAGCTGCTCGGAGCAACTGGCATGGCCCGAGCCATGGCCGCCGCGTGGCCGCTGCTGCTGGTGGCGCTACTGGTGCTGTCCT
GGCCACCCCCAGGAACCGAGAAGATCTTCTCTGAGGTGACGCCCAAGTGTGAAGACTGTCAGAGCCTGGTGAAGCCTGATATCGTCTTTT
TTGGTGAGAGCCTCCCAGCGCGTTTCTTCTCCTGTATGCAGTCAGACTTCCTGAAGGTGGACCTCCTCCTGGTCATGGGTACCTCCTTGC
AGGGACGTGGCCTGGCTGGGTGAATGCGACCAGGGCTGCCTGGCCCTTGCTGAGCTCCTTGGATGGAAGAAGGAGCTGGAGGACCTTGTC
CGGAGGGAGCACGCCAGCATAGATGCCCAGTCGGGGGCGGGGGTCCCCAACCCCAGCACTTCAGCTTCCCCCAAGAAGTCCCCGCCACCT
GCCAAGGACGAGGCCAGGACAACAGAGAGGGAGAAACCCCAGTGACAGCTGCATCTCCCAGGCGGGATGCCGAGCTCCTCAGGGACAGCT
GAGCCCCAACCGGGCCTGGCCCCCTCTTAACCAGCAGTTCTTGTCTGGGGAGCTCAGAACATCCCCCAATCTCTTACAGCTCCCTCCCCA
AAACTGGGGTCCCAGCAACCCTGGCCCCCAACCCCAGCAAATCTCTAACACCTCCTAGAGGCCAAGGCTTAAACAGGCATCTCTACCAGC
CCCACTGTCTCTAACCACTCCTGGGCTAAGGAGTAACCTCCCTCATCTCTAACTGCCCCCACGGGGCCAGGGCTACCCCAGAACTTTTAA
CTCTTCCAGGACAGGGAGCTTCGGGCCCCCACTCTGTCTCCTGCCCCCGGGGGCCTGTGGCTAAGTAAACCATACCTAACCTACCCCAGT
GTGGGTGTGGGCCTCTGAATATAACCCACACCCAGCGTAGGGGGAGTCTGAGCCGGGAGGGCTCCCGAGTCTCTGCCTTCAGCTCCCAAA

>In-frame_PVR_ENST00000403059_chr19_45147475_+_SIRT2_ENST00000249396_chr19_39372131_-_1403nt
AGTCACTTGTCTGGAGCTTGAAGAAGTGGGTATTCCCCTTCCCACCCCAGGCACTGGAGGAGCGGCCCCCCGGGGATTCCAGGACCTGAG
CTCCGGGAGCTGGACTCGCAGCGACCGCGGCAGAGCGAGCGGGCGCCGGGAAGCGAGGAGACGCCCGCGGGAGGCCCAGCTGCTCGGAGC
AACTGGCATGGCCCGAGCCATGGCCGCCGCGTGGCCGCTGCTGCTGGTGGCGCTACTGGTGCTGTCCTGGCCACCCCCAGGAACCGAGAA
GATCTTCTCTGAGGTGACGCCCAAGTGTGAAGACTGTCAGAGCCTGGTGAAGCCTGATATCGTCTTTTTTGGTGAGAGCCTCCCAGCGCG
TTTCTTCTCCTGTATGCAGTCAGACTTCCTGAAGGTGGACCTCCTCCTGGTCATGGGTACCTCCTTGCAGGTGCAGCCCTTTGCCTCCCT
CATCAGCAAGGCACCCCTCTCCACCCCTCGCCTGCTCATCAACAAGGAGAAAGCTGGCCAGTCGGACCCTTTCCTGGGGATGATTATGGG
CCTCGGAGGAGGCATGGACTTTGACTCCAAGAAGGCCTACAGGGACGTGGCCTGGCTGGGTGAATGCGACCAGGGCTGCCTGGCCCTTGC
TGAGCTCCTTGGATGGAAGAAGGAGCTGGAGGACCTTGTCCGGAGGGAGCACGCCAGCATAGATGCCCAGTCGGGGGCGGGGGTCCCCAA
CCCCAGCACTTCAGCTTCCCCCAAGAAGTCCCCGCCACCTGCCAAGGACGAGGCCAGGACAACAGAGAGGGAGAAACCCCAGTGACAGCT
GCATCTCCCAGGCGGGATGCCGAGCTCCTCAGGGACAGCTGAGCCCCAACCGGGCCTGGCCCCCTCTTAACCAGCAGTTCTTGTCTGGGG
AGCTCAGAACATCCCCCAATCTCTTACAGCTCCCTCCCCAAAACTGGGGTCCCAGCAACCCTGGCCCCCAACCCCAGCAAATCTCTAACA
CCTCCTAGAGGCCAAGGCTTAAACAGGCATCTCTACCAGCCCCACTGTCTCTAACCACTCCTGGGCTAAGGAGTAACCTCCCTCATCTCT
AACTGCCCCCACGGGGCCAGGGCTACCCCAGAACTTTTAACTCTTCCAGGACAGGGAGCTTCGGGCCCCCACTCTGTCTCCTGCCCCCGG
GGGCCTGTGGCTAAGTAAACCATACCTAACCTACCCCAGTGTGGGTGTGGGCCTCTGAATATAACCCACACCCAGCGTAGGGGGAGTCTG
AGCCGGGAGGGCTCCCGAGTCTCTGCCTTCAGCTCCCAAAGTGGGTGGTGGGCCCCCTTCACGTGGGACCCACTTCCCATGCTGGATGGG

>In-frame_PVR_ENST00000403059_chr19_45147475_+_SIRT2_ENST00000392081_chr19_39372131_-_1403nt
AGTCACTTGTCTGGAGCTTGAAGAAGTGGGTATTCCCCTTCCCACCCCAGGCACTGGAGGAGCGGCCCCCCGGGGATTCCAGGACCTGAG
CTCCGGGAGCTGGACTCGCAGCGACCGCGGCAGAGCGAGCGGGCGCCGGGAAGCGAGGAGACGCCCGCGGGAGGCCCAGCTGCTCGGAGC
AACTGGCATGGCCCGAGCCATGGCCGCCGCGTGGCCGCTGCTGCTGGTGGCGCTACTGGTGCTGTCCTGGCCACCCCCAGGAACCGAGAA
GATCTTCTCTGAGGTGACGCCCAAGTGTGAAGACTGTCAGAGCCTGGTGAAGCCTGATATCGTCTTTTTTGGTGAGAGCCTCCCAGCGCG
TTTCTTCTCCTGTATGCAGTCAGACTTCCTGAAGGTGGACCTCCTCCTGGTCATGGGTACCTCCTTGCAGGTGCAGCCCTTTGCCTCCCT
CATCAGCAAGGCACCCCTCTCCACCCCTCGCCTGCTCATCAACAAGGAGAAAGCTGGCCAGTCGGACCCTTTCCTGGGGATGATTATGGG
CCTCGGAGGAGGCATGGACTTTGACTCCAAGAAGGCCTACAGGGACGTGGCCTGGCTGGGTGAATGCGACCAGGGCTGCCTGGCCCTTGC
TGAGCTCCTTGGATGGAAGAAGGAGCTGGAGGACCTTGTCCGGAGGGAGCACGCCAGCATAGATGCCCAGTCGGGGGCGGGGGTCCCCAA
CCCCAGCACTTCAGCTTCCCCCAAGAAGTCCCCGCCACCTGCCAAGGACGAGGCCAGGACAACAGAGAGGGAGAAACCCCAGTGACAGCT
GCATCTCCCAGGCGGGATGCCGAGCTCCTCAGGGACAGCTGAGCCCCAACCGGGCCTGGCCCCCTCTTAACCAGCAGTTCTTGTCTGGGG
AGCTCAGAACATCCCCCAATCTCTTACAGCTCCCTCCCCAAAACTGGGGTCCCAGCAACCCTGGCCCCCAACCCCAGCAAATCTCTAACA
CCTCCTAGAGGCCAAGGCTTAAACAGGCATCTCTACCAGCCCCACTGTCTCTAACCACTCCTGGGCTAAGGAGTAACCTCCCTCATCTCT
AACTGCCCCCACGGGGCCAGGGCTACCCCAGAACTTTTAACTCTTCCAGGACAGGGAGCTTCGGGCCCCCACTCTGTCTCCTGCCCCCGG
GGGCCTGTGGCTAAGTAAACCATACCTAACCTACCCCAGTGTGGGTGTGGGCCTCTGAATATAACCCACACCCAGCGTAGGGGGAGTCTG
AGCCGGGAGGGCTCCCGAGTCTCTGCCTTCAGCTCCCAAAGTGGGTGGTGGGCCCCCTTCACGTGGGACCCACTTCCCATGCTGGATGGG

>In-frame_PVR_ENST00000403059_chr19_45147475_+_SIRT2_ENST00000358931_chr19_39372131_-_1227nt
AGTCACTTGTCTGGAGCTTGAAGAAGTGGGTATTCCCCTTCCCACCCCAGGCACTGGAGGAGCGGCCCCCCGGGGATTCCAGGACCTGAG
CTCCGGGAGCTGGACTCGCAGCGACCGCGGCAGAGCGAGCGGGCGCCGGGAAGCGAGGAGACGCCCGCGGGAGGCCCAGCTGCTCGGAGC
AACTGGCATGGCCCGAGCCATGGCCGCCGCGTGGCCGCTGCTGCTGGTGGCGCTACTGGTGCTGTCCTGGCCACCCCCAGGAACCGAGAA
GATCTTCTCTGAGGTGACGCCCAAGTGTGAAGACTGTCAGAGCCTGGTGAAGCCTGATATCGTCTTTTTTGGTGAGAGCCTCCCAGCGCG
TTTCTTCTCCTGTATGCAGTCAGACTTCCTGAAGGTGGACCTCCTCCTGGTCATGGGTACCTCCTTGCAGGGACGTGGCCTGGCTGGGTG
AATGCGACCAGGGCTGCCTGGCCCTTGCTGAGCTCCTTGGATGGAAGAAGGAGCTGGAGGACCTTGTCCGGAGGGAGCACGCCAGCATAG
ATGCCCAGTCGGGGGCGGGGGTCCCCAACCCCAGCACTTCAGCTTCCCCCAAGAAGTCCCCGCCACCTGCCAAGGACGAGGCCAGGACAA
CAGAGAGGGAGAAACCCCAGTGACAGCTGCATCTCCCAGGCGGGATGCCGAGCTCCTCAGGGACAGCTGAGCCCCAACCGGGCCTGGCCC
CCTCTTAACCAGCAGTTCTTGTCTGGGGAGCTCAGAACATCCCCCAATCTCTTACAGCTCCCTCCCCAAAACTGGGGTCCCAGCAACCCT
GGCCCCCAACCCCAGCAAATCTCTAACACCTCCTAGAGGCCAAGGCTTAAACAGGCATCTCTACCAGCCCCACTGTCTCTAACCACTCCT
GGGCTAAGGAGTAACCTCCCTCATCTCTAACTGCCCCCACGGGGCCAGGGCTACCCCAGAACTTTTAACTCTTCCAGGACAGGGAGCTTC
GGGCCCCCACTCTGTCTCCTGCCCCCGGGGGCCTGTGGCTAAGTAAACCATACCTAACCTACCCCAGTGTGGGTGTGGGCCTCTGAATAT
AACCCACACCCAGCGTAGGGGGAGTCTGAGCCGGGAGGGCTCCCGAGTCTCTGCCTTCAGCTCCCAAAGTGGGTGGTGGGCCCCCTTCAC

>In-frame_PVR_ENST00000406449_chr19_45147475_+_SIRT2_ENST00000249396_chr19_39372131_-_1216nt
ATGGCCCGAGCCATGGCCGCCGCGTGGCCGCTGCTGCTGGTGGCGCTACTGGTGCTGTCCTGGCCACCCCCAGGAACCGAGAAGATCTTC
TCTGAGGTGACGCCCAAGTGTGAAGACTGTCAGAGCCTGGTGAAGCCTGATATCGTCTTTTTTGGTGAGAGCCTCCCAGCGCGTTTCTTC
TCCTGTATGCAGTCAGACTTCCTGAAGGTGGACCTCCTCCTGGTCATGGGTACCTCCTTGCAGGTGCAGCCCTTTGCCTCCCTCATCAGC
AAGGCACCCCTCTCCACCCCTCGCCTGCTCATCAACAAGGAGAAAGCTGGCCAGTCGGACCCTTTCCTGGGGATGATTATGGGCCTCGGA
GGAGGCATGGACTTTGACTCCAAGAAGGCCTACAGGGACGTGGCCTGGCTGGGTGAATGCGACCAGGGCTGCCTGGCCCTTGCTGAGCTC
CTTGGATGGAAGAAGGAGCTGGAGGACCTTGTCCGGAGGGAGCACGCCAGCATAGATGCCCAGTCGGGGGCGGGGGTCCCCAACCCCAGC
ACTTCAGCTTCCCCCAAGAAGTCCCCGCCACCTGCCAAGGACGAGGCCAGGACAACAGAGAGGGAGAAACCCCAGTGACAGCTGCATCTC
CCAGGCGGGATGCCGAGCTCCTCAGGGACAGCTGAGCCCCAACCGGGCCTGGCCCCCTCTTAACCAGCAGTTCTTGTCTGGGGAGCTCAG
AACATCCCCCAATCTCTTACAGCTCCCTCCCCAAAACTGGGGTCCCAGCAACCCTGGCCCCCAACCCCAGCAAATCTCTAACACCTCCTA
GAGGCCAAGGCTTAAACAGGCATCTCTACCAGCCCCACTGTCTCTAACCACTCCTGGGCTAAGGAGTAACCTCCCTCATCTCTAACTGCC
CCCACGGGGCCAGGGCTACCCCAGAACTTTTAACTCTTCCAGGACAGGGAGCTTCGGGCCCCCACTCTGTCTCCTGCCCCCGGGGGCCTG
TGGCTAAGTAAACCATACCTAACCTACCCCAGTGTGGGTGTGGGCCTCTGAATATAACCCACACCCAGCGTAGGGGGAGTCTGAGCCGGG
AGGGCTCCCGAGTCTCTGCCTTCAGCTCCCAAAGTGGGTGGTGGGCCCCCTTCACGTGGGACCCACTTCCCATGCTGGATGGGCAGAAGA

>In-frame_PVR_ENST00000406449_chr19_45147475_+_SIRT2_ENST00000392081_chr19_39372131_-_1216nt
ATGGCCCGAGCCATGGCCGCCGCGTGGCCGCTGCTGCTGGTGGCGCTACTGGTGCTGTCCTGGCCACCCCCAGGAACCGAGAAGATCTTC
TCTGAGGTGACGCCCAAGTGTGAAGACTGTCAGAGCCTGGTGAAGCCTGATATCGTCTTTTTTGGTGAGAGCCTCCCAGCGCGTTTCTTC
TCCTGTATGCAGTCAGACTTCCTGAAGGTGGACCTCCTCCTGGTCATGGGTACCTCCTTGCAGGTGCAGCCCTTTGCCTCCCTCATCAGC
AAGGCACCCCTCTCCACCCCTCGCCTGCTCATCAACAAGGAGAAAGCTGGCCAGTCGGACCCTTTCCTGGGGATGATTATGGGCCTCGGA
GGAGGCATGGACTTTGACTCCAAGAAGGCCTACAGGGACGTGGCCTGGCTGGGTGAATGCGACCAGGGCTGCCTGGCCCTTGCTGAGCTC
CTTGGATGGAAGAAGGAGCTGGAGGACCTTGTCCGGAGGGAGCACGCCAGCATAGATGCCCAGTCGGGGGCGGGGGTCCCCAACCCCAGC
ACTTCAGCTTCCCCCAAGAAGTCCCCGCCACCTGCCAAGGACGAGGCCAGGACAACAGAGAGGGAGAAACCCCAGTGACAGCTGCATCTC
CCAGGCGGGATGCCGAGCTCCTCAGGGACAGCTGAGCCCCAACCGGGCCTGGCCCCCTCTTAACCAGCAGTTCTTGTCTGGGGAGCTCAG
AACATCCCCCAATCTCTTACAGCTCCCTCCCCAAAACTGGGGTCCCAGCAACCCTGGCCCCCAACCCCAGCAAATCTCTAACACCTCCTA
GAGGCCAAGGCTTAAACAGGCATCTCTACCAGCCCCACTGTCTCTAACCACTCCTGGGCTAAGGAGTAACCTCCCTCATCTCTAACTGCC
CCCACGGGGCCAGGGCTACCCCAGAACTTTTAACTCTTCCAGGACAGGGAGCTTCGGGCCCCCACTCTGTCTCCTGCCCCCGGGGGCCTG
TGGCTAAGTAAACCATACCTAACCTACCCCAGTGTGGGTGTGGGCCTCTGAATATAACCCACACCCAGCGTAGGGGGAGTCTGAGCCGGG
AGGGCTCCCGAGTCTCTGCCTTCAGCTCCCAAAGTGGGTGGTGGGCCCCCTTCACGTGGGACCCACTTCCCATGCTGGATGGGCAGAAGA

>In-frame_PVR_ENST00000406449_chr19_45147475_+_SIRT2_ENST00000358931_chr19_39372131_-_1040nt
ATGGCCCGAGCCATGGCCGCCGCGTGGCCGCTGCTGCTGGTGGCGCTACTGGTGCTGTCCTGGCCACCCCCAGGAACCGAGAAGATCTTC
TCTGAGGTGACGCCCAAGTGTGAAGACTGTCAGAGCCTGGTGAAGCCTGATATCGTCTTTTTTGGTGAGAGCCTCCCAGCGCGTTTCTTC
TCCTGTATGCAGTCAGACTTCCTGAAGGTGGACCTCCTCCTGGTCATGGGTACCTCCTTGCAGGGACGTGGCCTGGCTGGGTGAATGCGA
CCAGGGCTGCCTGGCCCTTGCTGAGCTCCTTGGATGGAAGAAGGAGCTGGAGGACCTTGTCCGGAGGGAGCACGCCAGCATAGATGCCCA
GTCGGGGGCGGGGGTCCCCAACCCCAGCACTTCAGCTTCCCCCAAGAAGTCCCCGCCACCTGCCAAGGACGAGGCCAGGACAACAGAGAG
GGAGAAACCCCAGTGACAGCTGCATCTCCCAGGCGGGATGCCGAGCTCCTCAGGGACAGCTGAGCCCCAACCGGGCCTGGCCCCCTCTTA
ACCAGCAGTTCTTGTCTGGGGAGCTCAGAACATCCCCCAATCTCTTACAGCTCCCTCCCCAAAACTGGGGTCCCAGCAACCCTGGCCCCC
AACCCCAGCAAATCTCTAACACCTCCTAGAGGCCAAGGCTTAAACAGGCATCTCTACCAGCCCCACTGTCTCTAACCACTCCTGGGCTAA
GGAGTAACCTCCCTCATCTCTAACTGCCCCCACGGGGCCAGGGCTACCCCAGAACTTTTAACTCTTCCAGGACAGGGAGCTTCGGGCCCC
CACTCTGTCTCCTGCCCCCGGGGGCCTGTGGCTAAGTAAACCATACCTAACCTACCCCAGTGTGGGTGTGGGCCTCTGAATATAACCCAC
ACCCAGCGTAGGGGGAGTCTGAGCCGGGAGGGCTCCCGAGTCTCTGCCTTCAGCTCCCAAAGTGGGTGGTGGGCCCCCTTCACGTGGGAC


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FusionGenePPI for PVR_SIRT2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PVRCD226, PVRL3, DYNLT1, AP1M2, VTN, ELAVL1, ZC3HAV1, TIGIT, PLA2G3, WNK1, SLC30A2, KRTAP10-7, KRTAP10-9, KRTAP10-8, KRTAP10-3, NOTCH2NL, CD96, NLRX1, C4A, UBE2C, RYK, CDON, PI4K2A, RAB5B, LRBA, FBXL20, GNPAT, MMS22L, MTCH2, XPO6, QSOX1, ATR, FAM20B, GPD2, PPM1B, LANCL2, ALG5, USP30, ARV1, GNA13, CISD2, METAP2, XPO5, TNFSF9, HELLS, ALG11, ULBP3, STAT3, RFC3, EFNB1, FAM134A, TRIM25SIRT2PHB2, SPOP, GYS1, RTN4, KRT78, ELL, SARS, DNAJB6, DNAJB8, NUDT21, PAPOLA, HIST1H3A, EP300, ING1, RBP1, SIRT1, FOXO1, HDAC6, PCK1, RUNX3, FZR1, CDC20, XPO1, CBLB, CBL, ACLY, SNAI1, RAB3GAP2, GPAM, RAB3GAP1, SCFD2, FADS1, MTDH, DEGS1, ORC2, TRAPPC12, VAMP7, NUDT12, TUBA4A, RAD51, BTRC, AHI1, CEP89, FBF1, ODF2, RPGRIP1L, SCLT1, PPP1CB, TINF2, GCKR, SKP2, MDM2, PLA2G4A, CDK2, MOAP1, DMD, SLC22A23, GSTT1, GSTT2B, MANSC1, KIAA0930, ARHGDIA


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PVR_SIRT2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PVR_SIRT2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePVRC0032371Poliomyelitis1CTD_human
TgeneSIRT2C0525045Mood Disorders1PSYGENET
TgeneSIRT2C2939186Disturbance in mood1PSYGENET