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Fusion gene ID: 29665

FusionGeneSummary for PUM1_RAP1A

Fusion gene summary

Fusion gene information	Fusion gene name: PUM1_RAP1A
	Fusion gene ID: 29665
		Hgene	Tgene
	Gene symbol	PUM1	RAP1A
	Gene ID	9698	5906
	Gene name	pumilio RNA binding family member 1	RAP1A, member of RAS oncogene family
	Synonyms	HSPUM\|PUMH\|PUMH1\|PUML1\|SCA47	C21KG\|G-22K\|KREV-1\|KREV1\|RAP1\|SMGP21
	Cytomap	1p35.2	1p13.2
	Type of gene	protein-coding	protein-coding
	Description	pumilio homolog 1pumilio-1	ras-related protein Rap-1AGTP-binding protein smg p21ARas-related protein Krev-1
	Modification date	20180519	20180522
	UniProtAcc	Q14671	P62834
	Ensembl transtripts involved in fusion gene	ENST00000424085, ENST00000257075, ENST00000373747, ENST00000426105, ENST00000440538, ENST00000373741, ENST00000423018, ENST00000373742, ENST00000490546,	ENST00000356415, ENST00000436150, ENST00000369709, ENST00000545460, ENST00000494982,
Fusion gene scores	* DoF score	26 X 16 X 15=6240	5 X 6 X 3=90
	# samples	34	7
	** MAII score	log2(34/6240*10)=-4.19793937761191 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(7/90*10)=-0.362570079384708 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: PUM1 [Title/Abstract] AND RAP1A [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	PUM1	GO:0010608	posttranscriptional regulation of gene expression	25100735
Hgene	PUM1	GO:0043488	regulation of mRNA stability	26724866
Hgene	PUM1	GO:0051726	regulation of cell cycle	20818387
Hgene	PUM1	GO:0051983	regulation of chromosome segregation	26724866
Hgene	PUM1	GO:1900246	positive regulation of RIG-I signaling pathway	25340845
Hgene	PUM1	GO:2000637	positive regulation of gene silencing by miRNA	20818387\|22345517
Tgene	RAP1A	GO:0015031	protein transport	17916086
Tgene	RAP1A	GO:0071320	cellular response to cAMP	21840392

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	RV	CESC	TCGA-BI-A0VR-01A	PUM1	chr1	31501643	-	RAP1A	chr1	112170092	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000424085	ENST00000356415	PUM1	chr1	31501643	-	RAP1A	chr1	112170092	+
5CDS-5UTR	ENST00000424085	ENST00000436150	PUM1	chr1	31501643	-	RAP1A	chr1	112170092	+
5CDS-intron	ENST00000424085	ENST00000369709	PUM1	chr1	31501643	-	RAP1A	chr1	112170092	+
5CDS-intron	ENST00000424085	ENST00000545460	PUM1	chr1	31501643	-	RAP1A	chr1	112170092	+
5CDS-intron	ENST00000424085	ENST00000494982	PUM1	chr1	31501643	-	RAP1A	chr1	112170092	+
5CDS-intron	ENST00000257075	ENST00000356415	PUM1	chr1	31501643	-	RAP1A	chr1	112170092	+
5CDS-5UTR	ENST00000257075	ENST00000436150	PUM1	chr1	31501643	-	RAP1A	chr1	112170092	+
5CDS-intron	ENST00000257075	ENST00000369709	PUM1	chr1	31501643	-	RAP1A	chr1	112170092	+
5CDS-intron	ENST00000257075	ENST00000545460	PUM1	chr1	31501643	-	RAP1A	chr1	112170092	+
5CDS-intron	ENST00000257075	ENST00000494982	PUM1	chr1	31501643	-	RAP1A	chr1	112170092	+
5CDS-intron	ENST00000373747	ENST00000356415	PUM1	chr1	31501643	-	RAP1A	chr1	112170092	+
5CDS-5UTR	ENST00000373747	ENST00000436150	PUM1	chr1	31501643	-	RAP1A	chr1	112170092	+
5CDS-intron	ENST00000373747	ENST00000369709	PUM1	chr1	31501643	-	RAP1A	chr1	112170092	+
5CDS-intron	ENST00000373747	ENST00000545460	PUM1	chr1	31501643	-	RAP1A	chr1	112170092	+
5CDS-intron	ENST00000373747	ENST00000494982	PUM1	chr1	31501643	-	RAP1A	chr1	112170092	+
5CDS-intron	ENST00000426105	ENST00000356415	PUM1	chr1	31501643	-	RAP1A	chr1	112170092	+
5CDS-5UTR	ENST00000426105	ENST00000436150	PUM1	chr1	31501643	-	RAP1A	chr1	112170092	+
5CDS-intron	ENST00000426105	ENST00000369709	PUM1	chr1	31501643	-	RAP1A	chr1	112170092	+
5CDS-intron	ENST00000426105	ENST00000545460	PUM1	chr1	31501643	-	RAP1A	chr1	112170092	+
5CDS-intron	ENST00000426105	ENST00000494982	PUM1	chr1	31501643	-	RAP1A	chr1	112170092	+
5CDS-intron	ENST00000440538	ENST00000356415	PUM1	chr1	31501643	-	RAP1A	chr1	112170092	+
5CDS-5UTR	ENST00000440538	ENST00000436150	PUM1	chr1	31501643	-	RAP1A	chr1	112170092	+
5CDS-intron	ENST00000440538	ENST00000369709	PUM1	chr1	31501643	-	RAP1A	chr1	112170092	+
5CDS-intron	ENST00000440538	ENST00000545460	PUM1	chr1	31501643	-	RAP1A	chr1	112170092	+
5CDS-intron	ENST00000440538	ENST00000494982	PUM1	chr1	31501643	-	RAP1A	chr1	112170092	+
5CDS-intron	ENST00000373741	ENST00000356415	PUM1	chr1	31501643	-	RAP1A	chr1	112170092	+
5CDS-5UTR	ENST00000373741	ENST00000436150	PUM1	chr1	31501643	-	RAP1A	chr1	112170092	+
5CDS-intron	ENST00000373741	ENST00000369709	PUM1	chr1	31501643	-	RAP1A	chr1	112170092	+
5CDS-intron	ENST00000373741	ENST00000545460	PUM1	chr1	31501643	-	RAP1A	chr1	112170092	+
5CDS-intron	ENST00000373741	ENST00000494982	PUM1	chr1	31501643	-	RAP1A	chr1	112170092	+
5CDS-intron	ENST00000423018	ENST00000356415	PUM1	chr1	31501643	-	RAP1A	chr1	112170092	+
5CDS-5UTR	ENST00000423018	ENST00000436150	PUM1	chr1	31501643	-	RAP1A	chr1	112170092	+
5CDS-intron	ENST00000423018	ENST00000369709	PUM1	chr1	31501643	-	RAP1A	chr1	112170092	+
5CDS-intron	ENST00000423018	ENST00000545460	PUM1	chr1	31501643	-	RAP1A	chr1	112170092	+
5CDS-intron	ENST00000423018	ENST00000494982	PUM1	chr1	31501643	-	RAP1A	chr1	112170092	+
5CDS-intron	ENST00000373742	ENST00000356415	PUM1	chr1	31501643	-	RAP1A	chr1	112170092	+
5CDS-5UTR	ENST00000373742	ENST00000436150	PUM1	chr1	31501643	-	RAP1A	chr1	112170092	+
5CDS-intron	ENST00000373742	ENST00000369709	PUM1	chr1	31501643	-	RAP1A	chr1	112170092	+
5CDS-intron	ENST00000373742	ENST00000545460	PUM1	chr1	31501643	-	RAP1A	chr1	112170092	+
5CDS-intron	ENST00000373742	ENST00000494982	PUM1	chr1	31501643	-	RAP1A	chr1	112170092	+
intron-intron	ENST00000490546	ENST00000356415	PUM1	chr1	31501643	-	RAP1A	chr1	112170092	+
intron-5UTR	ENST00000490546	ENST00000436150	PUM1	chr1	31501643	-	RAP1A	chr1	112170092	+
intron-intron	ENST00000490546	ENST00000369709	PUM1	chr1	31501643	-	RAP1A	chr1	112170092	+
intron-intron	ENST00000490546	ENST00000545460	PUM1	chr1	31501643	-	RAP1A	chr1	112170092	+
intron-intron	ENST00000490546	ENST00000494982	PUM1	chr1	31501643	-	RAP1A	chr1	112170092	+

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FusionProtFeatures for PUM1_RAP1A

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
PUM1 Q14671	RAP1A P62834

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Fusion gene ID: 29665

FusionGeneSummary for PUM1_RAP1A

FusionProtFeatures for PUM1_RAP1A