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Fusion gene ID: 29611 |
FusionGeneSummary for PTPRZ1_DOCK4 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PTPRZ1_DOCK4 | Fusion gene ID: 29611 | Hgene | Tgene | Gene symbol | PTPRZ1 | DOCK4 | Gene ID | 5803 | 9732 |
| Gene name | protein tyrosine phosphatase, receptor type Z1 | dedicator of cytokinesis 4 | |
| Synonyms | HPTPZ|HPTPzeta|PTP-ZETA|PTP18|PTPRZ|PTPZ|R-PTP-zeta-2|RPTPB|RPTPbeta|phosphacan | - | |
| Cytomap | 7q31.32 | 7q31.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | receptor-type tyrosine-protein phosphatase zetaprotein tyrosine phosphatase, receptor-type, Z polypeptide 1protein tyrosine phosphatase, receptor-type, zeta polypeptide 1protein-tyrosine phosphatase receptor type Z polypeptide 2receptor-type tyrosine | dedicator of cytokinesis protein 4 | |
| Modification date | 20180519 | 20180525 | |
| UniProtAcc | P23471 | Q8N1I0 | |
| Ensembl transtripts involved in fusion gene | ENST00000393386, ENST00000449182, ENST00000483028, | ENST00000428084, ENST00000494651, ENST00000437633, ENST00000476846, | |
| Fusion gene scores | * DoF score | 12 X 12 X 7=1008 | 4 X 5 X 6=120 |
| # samples | 16 | 6 | |
| ** MAII score | log2(16/1008*10)=-2.65535182861255 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/120*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: PTPRZ1 [Title/Abstract] AND DOCK4 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SKCM | TCGA-EE-A20I-06A | PTPRZ1 | chr7 | 121624171 | + | DOCK4 | chr7 | 111644186 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000393386 | ENST00000428084 | PTPRZ1 | chr7 | 121624171 | + | DOCK4 | chr7 | 111644186 | - |
| 5CDS-intron | ENST00000393386 | ENST00000494651 | PTPRZ1 | chr7 | 121624171 | + | DOCK4 | chr7 | 111644186 | - |
| 5CDS-intron | ENST00000393386 | ENST00000437633 | PTPRZ1 | chr7 | 121624171 | + | DOCK4 | chr7 | 111644186 | - |
| 5CDS-5UTR | ENST00000393386 | ENST00000476846 | PTPRZ1 | chr7 | 121624171 | + | DOCK4 | chr7 | 111644186 | - |
| In-frame | ENST00000449182 | ENST00000428084 | PTPRZ1 | chr7 | 121624171 | + | DOCK4 | chr7 | 111644186 | - |
| 5CDS-intron | ENST00000449182 | ENST00000494651 | PTPRZ1 | chr7 | 121624171 | + | DOCK4 | chr7 | 111644186 | - |
| 5CDS-intron | ENST00000449182 | ENST00000437633 | PTPRZ1 | chr7 | 121624171 | + | DOCK4 | chr7 | 111644186 | - |
| 5CDS-5UTR | ENST00000449182 | ENST00000476846 | PTPRZ1 | chr7 | 121624171 | + | DOCK4 | chr7 | 111644186 | - |
| intron-3CDS | ENST00000483028 | ENST00000428084 | PTPRZ1 | chr7 | 121624171 | + | DOCK4 | chr7 | 111644186 | - |
| intron-intron | ENST00000483028 | ENST00000494651 | PTPRZ1 | chr7 | 121624171 | + | DOCK4 | chr7 | 111644186 | - |
| intron-intron | ENST00000483028 | ENST00000437633 | PTPRZ1 | chr7 | 121624171 | + | DOCK4 | chr7 | 111644186 | - |
| intron-5UTR | ENST00000483028 | ENST00000476846 | PTPRZ1 | chr7 | 121624171 | + | DOCK4 | chr7 | 111644186 | - |
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FusionProtFeatures for PTPRZ1_DOCK4 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PTPRZ1 | DOCK4 |