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Fusion gene ID: 29535

FusionGeneSummary for PTPRK_EYA4

Fusion gene summary

Fusion gene information	Fusion gene name: PTPRK_EYA4
	Fusion gene ID: 29535
		Hgene	Tgene
	Gene symbol	PTPRK	EYA4
	Gene ID	5796	2070
	Gene name	protein tyrosine phosphatase, receptor type K	EYA transcriptional coactivator and phosphatase 4
	Synonyms	R-PTP-kappa	CMD1J\|DFNA10
	Cytomap	6q22.33	6q23.2
	Type of gene	protein-coding	protein-coding
	Description	receptor-type tyrosine-protein phosphatase kappadJ480J14.2.1 (protein tyrosine phosphatase, receptor type, K (R-PTP-KAPPA, protein tyrosine phosphatase kappa , protein tyrosine phosphatase kappaprotein-tyrosine phosphatase kappaprotein-tyrosine phospha	eyes absent homolog 4dJ78N10.1 (eyes absent)eyes absent-like protein 4
	Modification date	20180519	20180523
	UniProtAcc	Q15262	O95677
	Ensembl transtripts involved in fusion gene	ENST00000368226, ENST00000368227, ENST00000532331, ENST00000368213, ENST00000368210, ENST00000368215, ENST00000368207, ENST00000524481, ENST00000525459,	ENST00000452339, ENST00000430974, ENST00000367895, ENST00000355167, ENST00000355286, ENST00000531901, ENST00000525849, ENST00000431403, ENST00000441015,
Fusion gene scores	* DoF score	26 X 12 X 13=4056	3 X 3 X 3=27
	# samples	34	3
	** MAII score	log2(34/4056*10)=-3.57645100086564 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: PTPRK [Title/Abstract] AND EYA4 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation	Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	PTPRK	GO:0006470	protein dephosphorylation	16263724
Hgene	PTPRK	GO:0007165	signal transduction	16849327
Hgene	PTPRK	GO:0007179	transforming growth factor beta receptor signaling pathway	15899872
Hgene	PTPRK	GO:0008285	negative regulation of cell proliferation	15899872\|18276111
Hgene	PTPRK	GO:0010839	negative regulation of keratinocyte proliferation	16263724
Hgene	PTPRK	GO:0030336	negative regulation of cell migration	18276111
Hgene	PTPRK	GO:0034394	protein localization to cell surface	18276111
Hgene	PTPRK	GO:0034614	cellular response to reactive oxygen species	16849327
Hgene	PTPRK	GO:0034644	cellular response to UV	16849327
Hgene	PTPRK	GO:0045786	negative regulation of cell cycle	15899872
Hgene	PTPRK	GO:0045892	negative regulation of transcription, DNA-templated	18276111

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	RV	SKCM	TCGA-EB-A5KH-06A	PTPRK	chr6	128505577	-	EYA4	chr6	133782252	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000368226	ENST00000452339	PTPRK	chr6	128505577	-	EYA4	chr6	133782252	+
In-frame	ENST00000368226	ENST00000430974	PTPRK	chr6	128505577	-	EYA4	chr6	133782252	+
In-frame	ENST00000368226	ENST00000367895	PTPRK	chr6	128505577	-	EYA4	chr6	133782252	+
In-frame	ENST00000368226	ENST00000355167	PTPRK	chr6	128505577	-	EYA4	chr6	133782252	+
In-frame	ENST00000368226	ENST00000355286	PTPRK	chr6	128505577	-	EYA4	chr6	133782252	+
In-frame	ENST00000368226	ENST00000531901	PTPRK	chr6	128505577	-	EYA4	chr6	133782252	+
In-frame	ENST00000368226	ENST00000525849	PTPRK	chr6	128505577	-	EYA4	chr6	133782252	+
In-frame	ENST00000368226	ENST00000431403	PTPRK	chr6	128505577	-	EYA4	chr6	133782252	+
5CDS-intron	ENST00000368226	ENST00000441015	PTPRK	chr6	128505577	-	EYA4	chr6	133782252	+
In-frame	ENST00000368227	ENST00000452339	PTPRK	chr6	128505577	-	EYA4	chr6	133782252	+
In-frame	ENST00000368227	ENST00000430974	PTPRK	chr6	128505577	-	EYA4	chr6	133782252	+
In-frame	ENST00000368227	ENST00000367895	PTPRK	chr6	128505577	-	EYA4	chr6	133782252	+
In-frame	ENST00000368227	ENST00000355167	PTPRK	chr6	128505577	-	EYA4	chr6	133782252	+
In-frame	ENST00000368227	ENST00000355286	PTPRK	chr6	128505577	-	EYA4	chr6	133782252	+
In-frame	ENST00000368227	ENST00000531901	PTPRK	chr6	128505577	-	EYA4	chr6	133782252	+
In-frame	ENST00000368227	ENST00000525849	PTPRK	chr6	128505577	-	EYA4	chr6	133782252	+
In-frame	ENST00000368227	ENST00000431403	PTPRK	chr6	128505577	-	EYA4	chr6	133782252	+
5CDS-intron	ENST00000368227	ENST00000441015	PTPRK	chr6	128505577	-	EYA4	chr6	133782252	+
In-frame	ENST00000532331	ENST00000452339	PTPRK	chr6	128505577	-	EYA4	chr6	133782252	+
In-frame	ENST00000532331	ENST00000430974	PTPRK	chr6	128505577	-	EYA4	chr6	133782252	+
In-frame	ENST00000532331	ENST00000367895	PTPRK	chr6	128505577	-	EYA4	chr6	133782252	+
In-frame	ENST00000532331	ENST00000355167	PTPRK	chr6	128505577	-	EYA4	chr6	133782252	+
In-frame	ENST00000532331	ENST00000355286	PTPRK	chr6	128505577	-	EYA4	chr6	133782252	+
In-frame	ENST00000532331	ENST00000531901	PTPRK	chr6	128505577	-	EYA4	chr6	133782252	+
In-frame	ENST00000532331	ENST00000525849	PTPRK	chr6	128505577	-	EYA4	chr6	133782252	+
In-frame	ENST00000532331	ENST00000431403	PTPRK	chr6	128505577	-	EYA4	chr6	133782252	+
5CDS-intron	ENST00000532331	ENST00000441015	PTPRK	chr6	128505577	-	EYA4	chr6	133782252	+
In-frame	ENST00000368213	ENST00000452339	PTPRK	chr6	128505577	-	EYA4	chr6	133782252	+
In-frame	ENST00000368213	ENST00000430974	PTPRK	chr6	128505577	-	EYA4	chr6	133782252	+
In-frame	ENST00000368213	ENST00000367895	PTPRK	chr6	128505577	-	EYA4	chr6	133782252	+
In-frame	ENST00000368213	ENST00000355167	PTPRK	chr6	128505577	-	EYA4	chr6	133782252	+
In-frame	ENST00000368213	ENST00000355286	PTPRK	chr6	128505577	-	EYA4	chr6	133782252	+
In-frame	ENST00000368213	ENST00000531901	PTPRK	chr6	128505577	-	EYA4	chr6	133782252	+
In-frame	ENST00000368213	ENST00000525849	PTPRK	chr6	128505577	-	EYA4	chr6	133782252	+
In-frame	ENST00000368213	ENST00000431403	PTPRK	chr6	128505577	-	EYA4	chr6	133782252	+
5CDS-intron	ENST00000368213	ENST00000441015	PTPRK	chr6	128505577	-	EYA4	chr6	133782252	+
In-frame	ENST00000368210	ENST00000452339	PTPRK	chr6	128505577	-	EYA4	chr6	133782252	+
In-frame	ENST00000368210	ENST00000430974	PTPRK	chr6	128505577	-	EYA4	chr6	133782252	+
In-frame	ENST00000368210	ENST00000367895	PTPRK	chr6	128505577	-	EYA4	chr6	133782252	+
In-frame	ENST00000368210	ENST00000355167	PTPRK	chr6	128505577	-	EYA4	chr6	133782252	+
In-frame	ENST00000368210	ENST00000355286	PTPRK	chr6	128505577	-	EYA4	chr6	133782252	+
In-frame	ENST00000368210	ENST00000531901	PTPRK	chr6	128505577	-	EYA4	chr6	133782252	+
In-frame	ENST00000368210	ENST00000525849	PTPRK	chr6	128505577	-	EYA4	chr6	133782252	+
In-frame	ENST00000368210	ENST00000431403	PTPRK	chr6	128505577	-	EYA4	chr6	133782252	+
5CDS-intron	ENST00000368210	ENST00000441015	PTPRK	chr6	128505577	-	EYA4	chr6	133782252	+
In-frame	ENST00000368215	ENST00000452339	PTPRK	chr6	128505577	-	EYA4	chr6	133782252	+
In-frame	ENST00000368215	ENST00000430974	PTPRK	chr6	128505577	-	EYA4	chr6	133782252	+
In-frame	ENST00000368215	ENST00000367895	PTPRK	chr6	128505577	-	EYA4	chr6	133782252	+
In-frame	ENST00000368215	ENST00000355167	PTPRK	chr6	128505577	-	EYA4	chr6	133782252	+
In-frame	ENST00000368215	ENST00000355286	PTPRK	chr6	128505577	-	EYA4	chr6	133782252	+
In-frame	ENST00000368215	ENST00000531901	PTPRK	chr6	128505577	-	EYA4	chr6	133782252	+
In-frame	ENST00000368215	ENST00000525849	PTPRK	chr6	128505577	-	EYA4	chr6	133782252	+
In-frame	ENST00000368215	ENST00000431403	PTPRK	chr6	128505577	-	EYA4	chr6	133782252	+
5CDS-intron	ENST00000368215	ENST00000441015	PTPRK	chr6	128505577	-	EYA4	chr6	133782252	+
In-frame	ENST00000368207	ENST00000452339	PTPRK	chr6	128505577	-	EYA4	chr6	133782252	+
In-frame	ENST00000368207	ENST00000430974	PTPRK	chr6	128505577	-	EYA4	chr6	133782252	+
In-frame	ENST00000368207	ENST00000367895	PTPRK	chr6	128505577	-	EYA4	chr6	133782252	+
In-frame	ENST00000368207	ENST00000355167	PTPRK	chr6	128505577	-	EYA4	chr6	133782252	+
In-frame	ENST00000368207	ENST00000355286	PTPRK	chr6	128505577	-	EYA4	chr6	133782252	+
In-frame	ENST00000368207	ENST00000531901	PTPRK	chr6	128505577	-	EYA4	chr6	133782252	+
In-frame	ENST00000368207	ENST00000525849	PTPRK	chr6	128505577	-	EYA4	chr6	133782252	+
In-frame	ENST00000368207	ENST00000431403	PTPRK	chr6	128505577	-	EYA4	chr6	133782252	+
5CDS-intron	ENST00000368207	ENST00000441015	PTPRK	chr6	128505577	-	EYA4	chr6	133782252	+
5UTR-3CDS	ENST00000524481	ENST00000452339	PTPRK	chr6	128505577	-	EYA4	chr6	133782252	+
5UTR-3CDS	ENST00000524481	ENST00000430974	PTPRK	chr6	128505577	-	EYA4	chr6	133782252	+
5UTR-3CDS	ENST00000524481	ENST00000367895	PTPRK	chr6	128505577	-	EYA4	chr6	133782252	+
5UTR-3CDS	ENST00000524481	ENST00000355167	PTPRK	chr6	128505577	-	EYA4	chr6	133782252	+
5UTR-3CDS	ENST00000524481	ENST00000355286	PTPRK	chr6	128505577	-	EYA4	chr6	133782252	+
5UTR-3CDS	ENST00000524481	ENST00000531901	PTPRK	chr6	128505577	-	EYA4	chr6	133782252	+
5UTR-3CDS	ENST00000524481	ENST00000525849	PTPRK	chr6	128505577	-	EYA4	chr6	133782252	+
5UTR-3CDS	ENST00000524481	ENST00000431403	PTPRK	chr6	128505577	-	EYA4	chr6	133782252	+
5UTR-intron	ENST00000524481	ENST00000441015	PTPRK	chr6	128505577	-	EYA4	chr6	133782252	+
intron-3CDS	ENST00000525459	ENST00000452339	PTPRK	chr6	128505577	-	EYA4	chr6	133782252	+
intron-3CDS	ENST00000525459	ENST00000430974	PTPRK	chr6	128505577	-	EYA4	chr6	133782252	+
intron-3CDS	ENST00000525459	ENST00000367895	PTPRK	chr6	128505577	-	EYA4	chr6	133782252	+
intron-3CDS	ENST00000525459	ENST00000355167	PTPRK	chr6	128505577	-	EYA4	chr6	133782252	+
intron-3CDS	ENST00000525459	ENST00000355286	PTPRK	chr6	128505577	-	EYA4	chr6	133782252	+
intron-3CDS	ENST00000525459	ENST00000531901	PTPRK	chr6	128505577	-	EYA4	chr6	133782252	+
intron-3CDS	ENST00000525459	ENST00000525849	PTPRK	chr6	128505577	-	EYA4	chr6	133782252	+
intron-3CDS	ENST00000525459	ENST00000431403	PTPRK	chr6	128505577	-	EYA4	chr6	133782252	+
intron-intron	ENST00000525459	ENST00000441015	PTPRK	chr6	128505577	-	EYA4	chr6	133782252	+

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FusionProtFeatures for PTPRK_EYA4

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
PTPRK Q15262	EYA4 O95677

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Fusion gene ID: 29535

FusionGeneSummary for PTPRK_EYA4

FusionProtFeatures for PTPRK_EYA4