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Fusion gene ID: 29483 |
FusionGeneSummary for PTPRA_SDAD1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PTPRA_SDAD1 | Fusion gene ID: 29483 | Hgene | Tgene | Gene symbol | PTPRA | SDAD1 | Gene ID | 5786 | 55153 |
| Gene name | protein tyrosine phosphatase, receptor type A | SDA1 domain containing 1 | |
| Synonyms | HEPTP|HLPR|HPTPA|HPTPalpha|LRP|PTPA|PTPRL2|R-PTP-alpha|RPTPA | - | |
| Cytomap | 20p13 | 4q21.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | receptor-type tyrosine-protein phosphatase alphaLeukocyte common antigen-related peptide (protein tyrosine phosphate)PTPLCA-related phosphatasePTPase-alphaprotein tyrosine phosphatase, receptor type, alpha polypeptideprotein-tyrosine phosphatase alph | protein SDA1 homologSDA1 domain-containing protein 1nucleolar protein 130 | |
| Modification date | 20180527 | 20180523 | |
| UniProtAcc | P18433 | Q9NVU7 | |
| Ensembl transtripts involved in fusion gene | ENST00000380393, ENST00000216877, ENST00000358719, ENST00000399903, ENST00000425918, ENST00000318266, ENST00000356147, | ENST00000356260, ENST00000395711, ENST00000513089, | |
| Fusion gene scores | * DoF score | 13 X 10 X 8=1040 | 1 X 1 X 1=1 |
| # samples | 14 | 1 | |
| ** MAII score | log2(14/1040*10)=-2.89308479608349 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: PTPRA [Title/Abstract] AND SDAD1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LUSC | TCGA-22-A5C4-01A | PTPRA | chr20 | 3018775 | + | SDAD1 | chr4 | 76879094 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000380393 | ENST00000356260 | PTPRA | chr20 | 3018775 | + | SDAD1 | chr4 | 76879094 | - |
| In-frame | ENST00000380393 | ENST00000395711 | PTPRA | chr20 | 3018775 | + | SDAD1 | chr4 | 76879094 | - |
| 5CDS-intron | ENST00000380393 | ENST00000513089 | PTPRA | chr20 | 3018775 | + | SDAD1 | chr4 | 76879094 | - |
| In-frame | ENST00000216877 | ENST00000356260 | PTPRA | chr20 | 3018775 | + | SDAD1 | chr4 | 76879094 | - |
| In-frame | ENST00000216877 | ENST00000395711 | PTPRA | chr20 | 3018775 | + | SDAD1 | chr4 | 76879094 | - |
| 5CDS-intron | ENST00000216877 | ENST00000513089 | PTPRA | chr20 | 3018775 | + | SDAD1 | chr4 | 76879094 | - |
| In-frame | ENST00000358719 | ENST00000356260 | PTPRA | chr20 | 3018775 | + | SDAD1 | chr4 | 76879094 | - |
| In-frame | ENST00000358719 | ENST00000395711 | PTPRA | chr20 | 3018775 | + | SDAD1 | chr4 | 76879094 | - |
| 5CDS-intron | ENST00000358719 | ENST00000513089 | PTPRA | chr20 | 3018775 | + | SDAD1 | chr4 | 76879094 | - |
| In-frame | ENST00000399903 | ENST00000356260 | PTPRA | chr20 | 3018775 | + | SDAD1 | chr4 | 76879094 | - |
| In-frame | ENST00000399903 | ENST00000395711 | PTPRA | chr20 | 3018775 | + | SDAD1 | chr4 | 76879094 | - |
| 5CDS-intron | ENST00000399903 | ENST00000513089 | PTPRA | chr20 | 3018775 | + | SDAD1 | chr4 | 76879094 | - |
| Frame-shift | ENST00000425918 | ENST00000356260 | PTPRA | chr20 | 3018775 | + | SDAD1 | chr4 | 76879094 | - |
| Frame-shift | ENST00000425918 | ENST00000395711 | PTPRA | chr20 | 3018775 | + | SDAD1 | chr4 | 76879094 | - |
| 5CDS-intron | ENST00000425918 | ENST00000513089 | PTPRA | chr20 | 3018775 | + | SDAD1 | chr4 | 76879094 | - |
| In-frame | ENST00000318266 | ENST00000356260 | PTPRA | chr20 | 3018775 | + | SDAD1 | chr4 | 76879094 | - |
| In-frame | ENST00000318266 | ENST00000395711 | PTPRA | chr20 | 3018775 | + | SDAD1 | chr4 | 76879094 | - |
| 5CDS-intron | ENST00000318266 | ENST00000513089 | PTPRA | chr20 | 3018775 | + | SDAD1 | chr4 | 76879094 | - |
| In-frame | ENST00000356147 | ENST00000356260 | PTPRA | chr20 | 3018775 | + | SDAD1 | chr4 | 76879094 | - |
| In-frame | ENST00000356147 | ENST00000395711 | PTPRA | chr20 | 3018775 | + | SDAD1 | chr4 | 76879094 | - |
| 5CDS-intron | ENST00000356147 | ENST00000513089 | PTPRA | chr20 | 3018775 | + | SDAD1 | chr4 | 76879094 | - |
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FusionProtFeatures for PTPRA_SDAD1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PTPRA | SDAD1 |