|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 29465 |
FusionGeneSummary for PTPN6_PTPN6 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PTPN6_PTPN6 | Fusion gene ID: 29465 | Hgene | Tgene | Gene symbol | PTPN6 | PTPN6 | Gene ID | 5777 | 5777 |
| Gene name | protein tyrosine phosphatase, non-receptor type 6 | protein tyrosine phosphatase, non-receptor type 6 | |
| Synonyms | HCP|HCPH|HPTP1C|PTP-1C|SH-PTP1|SHP-1|SHP-1L|SHP1 | HCP|HCPH|HPTP1C|PTP-1C|SH-PTP1|SHP-1|SHP-1L|SHP1 | |
| Cytomap | 12p13.31 | 12p13.31 | |
| Type of gene | protein-coding | protein-coding | |
| Description | tyrosine-protein phosphatase non-receptor type 6hematopoietic cell phosphatasehematopoietic cell protein-tyrosine phosphataseprotein-tyrosine phosphatase 1Cprotein-tyrosine phosphatase SHP-1 | tyrosine-protein phosphatase non-receptor type 6hematopoietic cell phosphatasehematopoietic cell protein-tyrosine phosphataseprotein-tyrosine phosphatase 1Cprotein-tyrosine phosphatase SHP-1 | |
| Modification date | 20180527 | 20180527 | |
| UniProtAcc | P29350 | P29350 | |
| Ensembl transtripts involved in fusion gene | ENST00000399448, ENST00000447931, ENST00000318974, ENST00000456013, ENST00000539029, | ENST00000399448, ENST00000447931, ENST00000318974, ENST00000456013, ENST00000539029, | |
| Fusion gene scores | * DoF score | 4 X 4 X 2=32 | 4 X 4 X 3=48 |
| # samples | 4 | 4 | |
| ** MAII score | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: PTPN6 [Title/Abstract] AND PTPN6 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | PTPN6 | GO:0006470 | protein dephosphorylation | 11266449 |
| Hgene | PTPN6 | GO:0008283 | cell proliferation | 11266449 |
| Hgene | PTPN6 | GO:0018108 | peptidyl-tyrosine phosphorylation | 9285411|18802077 |
| Hgene | PTPN6 | GO:0030154 | cell differentiation | 11266449 |
| Hgene | PTPN6 | GO:0070372 | regulation of ERK1 and ERK2 cascade | 11266449 |
| Tgene | PTPN6 | GO:0006470 | protein dephosphorylation | 11266449 |
| Tgene | PTPN6 | GO:0008283 | cell proliferation | 11266449 |
| Tgene | PTPN6 | GO:0018108 | peptidyl-tyrosine phosphorylation | 9285411|18802077 |
| Tgene | PTPN6 | GO:0030154 | cell differentiation | 11266449 |
| Tgene | PTPN6 | GO:0070372 | regulation of ERK1 and ERK2 cascade | 11266449 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BF762332 | PTPN6 | chr12 | 7065630 | + | PTPN6 | chr12 | 7064352 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000399448 | ENST00000399448 | PTPN6 | chr12 | 7065630 | + | PTPN6 | chr12 | 7064352 | + |
| In-frame | ENST00000399448 | ENST00000447931 | PTPN6 | chr12 | 7065630 | + | PTPN6 | chr12 | 7064352 | + |
| In-frame | ENST00000399448 | ENST00000318974 | PTPN6 | chr12 | 7065630 | + | PTPN6 | chr12 | 7064352 | + |
| In-frame | ENST00000399448 | ENST00000456013 | PTPN6 | chr12 | 7065630 | + | PTPN6 | chr12 | 7064352 | + |
| 5CDS-intron | ENST00000399448 | ENST00000539029 | PTPN6 | chr12 | 7065630 | + | PTPN6 | chr12 | 7064352 | + |
| In-frame | ENST00000447931 | ENST00000399448 | PTPN6 | chr12 | 7065630 | + | PTPN6 | chr12 | 7064352 | + |
| In-frame | ENST00000447931 | ENST00000447931 | PTPN6 | chr12 | 7065630 | + | PTPN6 | chr12 | 7064352 | + |
| In-frame | ENST00000447931 | ENST00000318974 | PTPN6 | chr12 | 7065630 | + | PTPN6 | chr12 | 7064352 | + |
| In-frame | ENST00000447931 | ENST00000456013 | PTPN6 | chr12 | 7065630 | + | PTPN6 | chr12 | 7064352 | + |
| 5CDS-intron | ENST00000447931 | ENST00000539029 | PTPN6 | chr12 | 7065630 | + | PTPN6 | chr12 | 7064352 | + |
| In-frame | ENST00000318974 | ENST00000399448 | PTPN6 | chr12 | 7065630 | + | PTPN6 | chr12 | 7064352 | + |
| In-frame | ENST00000318974 | ENST00000447931 | PTPN6 | chr12 | 7065630 | + | PTPN6 | chr12 | 7064352 | + |
| In-frame | ENST00000318974 | ENST00000318974 | PTPN6 | chr12 | 7065630 | + | PTPN6 | chr12 | 7064352 | + |
| In-frame | ENST00000318974 | ENST00000456013 | PTPN6 | chr12 | 7065630 | + | PTPN6 | chr12 | 7064352 | + |
| 5CDS-intron | ENST00000318974 | ENST00000539029 | PTPN6 | chr12 | 7065630 | + | PTPN6 | chr12 | 7064352 | + |
| In-frame | ENST00000456013 | ENST00000399448 | PTPN6 | chr12 | 7065630 | + | PTPN6 | chr12 | 7064352 | + |
| In-frame | ENST00000456013 | ENST00000447931 | PTPN6 | chr12 | 7065630 | + | PTPN6 | chr12 | 7064352 | + |
| In-frame | ENST00000456013 | ENST00000318974 | PTPN6 | chr12 | 7065630 | + | PTPN6 | chr12 | 7064352 | + |
| In-frame | ENST00000456013 | ENST00000456013 | PTPN6 | chr12 | 7065630 | + | PTPN6 | chr12 | 7064352 | + |
| 5CDS-intron | ENST00000456013 | ENST00000539029 | PTPN6 | chr12 | 7065630 | + | PTPN6 | chr12 | 7064352 | + |
| intron-3CDS | ENST00000539029 | ENST00000399448 | PTPN6 | chr12 | 7065630 | + | PTPN6 | chr12 | 7064352 | + |
| intron-3CDS | ENST00000539029 | ENST00000447931 | PTPN6 | chr12 | 7065630 | + | PTPN6 | chr12 | 7064352 | + |
| intron-3CDS | ENST00000539029 | ENST00000318974 | PTPN6 | chr12 | 7065630 | + | PTPN6 | chr12 | 7064352 | + |
| intron-3CDS | ENST00000539029 | ENST00000456013 | PTPN6 | chr12 | 7065630 | + | PTPN6 | chr12 | 7064352 | + |
| intron-intron | ENST00000539029 | ENST00000539029 | PTPN6 | chr12 | 7065630 | + | PTPN6 | chr12 | 7064352 | + |
Top |
FusionProtFeatures for PTPN6_PTPN6 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PTPN6 | PTPN6 |