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Fusion gene ID: 29454 |
FusionGeneSummary for PTPN3_ASTN2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PTPN3_ASTN2 | Fusion gene ID: 29454 | Hgene | Tgene | Gene symbol | PTPN3 | ASTN2 | Gene ID | 5774 | 23245 |
| Gene name | protein tyrosine phosphatase, non-receptor type 3 | astrotactin 2 | |
| Synonyms | PTP-H1|PTPH1 | bA67K19.1 | |
| Cytomap | 9q31.3 | 9q33.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | tyrosine-protein phosphatase non-receptor type 3cytoskeletal-associated protein tyrosine phosphataseprotein-tyrosine phosphatase H1 | astrotactin-2 | |
| Modification date | 20180527 | 20180519 | |
| UniProtAcc | P26045 | O75129 | |
| Ensembl transtripts involved in fusion gene | ENST00000412145, ENST00000446349, ENST00000374541, ENST00000262539, ENST00000394827, ENST00000497739, | ENST00000373996, ENST00000313400, ENST00000361209, ENST00000361477, ENST00000288520, ENST00000341734, ENST00000358637, | |
| Fusion gene scores | * DoF score | 4 X 4 X 3=48 | 11 X 9 X 8=792 |
| # samples | 4 | 12 | |
| ** MAII score | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(12/792*10)=-2.72246602447109 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: PTPN3 [Title/Abstract] AND ASTN2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | PTPN3 | GO:0006470 | protein dephosphorylation | 10364224 |
| Hgene | PTPN3 | GO:0045930 | negative regulation of mitotic cell cycle | 10364224 |
| Hgene | PTPN3 | GO:0098902 | regulation of membrane depolarization during action potential | 16930557 |
| Hgene | PTPN3 | GO:2000649 | regulation of sodium ion transmembrane transporter activity | 16930557 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | MESO | TCGA-TS-A7OU-01B | PTPN3 | chr9 | 112207520 | - | ASTN2 | chr9 | 119903757 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000412145 | ENST00000373996 | PTPN3 | chr9 | 112207520 | - | ASTN2 | chr9 | 119903757 | - |
| In-frame | ENST00000412145 | ENST00000313400 | PTPN3 | chr9 | 112207520 | - | ASTN2 | chr9 | 119903757 | - |
| 5CDS-intron | ENST00000412145 | ENST00000361209 | PTPN3 | chr9 | 112207520 | - | ASTN2 | chr9 | 119903757 | - |
| 5CDS-intron | ENST00000412145 | ENST00000361477 | PTPN3 | chr9 | 112207520 | - | ASTN2 | chr9 | 119903757 | - |
| 5CDS-intron | ENST00000412145 | ENST00000288520 | PTPN3 | chr9 | 112207520 | - | ASTN2 | chr9 | 119903757 | - |
| 5CDS-intron | ENST00000412145 | ENST00000341734 | PTPN3 | chr9 | 112207520 | - | ASTN2 | chr9 | 119903757 | - |
| 5CDS-intron | ENST00000412145 | ENST00000358637 | PTPN3 | chr9 | 112207520 | - | ASTN2 | chr9 | 119903757 | - |
| In-frame | ENST00000446349 | ENST00000373996 | PTPN3 | chr9 | 112207520 | - | ASTN2 | chr9 | 119903757 | - |
| In-frame | ENST00000446349 | ENST00000313400 | PTPN3 | chr9 | 112207520 | - | ASTN2 | chr9 | 119903757 | - |
| 5CDS-intron | ENST00000446349 | ENST00000361209 | PTPN3 | chr9 | 112207520 | - | ASTN2 | chr9 | 119903757 | - |
| 5CDS-intron | ENST00000446349 | ENST00000361477 | PTPN3 | chr9 | 112207520 | - | ASTN2 | chr9 | 119903757 | - |
| 5CDS-intron | ENST00000446349 | ENST00000288520 | PTPN3 | chr9 | 112207520 | - | ASTN2 | chr9 | 119903757 | - |
| 5CDS-intron | ENST00000446349 | ENST00000341734 | PTPN3 | chr9 | 112207520 | - | ASTN2 | chr9 | 119903757 | - |
| 5CDS-intron | ENST00000446349 | ENST00000358637 | PTPN3 | chr9 | 112207520 | - | ASTN2 | chr9 | 119903757 | - |
| In-frame | ENST00000374541 | ENST00000373996 | PTPN3 | chr9 | 112207520 | - | ASTN2 | chr9 | 119903757 | - |
| In-frame | ENST00000374541 | ENST00000313400 | PTPN3 | chr9 | 112207520 | - | ASTN2 | chr9 | 119903757 | - |
| 5CDS-intron | ENST00000374541 | ENST00000361209 | PTPN3 | chr9 | 112207520 | - | ASTN2 | chr9 | 119903757 | - |
| 5CDS-intron | ENST00000374541 | ENST00000361477 | PTPN3 | chr9 | 112207520 | - | ASTN2 | chr9 | 119903757 | - |
| 5CDS-intron | ENST00000374541 | ENST00000288520 | PTPN3 | chr9 | 112207520 | - | ASTN2 | chr9 | 119903757 | - |
| 5CDS-intron | ENST00000374541 | ENST00000341734 | PTPN3 | chr9 | 112207520 | - | ASTN2 | chr9 | 119903757 | - |
| 5CDS-intron | ENST00000374541 | ENST00000358637 | PTPN3 | chr9 | 112207520 | - | ASTN2 | chr9 | 119903757 | - |
| In-frame | ENST00000262539 | ENST00000373996 | PTPN3 | chr9 | 112207520 | - | ASTN2 | chr9 | 119903757 | - |
| In-frame | ENST00000262539 | ENST00000313400 | PTPN3 | chr9 | 112207520 | - | ASTN2 | chr9 | 119903757 | - |
| 5CDS-intron | ENST00000262539 | ENST00000361209 | PTPN3 | chr9 | 112207520 | - | ASTN2 | chr9 | 119903757 | - |
| 5CDS-intron | ENST00000262539 | ENST00000361477 | PTPN3 | chr9 | 112207520 | - | ASTN2 | chr9 | 119903757 | - |
| 5CDS-intron | ENST00000262539 | ENST00000288520 | PTPN3 | chr9 | 112207520 | - | ASTN2 | chr9 | 119903757 | - |
| 5CDS-intron | ENST00000262539 | ENST00000341734 | PTPN3 | chr9 | 112207520 | - | ASTN2 | chr9 | 119903757 | - |
| 5CDS-intron | ENST00000262539 | ENST00000358637 | PTPN3 | chr9 | 112207520 | - | ASTN2 | chr9 | 119903757 | - |
| intron-3CDS | ENST00000394827 | ENST00000373996 | PTPN3 | chr9 | 112207520 | - | ASTN2 | chr9 | 119903757 | - |
| intron-3CDS | ENST00000394827 | ENST00000313400 | PTPN3 | chr9 | 112207520 | - | ASTN2 | chr9 | 119903757 | - |
| intron-intron | ENST00000394827 | ENST00000361209 | PTPN3 | chr9 | 112207520 | - | ASTN2 | chr9 | 119903757 | - |
| intron-intron | ENST00000394827 | ENST00000361477 | PTPN3 | chr9 | 112207520 | - | ASTN2 | chr9 | 119903757 | - |
| intron-intron | ENST00000394827 | ENST00000288520 | PTPN3 | chr9 | 112207520 | - | ASTN2 | chr9 | 119903757 | - |
| intron-intron | ENST00000394827 | ENST00000341734 | PTPN3 | chr9 | 112207520 | - | ASTN2 | chr9 | 119903757 | - |
| intron-intron | ENST00000394827 | ENST00000358637 | PTPN3 | chr9 | 112207520 | - | ASTN2 | chr9 | 119903757 | - |
| intron-3CDS | ENST00000497739 | ENST00000373996 | PTPN3 | chr9 | 112207520 | - | ASTN2 | chr9 | 119903757 | - |
| intron-3CDS | ENST00000497739 | ENST00000313400 | PTPN3 | chr9 | 112207520 | - | ASTN2 | chr9 | 119903757 | - |
| intron-intron | ENST00000497739 | ENST00000361209 | PTPN3 | chr9 | 112207520 | - | ASTN2 | chr9 | 119903757 | - |
| intron-intron | ENST00000497739 | ENST00000361477 | PTPN3 | chr9 | 112207520 | - | ASTN2 | chr9 | 119903757 | - |
| intron-intron | ENST00000497739 | ENST00000288520 | PTPN3 | chr9 | 112207520 | - | ASTN2 | chr9 | 119903757 | - |
| intron-intron | ENST00000497739 | ENST00000341734 | PTPN3 | chr9 | 112207520 | - | ASTN2 | chr9 | 119903757 | - |
| intron-intron | ENST00000497739 | ENST00000358637 | PTPN3 | chr9 | 112207520 | - | ASTN2 | chr9 | 119903757 | - |
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FusionProtFeatures for PTPN3_ASTN2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PTPN3 | ASTN2 |