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Fusion gene ID: 29432 |
FusionGeneSummary for PTPN1_ERF |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PTPN1_ERF | Fusion gene ID: 29432 | Hgene | Tgene | Gene symbol | PTPN1 | ERF | Gene ID | 5770 | 2107 |
| Gene name | protein tyrosine phosphatase, non-receptor type 1 | eukaryotic translation termination factor 1 | |
| Synonyms | PTP1B | D5S1995|ERF|ERF1|RF1|SUP45L1|TB3-1 | |
| Cytomap | 20q13.13 | 5q31.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | tyrosine-protein phosphatase non-receptor type 1protein tyrosine phosphatase, placentalprotein-tyrosine phosphatase 1B | eukaryotic peptide chain release factor subunit 1polypeptide chain release factor 1protein Cl1sup45 (yeast omnipotent suppressor 45) homolog-like 1 | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | P18031 | P50548 | |
| Ensembl transtripts involved in fusion gene | ENST00000371621, ENST00000541713, | ENST00000222329, ENST00000440177, ENST00000595941, | |
| Fusion gene scores | * DoF score | 7 X 4 X 5=140 | 1 X 1 X 1=1 |
| # samples | 8 | 1 | |
| ** MAII score | log2(8/140*10)=-0.807354922057604 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: PTPN1 [Title/Abstract] AND ERF [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | PTPN1 | GO:0030100 | regulation of endocytosis | 21135139 |
| Hgene | PTPN1 | GO:0030968 | endoplasmic reticulum unfolded protein response | 22169477 |
| Hgene | PTPN1 | GO:0035335 | peptidyl-tyrosine dephosphorylation | 21135139 |
| Hgene | PTPN1 | GO:0061098 | positive regulation of protein tyrosine kinase activity | 21216966 |
| Hgene | PTPN1 | GO:1903898 | negative regulation of PERK-mediated unfolded protein response | 21216966 |
| Tgene | ERF | GO:0006479 | protein methylation | 18539146 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BU682148 | PTPN1 | chr20 | 49201006 | - | ERF | chr19 | 42752229 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 3UTR-3UTR | ENST00000371621 | ENST00000222329 | PTPN1 | chr20 | 49201006 | - | ERF | chr19 | 42752229 | + |
| 3UTR-intron | ENST00000371621 | ENST00000440177 | PTPN1 | chr20 | 49201006 | - | ERF | chr19 | 42752229 | + |
| 3UTR-intron | ENST00000371621 | ENST00000595941 | PTPN1 | chr20 | 49201006 | - | ERF | chr19 | 42752229 | + |
| intron-3UTR | ENST00000541713 | ENST00000222329 | PTPN1 | chr20 | 49201006 | - | ERF | chr19 | 42752229 | + |
| intron-intron | ENST00000541713 | ENST00000440177 | PTPN1 | chr20 | 49201006 | - | ERF | chr19 | 42752229 | + |
| intron-intron | ENST00000541713 | ENST00000595941 | PTPN1 | chr20 | 49201006 | - | ERF | chr19 | 42752229 | + |
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FusionProtFeatures for PTPN1_ERF |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PTPN1 | ERF |