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Fusion gene ID: 29430 |
FusionGeneSummary for PTPN18_WIPI1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PTPN18_WIPI1 | Fusion gene ID: 29430 | Hgene | Tgene | Gene symbol | PTPN18 | WIPI1 | Gene ID | 26469 | 55062 |
| Gene name | protein tyrosine phosphatase, non-receptor type 18 | WD repeat domain, phosphoinositide interacting 1 | |
| Synonyms | BDP1|PTP-HSCF | ATG18|ATG18A|WIPI49 | |
| Cytomap | 2q21.1 | 17q24.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | tyrosine-protein phosphatase non-receptor type 18brain-derived phosphataseprotein tyrosine phosphatase, non-receptor type 18 (brain-derived) | WD repeat domain phosphoinositide-interacting protein 1WIPI-1 alphaatg18 protein homolog | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q99952 | Q5MNZ9 | |
| Ensembl transtripts involved in fusion gene | ENST00000175756, ENST00000347849, ENST00000420717, | ENST00000262139, ENST00000589459, ENST00000546360, | |
| Fusion gene scores | * DoF score | 3 X 3 X 1=9 | 5 X 5 X 2=50 |
| # samples | 3 | 5 | |
| ** MAII score | log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(5/50*10)=0 | |
| Context | PubMed: PTPN18 [Title/Abstract] AND WIPI1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | WIPI1 | GO:0048203 | vesicle targeting, trans-Golgi to endosome | 15020712 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BE694982 | PTPN18 | chr2 | 131131756 | + | WIPI1 | chr17 | 66417914 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 3UTR-3CDS | ENST00000175756 | ENST00000262139 | PTPN18 | chr2 | 131131756 | + | WIPI1 | chr17 | 66417914 | - |
| 3UTR-5UTR | ENST00000175756 | ENST00000589459 | PTPN18 | chr2 | 131131756 | + | WIPI1 | chr17 | 66417914 | - |
| 3UTR-5UTR | ENST00000175756 | ENST00000546360 | PTPN18 | chr2 | 131131756 | + | WIPI1 | chr17 | 66417914 | - |
| 3UTR-3CDS | ENST00000347849 | ENST00000262139 | PTPN18 | chr2 | 131131756 | + | WIPI1 | chr17 | 66417914 | - |
| 3UTR-5UTR | ENST00000347849 | ENST00000589459 | PTPN18 | chr2 | 131131756 | + | WIPI1 | chr17 | 66417914 | - |
| 3UTR-5UTR | ENST00000347849 | ENST00000546360 | PTPN18 | chr2 | 131131756 | + | WIPI1 | chr17 | 66417914 | - |
| intron-3CDS | ENST00000420717 | ENST00000262139 | PTPN18 | chr2 | 131131756 | + | WIPI1 | chr17 | 66417914 | - |
| intron-5UTR | ENST00000420717 | ENST00000589459 | PTPN18 | chr2 | 131131756 | + | WIPI1 | chr17 | 66417914 | - |
| intron-5UTR | ENST00000420717 | ENST00000546360 | PTPN18 | chr2 | 131131756 | + | WIPI1 | chr17 | 66417914 | - |
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FusionProtFeatures for PTPN18_WIPI1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PTPN18 | WIPI1 |