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Fusion gene ID: 29412 |
FusionGeneSummary for PTPN12_CKAP5 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PTPN12_CKAP5 | Fusion gene ID: 29412 | Hgene | Tgene | Gene symbol | PTPN12 | CKAP5 | Gene ID | 5782 | 9793 |
| Gene name | protein tyrosine phosphatase, non-receptor type 12 | cytoskeleton associated protein 5 | |
| Synonyms | PTP-PEST|PTPG1 | CHTOG|MSPS|TOG|TOGp|ch-TOG | |
| Cytomap | 7q11.23 | 11p11.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | tyrosine-protein phosphatase non-receptor type 12protein-tyrosine phosphatase G1 | cytoskeleton-associated protein 5colonic and hepatic tumor over-expressed gene proteincolonic and hepatic tumor overexpressed gene protein | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | Q05209 | Q14008 | |
| Ensembl transtripts involved in fusion gene | ENST00000248594, ENST00000415482, ENST00000435495, | ENST00000529230, ENST00000415402, ENST00000312055, ENST00000354558, ENST00000532321, | |
| Fusion gene scores | * DoF score | 9 X 8 X 5=360 | 8 X 8 X 5=320 |
| # samples | 11 | 10 | |
| ** MAII score | log2(11/360*10)=-1.71049338280502 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(10/320*10)=-1.67807190511264 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: PTPN12 [Title/Abstract] AND CKAP5 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | PTPN12 | GO:0006470 | protein dephosphorylation | 27134172 |
| Hgene | PTPN12 | GO:0035335 | peptidyl-tyrosine dephosphorylation | 27134172 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BE466787 | PTPN12 | chr7 | 77166725 | - | CKAP5 | chr11 | 46765654 | + | ||
| ChiTaRS3.1 | BF056903 | PTPN12 | chr7 | 77166725 | - | CKAP5 | chr11 | 46765654 | + | ||
| ChiTaRS3.1 | AI341063 | PTPN12 | chr7 | 77166725 | - | CKAP5 | chr11 | 46765654 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-3CDS | ENST00000248594 | ENST00000529230 | PTPN12 | chr7 | 77166725 | - | CKAP5 | chr11 | 46765654 | + |
| 5UTR-3CDS | ENST00000248594 | ENST00000415402 | PTPN12 | chr7 | 77166725 | - | CKAP5 | chr11 | 46765654 | + |
| 5UTR-3CDS | ENST00000248594 | ENST00000312055 | PTPN12 | chr7 | 77166725 | - | CKAP5 | chr11 | 46765654 | + |
| 5UTR-3CDS | ENST00000248594 | ENST00000354558 | PTPN12 | chr7 | 77166725 | - | CKAP5 | chr11 | 46765654 | + |
| 5UTR-intron | ENST00000248594 | ENST00000532321 | PTPN12 | chr7 | 77166725 | - | CKAP5 | chr11 | 46765654 | + |
| intron-3CDS | ENST00000415482 | ENST00000529230 | PTPN12 | chr7 | 77166725 | - | CKAP5 | chr11 | 46765654 | + |
| intron-3CDS | ENST00000415482 | ENST00000415402 | PTPN12 | chr7 | 77166725 | - | CKAP5 | chr11 | 46765654 | + |
| intron-3CDS | ENST00000415482 | ENST00000312055 | PTPN12 | chr7 | 77166725 | - | CKAP5 | chr11 | 46765654 | + |
| intron-3CDS | ENST00000415482 | ENST00000354558 | PTPN12 | chr7 | 77166725 | - | CKAP5 | chr11 | 46765654 | + |
| intron-intron | ENST00000415482 | ENST00000532321 | PTPN12 | chr7 | 77166725 | - | CKAP5 | chr11 | 46765654 | + |
| intron-3CDS | ENST00000435495 | ENST00000529230 | PTPN12 | chr7 | 77166725 | - | CKAP5 | chr11 | 46765654 | + |
| intron-3CDS | ENST00000435495 | ENST00000415402 | PTPN12 | chr7 | 77166725 | - | CKAP5 | chr11 | 46765654 | + |
| intron-3CDS | ENST00000435495 | ENST00000312055 | PTPN12 | chr7 | 77166725 | - | CKAP5 | chr11 | 46765654 | + |
| intron-3CDS | ENST00000435495 | ENST00000354558 | PTPN12 | chr7 | 77166725 | - | CKAP5 | chr11 | 46765654 | + |
| intron-intron | ENST00000435495 | ENST00000532321 | PTPN12 | chr7 | 77166725 | - | CKAP5 | chr11 | 46765654 | + |
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FusionProtFeatures for PTPN12_CKAP5 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PTPN12 | CKAP5 |