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Fusion gene ID: 29409 |
FusionGeneSummary for PTPN11_ZNF706 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PTPN11_ZNF706 | Fusion gene ID: 29409 | Hgene | Tgene | Gene symbol | PTPN11 | ZNF706 | Gene ID | 5781 | 51123 |
| Gene name | protein tyrosine phosphatase, non-receptor type 11 | zinc finger protein 706 | |
| Synonyms | BPTP3|CFC|JMML|METCDS|NS1|PTP-1D|PTP2C|SH-PTP2|SH-PTP3|SHP2 | HSPC038|PNAS-106|PNAS-113 | |
| Cytomap | 12q24.13 | 8q22.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | tyrosine-protein phosphatase non-receptor type 11PTP-2Cprotein-tyrosine phosphatase 1Dprotein-tyrosine phosphatase 2C | zinc finger protein 706 | |
| Modification date | 20180527 | 20180519 | |
| UniProtAcc | Q06124 | Q9Y5V0 | |
| Ensembl transtripts involved in fusion gene | ENST00000531326, ENST00000392597, ENST00000351677, | ENST00000520984, ENST00000311212, ENST00000519744, ENST00000517844, ENST00000520347, ENST00000519882, ENST00000521272, ENST00000518336, | |
| Fusion gene scores | * DoF score | 7 X 6 X 4=168 | 5 X 4 X 4=80 |
| # samples | 6 | 5 | |
| ** MAII score | log2(6/168*10)=-1.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/80*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: PTPN11 [Title/Abstract] AND ZNF706 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | PTPN11 | GO:0035335 | peptidyl-tyrosine dephosphorylation | 15133037 |
| Hgene | PTPN11 | GO:0038127 | ERBB signaling pathway | 15133037 |
| Hgene | PTPN11 | GO:0043254 | regulation of protein complex assembly | 7493946 |
| Hgene | PTPN11 | GO:0048013 | ephrin receptor signaling pathway | 10655584 |
| Hgene | PTPN11 | GO:2001275 | positive regulation of glucose import in response to insulin stimulus | 7493946 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BLCA | TCGA-2F-A9KW-01A | PTPN11 | chr12 | 112856929 | + | ZNF706 | chr8 | 102213971 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-5UTR | ENST00000531326 | ENST00000520984 | PTPN11 | chr12 | 112856929 | + | ZNF706 | chr8 | 102213971 | - |
| intron-5UTR | ENST00000531326 | ENST00000311212 | PTPN11 | chr12 | 112856929 | + | ZNF706 | chr8 | 102213971 | - |
| intron-5UTR | ENST00000531326 | ENST00000519744 | PTPN11 | chr12 | 112856929 | + | ZNF706 | chr8 | 102213971 | - |
| intron-5UTR | ENST00000531326 | ENST00000517844 | PTPN11 | chr12 | 112856929 | + | ZNF706 | chr8 | 102213971 | - |
| intron-5UTR | ENST00000531326 | ENST00000520347 | PTPN11 | chr12 | 112856929 | + | ZNF706 | chr8 | 102213971 | - |
| intron-5UTR | ENST00000531326 | ENST00000519882 | PTPN11 | chr12 | 112856929 | + | ZNF706 | chr8 | 102213971 | - |
| intron-5UTR | ENST00000531326 | ENST00000521272 | PTPN11 | chr12 | 112856929 | + | ZNF706 | chr8 | 102213971 | - |
| intron-5UTR | ENST00000531326 | ENST00000518336 | PTPN11 | chr12 | 112856929 | + | ZNF706 | chr8 | 102213971 | - |
| 5CDS-5UTR | ENST00000392597 | ENST00000520984 | PTPN11 | chr12 | 112856929 | + | ZNF706 | chr8 | 102213971 | - |
| 5CDS-5UTR | ENST00000392597 | ENST00000311212 | PTPN11 | chr12 | 112856929 | + | ZNF706 | chr8 | 102213971 | - |
| 5CDS-5UTR | ENST00000392597 | ENST00000519744 | PTPN11 | chr12 | 112856929 | + | ZNF706 | chr8 | 102213971 | - |
| 5CDS-5UTR | ENST00000392597 | ENST00000517844 | PTPN11 | chr12 | 112856929 | + | ZNF706 | chr8 | 102213971 | - |
| 5CDS-5UTR | ENST00000392597 | ENST00000520347 | PTPN11 | chr12 | 112856929 | + | ZNF706 | chr8 | 102213971 | - |
| 5CDS-5UTR | ENST00000392597 | ENST00000519882 | PTPN11 | chr12 | 112856929 | + | ZNF706 | chr8 | 102213971 | - |
| 5CDS-5UTR | ENST00000392597 | ENST00000521272 | PTPN11 | chr12 | 112856929 | + | ZNF706 | chr8 | 102213971 | - |
| 5CDS-5UTR | ENST00000392597 | ENST00000518336 | PTPN11 | chr12 | 112856929 | + | ZNF706 | chr8 | 102213971 | - |
| 5CDS-5UTR | ENST00000351677 | ENST00000520984 | PTPN11 | chr12 | 112856929 | + | ZNF706 | chr8 | 102213971 | - |
| 5CDS-5UTR | ENST00000351677 | ENST00000311212 | PTPN11 | chr12 | 112856929 | + | ZNF706 | chr8 | 102213971 | - |
| 5CDS-5UTR | ENST00000351677 | ENST00000519744 | PTPN11 | chr12 | 112856929 | + | ZNF706 | chr8 | 102213971 | - |
| 5CDS-5UTR | ENST00000351677 | ENST00000517844 | PTPN11 | chr12 | 112856929 | + | ZNF706 | chr8 | 102213971 | - |
| 5CDS-5UTR | ENST00000351677 | ENST00000520347 | PTPN11 | chr12 | 112856929 | + | ZNF706 | chr8 | 102213971 | - |
| 5CDS-5UTR | ENST00000351677 | ENST00000519882 | PTPN11 | chr12 | 112856929 | + | ZNF706 | chr8 | 102213971 | - |
| 5CDS-5UTR | ENST00000351677 | ENST00000521272 | PTPN11 | chr12 | 112856929 | + | ZNF706 | chr8 | 102213971 | - |
| 5CDS-5UTR | ENST00000351677 | ENST00000518336 | PTPN11 | chr12 | 112856929 | + | ZNF706 | chr8 | 102213971 | - |
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FusionProtFeatures for PTPN11_ZNF706 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PTPN11 | ZNF706 |