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Fusion gene ID: 29363

FusionGeneSummary for PTK7_ANKS1A

Fusion gene summary

Fusion gene information	Fusion gene name: PTK7_ANKS1A
	Fusion gene ID: 29363
		Hgene	Tgene
	Gene symbol	PTK7	ANKS1A
	Gene ID	5754	23294
	Gene name	protein tyrosine kinase 7 (inactive)	ankyrin repeat and sterile alpha motif domain containing 1A
	Synonyms	CCK-4\|CCK4	ANKS1
	Cytomap	6p21.1	6p21.31
	Type of gene	protein-coding	protein-coding
	Description	inactive tyrosine-protein kinase 7PTK7 protein tyrosine kinase 7colon carcinoma kinase 4pseudo tyrosine kinase receptor 7tyrosine-protein kinase-like 7	ankyrin repeat and SAM domain-containing protein 1AOdinankyrin repeat and SAM domain containing 1
	Modification date	20180523	20180522
	UniProtAcc	Q13308	Q92625
	Ensembl transtripts involved in fusion gene	ENST00000230419, ENST00000349241, ENST00000345201, ENST00000352931, ENST00000481273, ENST00000476760, ENST00000471863,	ENST00000360359, ENST00000535627, ENST00000470698,
Fusion gene scores	* DoF score	10 X 3 X 10=300	26 X 6 X 14=2184
	# samples	10	28
	** MAII score	log2(10/300*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(28/2184*10)=-2.96347412397489 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: PTK7 [Title/Abstract] AND ANKS1A [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	RV	HNSC	TCGA-BA-4078-01A	PTK7	chr6	43044305	+	ANKS1A	chr6	34935016	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
Frame-shift	ENST00000230419	ENST00000360359	PTK7	chr6	43044305	+	ANKS1A	chr6	34935016	+
Frame-shift	ENST00000230419	ENST00000535627	PTK7	chr6	43044305	+	ANKS1A	chr6	34935016	+
5CDS-intron	ENST00000230419	ENST00000470698	PTK7	chr6	43044305	+	ANKS1A	chr6	34935016	+
Frame-shift	ENST00000349241	ENST00000360359	PTK7	chr6	43044305	+	ANKS1A	chr6	34935016	+
Frame-shift	ENST00000349241	ENST00000535627	PTK7	chr6	43044305	+	ANKS1A	chr6	34935016	+
5CDS-intron	ENST00000349241	ENST00000470698	PTK7	chr6	43044305	+	ANKS1A	chr6	34935016	+
Frame-shift	ENST00000345201	ENST00000360359	PTK7	chr6	43044305	+	ANKS1A	chr6	34935016	+
Frame-shift	ENST00000345201	ENST00000535627	PTK7	chr6	43044305	+	ANKS1A	chr6	34935016	+
5CDS-intron	ENST00000345201	ENST00000470698	PTK7	chr6	43044305	+	ANKS1A	chr6	34935016	+
Frame-shift	ENST00000352931	ENST00000360359	PTK7	chr6	43044305	+	ANKS1A	chr6	34935016	+
Frame-shift	ENST00000352931	ENST00000535627	PTK7	chr6	43044305	+	ANKS1A	chr6	34935016	+
5CDS-intron	ENST00000352931	ENST00000470698	PTK7	chr6	43044305	+	ANKS1A	chr6	34935016	+
intron-3CDS	ENST00000481273	ENST00000360359	PTK7	chr6	43044305	+	ANKS1A	chr6	34935016	+
intron-3CDS	ENST00000481273	ENST00000535627	PTK7	chr6	43044305	+	ANKS1A	chr6	34935016	+
intron-intron	ENST00000481273	ENST00000470698	PTK7	chr6	43044305	+	ANKS1A	chr6	34935016	+
Frame-shift	ENST00000476760	ENST00000360359	PTK7	chr6	43044305	+	ANKS1A	chr6	34935016	+
Frame-shift	ENST00000476760	ENST00000535627	PTK7	chr6	43044305	+	ANKS1A	chr6	34935016	+
5CDS-intron	ENST00000476760	ENST00000470698	PTK7	chr6	43044305	+	ANKS1A	chr6	34935016	+
Frame-shift	ENST00000471863	ENST00000360359	PTK7	chr6	43044305	+	ANKS1A	chr6	34935016	+
Frame-shift	ENST00000471863	ENST00000535627	PTK7	chr6	43044305	+	ANKS1A	chr6	34935016	+
5CDS-intron	ENST00000471863	ENST00000470698	PTK7	chr6	43044305	+	ANKS1A	chr6	34935016	+

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FusionProtFeatures for PTK7_ANKS1A

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
PTK7 Q13308	ANKS1A Q92625

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Fusion gene ID: 29363

FusionGeneSummary for PTK7_ANKS1A

FusionProtFeatures for PTK7_ANKS1A