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Fusion gene ID: 29347 |
FusionGeneSummary for PTK2_EIF3E |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PTK2_EIF3E | Fusion gene ID: 29347 | Hgene | Tgene | Gene symbol | PTK2 | EIF3E | Gene ID | 5747 | 3646 |
| Gene name | protein tyrosine kinase 2 | eukaryotic translation initiation factor 3 subunit E | |
| Synonyms | FADK|FAK|FAK1|FRNK|PPP1R71|p125FAK|pp125FAK | EIF3-P48|EIF3S6|INT6|eIF3-p46 | |
| Cytomap | 8q24.3 | 8q23.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | focal adhesion kinase 1FADK 1FAK-related non-kinase polypeptidePTK2 protein tyrosine kinase 2focal adhesion kinase isoform FAK-Del33focal adhesion kinase-related nonkinaseprotein phosphatase 1 regulatory subunit 71 | eukaryotic translation initiation factor 3 subunit EeIF-3 p48eukaryotic translation initiation factor 3 subunit 6eukaryotic translation initiation factor 3 subunit E isoform 2 transcripteukaryotic translation initiation factor 3, subunit 6 (48kD)euka | |
| Modification date | 20180527 | 20180523 | |
| UniProtAcc | Q05397 | P60228 | |
| Ensembl transtripts involved in fusion gene | ENST00000522684, ENST00000535192, ENST00000519465, ENST00000517887, ENST00000521059, ENST00000395218, ENST00000538769, ENST00000340930, ENST00000519419, ENST00000430260, ENST00000519881, ENST00000520892, ENST00000519635, ENST00000517712, ENST00000522950, ENST00000520151, | ENST00000220849, ENST00000519030, ENST00000519517, | |
| Fusion gene scores | * DoF score | 23 X 15 X 10=3450 | 4 X 2 X 4=32 |
| # samples | 25 | 4 | |
| ** MAII score | log2(25/3450*10)=-3.78659636189081 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: PTK2 [Title/Abstract] AND EIF3E [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | PTK2 | GO:0007179 | transforming growth factor beta receptor signaling pathway | 24036928 |
| Hgene | PTK2 | GO:0007229 | integrin-mediated signaling pathway | 24036928 |
| Hgene | PTK2 | GO:0018108 | peptidyl-tyrosine phosphorylation | 10655584|11331870 |
| Hgene | PTK2 | GO:0022408 | negative regulation of cell-cell adhesion | 21703394 |
| Hgene | PTK2 | GO:0030335 | positive regulation of cell migration | 11331870|21703394 |
| Hgene | PTK2 | GO:0033628 | regulation of cell adhesion mediated by integrin | 10655584 |
| Hgene | PTK2 | GO:0046777 | protein autophosphorylation | 10655584|11331870 |
| Hgene | PTK2 | GO:0048013 | ephrin receptor signaling pathway | 10655584 |
| Hgene | PTK2 | GO:0060396 | growth hormone receptor signaling pathway | 10925297 |
| Tgene | EIF3E | GO:0006413 | translational initiation | 17581632 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BLCA | TCGA-C4-A0F0-01A | PTK2 | chr8 | 142011224 | - | EIF3E | chr8 | 109321692 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-intron | ENST00000522684 | ENST00000220849 | PTK2 | chr8 | 142011224 | - | EIF3E | chr8 | 109321692 | - |
| 5UTR-intron | ENST00000522684 | ENST00000519030 | PTK2 | chr8 | 142011224 | - | EIF3E | chr8 | 109321692 | - |
| 5UTR-intron | ENST00000522684 | ENST00000519517 | PTK2 | chr8 | 142011224 | - | EIF3E | chr8 | 109321692 | - |
| intron-intron | ENST00000535192 | ENST00000220849 | PTK2 | chr8 | 142011224 | - | EIF3E | chr8 | 109321692 | - |
| intron-intron | ENST00000535192 | ENST00000519030 | PTK2 | chr8 | 142011224 | - | EIF3E | chr8 | 109321692 | - |
| intron-intron | ENST00000535192 | ENST00000519517 | PTK2 | chr8 | 142011224 | - | EIF3E | chr8 | 109321692 | - |
| intron-intron | ENST00000519465 | ENST00000220849 | PTK2 | chr8 | 142011224 | - | EIF3E | chr8 | 109321692 | - |
| intron-intron | ENST00000519465 | ENST00000519030 | PTK2 | chr8 | 142011224 | - | EIF3E | chr8 | 109321692 | - |
| intron-intron | ENST00000519465 | ENST00000519517 | PTK2 | chr8 | 142011224 | - | EIF3E | chr8 | 109321692 | - |
| intron-intron | ENST00000517887 | ENST00000220849 | PTK2 | chr8 | 142011224 | - | EIF3E | chr8 | 109321692 | - |
| intron-intron | ENST00000517887 | ENST00000519030 | PTK2 | chr8 | 142011224 | - | EIF3E | chr8 | 109321692 | - |
| intron-intron | ENST00000517887 | ENST00000519517 | PTK2 | chr8 | 142011224 | - | EIF3E | chr8 | 109321692 | - |
| 5UTR-intron | ENST00000521059 | ENST00000220849 | PTK2 | chr8 | 142011224 | - | EIF3E | chr8 | 109321692 | - |
| 5UTR-intron | ENST00000521059 | ENST00000519030 | PTK2 | chr8 | 142011224 | - | EIF3E | chr8 | 109321692 | - |
| 5UTR-intron | ENST00000521059 | ENST00000519517 | PTK2 | chr8 | 142011224 | - | EIF3E | chr8 | 109321692 | - |
| 5UTR-intron | ENST00000395218 | ENST00000220849 | PTK2 | chr8 | 142011224 | - | EIF3E | chr8 | 109321692 | - |
| 5UTR-intron | ENST00000395218 | ENST00000519030 | PTK2 | chr8 | 142011224 | - | EIF3E | chr8 | 109321692 | - |
| 5UTR-intron | ENST00000395218 | ENST00000519517 | PTK2 | chr8 | 142011224 | - | EIF3E | chr8 | 109321692 | - |
| intron-intron | ENST00000538769 | ENST00000220849 | PTK2 | chr8 | 142011224 | - | EIF3E | chr8 | 109321692 | - |
| intron-intron | ENST00000538769 | ENST00000519030 | PTK2 | chr8 | 142011224 | - | EIF3E | chr8 | 109321692 | - |
| intron-intron | ENST00000538769 | ENST00000519517 | PTK2 | chr8 | 142011224 | - | EIF3E | chr8 | 109321692 | - |
| 5UTR-intron | ENST00000340930 | ENST00000220849 | PTK2 | chr8 | 142011224 | - | EIF3E | chr8 | 109321692 | - |
| 5UTR-intron | ENST00000340930 | ENST00000519030 | PTK2 | chr8 | 142011224 | - | EIF3E | chr8 | 109321692 | - |
| 5UTR-intron | ENST00000340930 | ENST00000519517 | PTK2 | chr8 | 142011224 | - | EIF3E | chr8 | 109321692 | - |
| intron-intron | ENST00000519419 | ENST00000220849 | PTK2 | chr8 | 142011224 | - | EIF3E | chr8 | 109321692 | - |
| intron-intron | ENST00000519419 | ENST00000519030 | PTK2 | chr8 | 142011224 | - | EIF3E | chr8 | 109321692 | - |
| intron-intron | ENST00000519419 | ENST00000519517 | PTK2 | chr8 | 142011224 | - | EIF3E | chr8 | 109321692 | - |
| intron-intron | ENST00000430260 | ENST00000220849 | PTK2 | chr8 | 142011224 | - | EIF3E | chr8 | 109321692 | - |
| intron-intron | ENST00000430260 | ENST00000519030 | PTK2 | chr8 | 142011224 | - | EIF3E | chr8 | 109321692 | - |
| intron-intron | ENST00000430260 | ENST00000519517 | PTK2 | chr8 | 142011224 | - | EIF3E | chr8 | 109321692 | - |
| 5UTR-intron | ENST00000519881 | ENST00000220849 | PTK2 | chr8 | 142011224 | - | EIF3E | chr8 | 109321692 | - |
| 5UTR-intron | ENST00000519881 | ENST00000519030 | PTK2 | chr8 | 142011224 | - | EIF3E | chr8 | 109321692 | - |
| 5UTR-intron | ENST00000519881 | ENST00000519517 | PTK2 | chr8 | 142011224 | - | EIF3E | chr8 | 109321692 | - |
| intron-intron | ENST00000520892 | ENST00000220849 | PTK2 | chr8 | 142011224 | - | EIF3E | chr8 | 109321692 | - |
| intron-intron | ENST00000520892 | ENST00000519030 | PTK2 | chr8 | 142011224 | - | EIF3E | chr8 | 109321692 | - |
| intron-intron | ENST00000520892 | ENST00000519517 | PTK2 | chr8 | 142011224 | - | EIF3E | chr8 | 109321692 | - |
| intron-intron | ENST00000519635 | ENST00000220849 | PTK2 | chr8 | 142011224 | - | EIF3E | chr8 | 109321692 | - |
| intron-intron | ENST00000519635 | ENST00000519030 | PTK2 | chr8 | 142011224 | - | EIF3E | chr8 | 109321692 | - |
| intron-intron | ENST00000519635 | ENST00000519517 | PTK2 | chr8 | 142011224 | - | EIF3E | chr8 | 109321692 | - |
| intron-intron | ENST00000517712 | ENST00000220849 | PTK2 | chr8 | 142011224 | - | EIF3E | chr8 | 109321692 | - |
| intron-intron | ENST00000517712 | ENST00000519030 | PTK2 | chr8 | 142011224 | - | EIF3E | chr8 | 109321692 | - |
| intron-intron | ENST00000517712 | ENST00000519517 | PTK2 | chr8 | 142011224 | - | EIF3E | chr8 | 109321692 | - |
| intron-intron | ENST00000522950 | ENST00000220849 | PTK2 | chr8 | 142011224 | - | EIF3E | chr8 | 109321692 | - |
| intron-intron | ENST00000522950 | ENST00000519030 | PTK2 | chr8 | 142011224 | - | EIF3E | chr8 | 109321692 | - |
| intron-intron | ENST00000522950 | ENST00000519517 | PTK2 | chr8 | 142011224 | - | EIF3E | chr8 | 109321692 | - |
| intron-intron | ENST00000520151 | ENST00000220849 | PTK2 | chr8 | 142011224 | - | EIF3E | chr8 | 109321692 | - |
| intron-intron | ENST00000520151 | ENST00000519030 | PTK2 | chr8 | 142011224 | - | EIF3E | chr8 | 109321692 | - |
| intron-intron | ENST00000520151 | ENST00000519517 | PTK2 | chr8 | 142011224 | - | EIF3E | chr8 | 109321692 | - |
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FusionProtFeatures for PTK2_EIF3E |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PTK2 | EIF3E |