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Fusion gene ID: 29334

FusionGeneSummary for PTGS1_GNAS

Fusion gene summary

Fusion gene information	Fusion gene name: PTGS1_GNAS
	Fusion gene ID: 29334
		Hgene	Tgene
	Gene symbol	PTGS1	GNAS
	Gene ID	5742	2778
	Gene name	prostaglandin-endoperoxide synthase 1	GNAS complex locus
	Synonyms	COX1\|COX3\|PCOX1\|PES-1\|PGG/HS\|PGHS-1\|PGHS1\|PHS1\|PTGHS	AHO\|C20orf45\|GNAS1\|GPSA\|GSA\|GSP\|NESP\|PITA3\|POH\|SCG6\|SgVI
	Cytomap	9q33.2	20q13.32
	Type of gene	protein-coding	protein-coding
	Description	prostaglandin G/H synthase 1PGH synthase 1cyclooxygenase-1prostaglandin H2 synthase 1prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)	protein ALEXprotein GNASprotein SCG6 (secretogranin VI)G protein subunit alpha Sadenylate cyclase-stimulating G alpha proteinalternative gene product encoded by XL-exonextra large alphas proteinguanine nucleotide binding protein (G protein), alpha
	Modification date	20180519	20180523
	UniProtAcc	P23219	Q5JWF2
	Ensembl transtripts involved in fusion gene	ENST00000540753, ENST00000223423, ENST00000362012, ENST00000373698,	ENST00000313949, ENST00000371098, ENST00000371075, ENST00000371100, ENST00000371099, ENST00000371102, ENST00000464624, ENST00000306120, ENST00000371095, ENST00000371085, ENST00000354359, ENST00000265620, ENST00000306090, ENST00000371081,
Fusion gene scores	* DoF score	3 X 3 X 1=9	33 X 25 X 8=6600
	# samples	3	35
	** MAII score	log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(35/6600*10)=-4.23703919730085 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: PTGS1 [Title/Abstract] AND GNAS [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	PTGS1	GO:0019371	cyclooxygenase pathway	1380156

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			AA773408	PTGS1	chr9	125155344	+	GNAS	chr20	57470930	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-intron	ENST00000540753	ENST00000313949	PTGS1	chr9	125155344	+	GNAS	chr20	57470930	+
intron-intron	ENST00000540753	ENST00000371098	PTGS1	chr9	125155344	+	GNAS	chr20	57470930	+
intron-intron	ENST00000540753	ENST00000371075	PTGS1	chr9	125155344	+	GNAS	chr20	57470930	+
intron-intron	ENST00000540753	ENST00000371100	PTGS1	chr9	125155344	+	GNAS	chr20	57470930	+
intron-intron	ENST00000540753	ENST00000371099	PTGS1	chr9	125155344	+	GNAS	chr20	57470930	+
intron-intron	ENST00000540753	ENST00000371102	PTGS1	chr9	125155344	+	GNAS	chr20	57470930	+
intron-intron	ENST00000540753	ENST00000464624	PTGS1	chr9	125155344	+	GNAS	chr20	57470930	+
intron-intron	ENST00000540753	ENST00000306120	PTGS1	chr9	125155344	+	GNAS	chr20	57470930	+
intron-intron	ENST00000540753	ENST00000371095	PTGS1	chr9	125155344	+	GNAS	chr20	57470930	+
intron-intron	ENST00000540753	ENST00000371085	PTGS1	chr9	125155344	+	GNAS	chr20	57470930	+
intron-intron	ENST00000540753	ENST00000354359	PTGS1	chr9	125155344	+	GNAS	chr20	57470930	+
intron-intron	ENST00000540753	ENST00000265620	PTGS1	chr9	125155344	+	GNAS	chr20	57470930	+
intron-intron	ENST00000540753	ENST00000306090	PTGS1	chr9	125155344	+	GNAS	chr20	57470930	+
intron-intron	ENST00000540753	ENST00000371081	PTGS1	chr9	125155344	+	GNAS	chr20	57470930	+
3UTR-intron	ENST00000223423	ENST00000313949	PTGS1	chr9	125155344	+	GNAS	chr20	57470930	+
3UTR-intron	ENST00000223423	ENST00000371098	PTGS1	chr9	125155344	+	GNAS	chr20	57470930	+
3UTR-intron	ENST00000223423	ENST00000371075	PTGS1	chr9	125155344	+	GNAS	chr20	57470930	+
3UTR-intron	ENST00000223423	ENST00000371100	PTGS1	chr9	125155344	+	GNAS	chr20	57470930	+
3UTR-intron	ENST00000223423	ENST00000371099	PTGS1	chr9	125155344	+	GNAS	chr20	57470930	+
3UTR-intron	ENST00000223423	ENST00000371102	PTGS1	chr9	125155344	+	GNAS	chr20	57470930	+
3UTR-intron	ENST00000223423	ENST00000464624	PTGS1	chr9	125155344	+	GNAS	chr20	57470930	+
3UTR-intron	ENST00000223423	ENST00000306120	PTGS1	chr9	125155344	+	GNAS	chr20	57470930	+
3UTR-intron	ENST00000223423	ENST00000371095	PTGS1	chr9	125155344	+	GNAS	chr20	57470930	+
3UTR-intron	ENST00000223423	ENST00000371085	PTGS1	chr9	125155344	+	GNAS	chr20	57470930	+
3UTR-intron	ENST00000223423	ENST00000354359	PTGS1	chr9	125155344	+	GNAS	chr20	57470930	+
3UTR-intron	ENST00000223423	ENST00000265620	PTGS1	chr9	125155344	+	GNAS	chr20	57470930	+
3UTR-intron	ENST00000223423	ENST00000306090	PTGS1	chr9	125155344	+	GNAS	chr20	57470930	+
3UTR-intron	ENST00000223423	ENST00000371081	PTGS1	chr9	125155344	+	GNAS	chr20	57470930	+
3UTR-intron	ENST00000362012	ENST00000313949	PTGS1	chr9	125155344	+	GNAS	chr20	57470930	+
3UTR-intron	ENST00000362012	ENST00000371098	PTGS1	chr9	125155344	+	GNAS	chr20	57470930	+
3UTR-intron	ENST00000362012	ENST00000371075	PTGS1	chr9	125155344	+	GNAS	chr20	57470930	+
3UTR-intron	ENST00000362012	ENST00000371100	PTGS1	chr9	125155344	+	GNAS	chr20	57470930	+
3UTR-intron	ENST00000362012	ENST00000371099	PTGS1	chr9	125155344	+	GNAS	chr20	57470930	+
3UTR-intron	ENST00000362012	ENST00000371102	PTGS1	chr9	125155344	+	GNAS	chr20	57470930	+
3UTR-intron	ENST00000362012	ENST00000464624	PTGS1	chr9	125155344	+	GNAS	chr20	57470930	+
3UTR-intron	ENST00000362012	ENST00000306120	PTGS1	chr9	125155344	+	GNAS	chr20	57470930	+
3UTR-intron	ENST00000362012	ENST00000371095	PTGS1	chr9	125155344	+	GNAS	chr20	57470930	+
3UTR-intron	ENST00000362012	ENST00000371085	PTGS1	chr9	125155344	+	GNAS	chr20	57470930	+
3UTR-intron	ENST00000362012	ENST00000354359	PTGS1	chr9	125155344	+	GNAS	chr20	57470930	+
3UTR-intron	ENST00000362012	ENST00000265620	PTGS1	chr9	125155344	+	GNAS	chr20	57470930	+
3UTR-intron	ENST00000362012	ENST00000306090	PTGS1	chr9	125155344	+	GNAS	chr20	57470930	+
3UTR-intron	ENST00000362012	ENST00000371081	PTGS1	chr9	125155344	+	GNAS	chr20	57470930	+
intron-intron	ENST00000373698	ENST00000313949	PTGS1	chr9	125155344	+	GNAS	chr20	57470930	+
intron-intron	ENST00000373698	ENST00000371098	PTGS1	chr9	125155344	+	GNAS	chr20	57470930	+
intron-intron	ENST00000373698	ENST00000371075	PTGS1	chr9	125155344	+	GNAS	chr20	57470930	+
intron-intron	ENST00000373698	ENST00000371100	PTGS1	chr9	125155344	+	GNAS	chr20	57470930	+
intron-intron	ENST00000373698	ENST00000371099	PTGS1	chr9	125155344	+	GNAS	chr20	57470930	+
intron-intron	ENST00000373698	ENST00000371102	PTGS1	chr9	125155344	+	GNAS	chr20	57470930	+
intron-intron	ENST00000373698	ENST00000464624	PTGS1	chr9	125155344	+	GNAS	chr20	57470930	+
intron-intron	ENST00000373698	ENST00000306120	PTGS1	chr9	125155344	+	GNAS	chr20	57470930	+
intron-intron	ENST00000373698	ENST00000371095	PTGS1	chr9	125155344	+	GNAS	chr20	57470930	+
intron-intron	ENST00000373698	ENST00000371085	PTGS1	chr9	125155344	+	GNAS	chr20	57470930	+
intron-intron	ENST00000373698	ENST00000354359	PTGS1	chr9	125155344	+	GNAS	chr20	57470930	+
intron-intron	ENST00000373698	ENST00000265620	PTGS1	chr9	125155344	+	GNAS	chr20	57470930	+
intron-intron	ENST00000373698	ENST00000306090	PTGS1	chr9	125155344	+	GNAS	chr20	57470930	+
intron-intron	ENST00000373698	ENST00000371081	PTGS1	chr9	125155344	+	GNAS	chr20	57470930	+

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FusionProtFeatures for PTGS1_GNAS

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
PTGS1 P23219	GNAS Q5JWF2

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Fusion gene ID: 29334

FusionGeneSummary for PTGS1_GNAS

FusionProtFeatures for PTGS1_GNAS