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Fusion gene ID: 29328 |
FusionGeneSummary for PTGFRN_NOTCH2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PTGFRN_NOTCH2 | Fusion gene ID: 29328 | Hgene | Tgene | Gene symbol | PTGFRN | NOTCH2 | Gene ID | 5738 | 4853 |
| Gene name | prostaglandin F2 receptor inhibitor | notch 2 | |
| Synonyms | CD315|CD9P-1|EWI-F|FPRP|SMAP-6 | AGS2|HJCYS|hN2 | |
| Cytomap | 1p13.1 | 1p12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | prostaglandin F2 receptor negative regulatorCD9 partner 1glu-Trp-Ile EWI motif-containing protein Fprostaglandin F2-alpha receptor regulatory proteinprostaglandin F2-alpha receptor-associated protein | neurogenic locus notch homolog protein 2Notch homolog 2 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q9P2B2 | Q04721 | |
| Ensembl transtripts involved in fusion gene | ENST00000393203, ENST00000496699, | ENST00000256646, ENST00000602566, ENST00000493703, | |
| Fusion gene scores | * DoF score | 4 X 3 X 3=36 | 9 X 7 X 3=189 |
| # samples | 4 | 9 | |
| ** MAII score | log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(9/189*10)=-1.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: PTGFRN [Title/Abstract] AND NOTCH2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | NOTCH2 | GO:0007050 | cell cycle arrest | 11306509 |
| Tgene | NOTCH2 | GO:0007219 | Notch signaling pathway | 11306509|25985737 |
| Tgene | NOTCH2 | GO:0010629 | negative regulation of gene expression | 11306509 |
| Tgene | NOTCH2 | GO:0045967 | negative regulation of growth rate | 11306509 |
| Tgene | NOTCH2 | GO:0046579 | positive regulation of Ras protein signal transduction | 11306509 |
| Tgene | NOTCH2 | GO:0070374 | positive regulation of ERK1 and ERK2 cascade | 11306509 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-C8-A12L-01A | PTGFRN | chr1 | 117492194 | + | NOTCH2 | chr1 | 120512367 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000393203 | ENST00000256646 | PTGFRN | chr1 | 117492194 | + | NOTCH2 | chr1 | 120512367 | - |
| 5CDS-intron | ENST00000393203 | ENST00000602566 | PTGFRN | chr1 | 117492194 | + | NOTCH2 | chr1 | 120512367 | - |
| 5CDS-intron | ENST00000393203 | ENST00000493703 | PTGFRN | chr1 | 117492194 | + | NOTCH2 | chr1 | 120512367 | - |
| intron-3CDS | ENST00000496699 | ENST00000256646 | PTGFRN | chr1 | 117492194 | + | NOTCH2 | chr1 | 120512367 | - |
| intron-intron | ENST00000496699 | ENST00000602566 | PTGFRN | chr1 | 117492194 | + | NOTCH2 | chr1 | 120512367 | - |
| intron-intron | ENST00000496699 | ENST00000493703 | PTGFRN | chr1 | 117492194 | + | NOTCH2 | chr1 | 120512367 | - |
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FusionProtFeatures for PTGFRN_NOTCH2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PTGFRN | NOTCH2 |