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Fusion gene ID: 29233 |
FusionGeneSummary for PSMG2_PTPN2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PSMG2_PTPN2 | Fusion gene ID: 29233 | Hgene | Tgene | Gene symbol | PSMG2 | PTPN2 | Gene ID | 56984 | 5771 |
| Gene name | proteasome assembly chaperone 2 | protein tyrosine phosphatase, non-receptor type 2 | |
| Synonyms | CLAST3|HCCA3|HsT1707|MDS003|PAC2|TNFSF5IP1 | PTN2|PTPT|TC-PTP|TCELLPTP|TCPTP | |
| Cytomap | 18p11.21 | 18p11.21 | |
| Type of gene | protein-coding | protein-coding | |
| Description | proteasome assembly chaperone 2CD40 ligand-activated specific transcript 3HDCMC29PHSPC260PAC-2hepatocellular carcinoma susceptibility proteinhepatocellular carcinoma-susceptibility protein 3likely ortholog of mouse CD40 ligand-activated specific tr | tyrosine-protein phosphatase non-receptor type 2T-cell protein tyrosine phosphatase | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q969U7 | P17706 | |
| Ensembl transtripts involved in fusion gene | ENST00000585331, ENST00000317615, ENST00000590217, ENST00000589405, | ENST00000327283, ENST00000591115, ENST00000353319, ENST00000309660, ENST00000589086, ENST00000591497, | |
| Fusion gene scores | * DoF score | 5 X 5 X 4=100 | 3 X 3 X 3=27 |
| # samples | 5 | 3 | |
| ** MAII score | log2(5/100*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: PSMG2 [Title/Abstract] AND PTPN2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | PSMG2 | GO:0043248 | proteasome assembly | 16251969 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LUSC | TCGA-68-8251-01A | PSMG2 | chr18 | 12724618 | + | PTPN2 | chr18 | 12825943 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000585331 | ENST00000327283 | PSMG2 | chr18 | 12724618 | + | PTPN2 | chr18 | 12825943 | - |
| In-frame | ENST00000585331 | ENST00000591115 | PSMG2 | chr18 | 12724618 | + | PTPN2 | chr18 | 12825943 | - |
| In-frame | ENST00000585331 | ENST00000353319 | PSMG2 | chr18 | 12724618 | + | PTPN2 | chr18 | 12825943 | - |
| In-frame | ENST00000585331 | ENST00000309660 | PSMG2 | chr18 | 12724618 | + | PTPN2 | chr18 | 12825943 | - |
| 5CDS-intron | ENST00000585331 | ENST00000589086 | PSMG2 | chr18 | 12724618 | + | PTPN2 | chr18 | 12825943 | - |
| 5CDS-intron | ENST00000585331 | ENST00000591497 | PSMG2 | chr18 | 12724618 | + | PTPN2 | chr18 | 12825943 | - |
| In-frame | ENST00000317615 | ENST00000327283 | PSMG2 | chr18 | 12724618 | + | PTPN2 | chr18 | 12825943 | - |
| In-frame | ENST00000317615 | ENST00000591115 | PSMG2 | chr18 | 12724618 | + | PTPN2 | chr18 | 12825943 | - |
| In-frame | ENST00000317615 | ENST00000353319 | PSMG2 | chr18 | 12724618 | + | PTPN2 | chr18 | 12825943 | - |
| In-frame | ENST00000317615 | ENST00000309660 | PSMG2 | chr18 | 12724618 | + | PTPN2 | chr18 | 12825943 | - |
| 5CDS-intron | ENST00000317615 | ENST00000589086 | PSMG2 | chr18 | 12724618 | + | PTPN2 | chr18 | 12825943 | - |
| 5CDS-intron | ENST00000317615 | ENST00000591497 | PSMG2 | chr18 | 12724618 | + | PTPN2 | chr18 | 12825943 | - |
| In-frame | ENST00000590217 | ENST00000327283 | PSMG2 | chr18 | 12724618 | + | PTPN2 | chr18 | 12825943 | - |
| In-frame | ENST00000590217 | ENST00000591115 | PSMG2 | chr18 | 12724618 | + | PTPN2 | chr18 | 12825943 | - |
| In-frame | ENST00000590217 | ENST00000353319 | PSMG2 | chr18 | 12724618 | + | PTPN2 | chr18 | 12825943 | - |
| In-frame | ENST00000590217 | ENST00000309660 | PSMG2 | chr18 | 12724618 | + | PTPN2 | chr18 | 12825943 | - |
| 5CDS-intron | ENST00000590217 | ENST00000589086 | PSMG2 | chr18 | 12724618 | + | PTPN2 | chr18 | 12825943 | - |
| 5CDS-intron | ENST00000590217 | ENST00000591497 | PSMG2 | chr18 | 12724618 | + | PTPN2 | chr18 | 12825943 | - |
| intron-3CDS | ENST00000589405 | ENST00000327283 | PSMG2 | chr18 | 12724618 | + | PTPN2 | chr18 | 12825943 | - |
| intron-3CDS | ENST00000589405 | ENST00000591115 | PSMG2 | chr18 | 12724618 | + | PTPN2 | chr18 | 12825943 | - |
| intron-3CDS | ENST00000589405 | ENST00000353319 | PSMG2 | chr18 | 12724618 | + | PTPN2 | chr18 | 12825943 | - |
| intron-3CDS | ENST00000589405 | ENST00000309660 | PSMG2 | chr18 | 12724618 | + | PTPN2 | chr18 | 12825943 | - |
| intron-intron | ENST00000589405 | ENST00000589086 | PSMG2 | chr18 | 12724618 | + | PTPN2 | chr18 | 12825943 | - |
| intron-intron | ENST00000589405 | ENST00000591497 | PSMG2 | chr18 | 12724618 | + | PTPN2 | chr18 | 12825943 | - |
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FusionProtFeatures for PSMG2_PTPN2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PSMG2 | PTPN2 |