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Fusion gene ID: 29217 |
FusionGeneSummary for PSME2_ANKRD46 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PSME2_ANKRD46 | Fusion gene ID: 29217 | Hgene | Tgene | Gene symbol | PSME2 | ANKRD46 | Gene ID | 5721 | 157567 |
| Gene name | proteasome activator subunit 2 | ankyrin repeat domain 46 | |
| Synonyms | PA28B|PA28beta|REGbeta | ANK-S|GENX-115279 | |
| Cytomap | 14q12 | 8q22.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | proteasome activator complex subunit 211S regulator complex beta subunit11S regulator complex subunit betaMCP activator, 31-kD subunitREG-betaactivator of multicatalytic protease subunit 2cell migration-inducing protein 22proteasome (prosome, macro | ankyrin repeat domain-containing protein 46ankyrin repeat small protein | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q9UL46 | Q86W74 | |
| Ensembl transtripts involved in fusion gene | ENST00000560410, ENST00000216802, ENST00000471700, | ENST00000520552, ENST00000335659, ENST00000519597, ENST00000520311, ENST00000519316, ENST00000524319, | |
| Fusion gene scores | * DoF score | 4 X 4 X 1=16 | 5 X 4 X 6=120 |
| # samples | 7 | 10 | |
| ** MAII score | log2(7/16*10)=2.12928301694497 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(10/120*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: PSME2 [Title/Abstract] AND ANKRD46 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AV646791 | PSME2 | chr14 | 24614462 | - | ANKRD46 | chr8 | 101534921 | - | ||
| ChiTaRS3.1 | AV651403 | PSME2 | chr14 | 24614462 | - | ANKRD46 | chr8 | 101534921 | - | ||
| ChiTaRS3.1 | AV652105 | PSME2 | chr14 | 24614462 | - | ANKRD46 | chr8 | 101534921 | - | ||
| ChiTaRS3.1 | AV651374 | PSME2 | chr14 | 24614462 | - | ANKRD46 | chr8 | 101534921 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000560410 | ENST00000520552 | PSME2 | chr14 | 24614462 | - | ANKRD46 | chr8 | 101534921 | - |
| intron-3CDS | ENST00000560410 | ENST00000335659 | PSME2 | chr14 | 24614462 | - | ANKRD46 | chr8 | 101534921 | - |
| intron-3CDS | ENST00000560410 | ENST00000519597 | PSME2 | chr14 | 24614462 | - | ANKRD46 | chr8 | 101534921 | - |
| intron-3CDS | ENST00000560410 | ENST00000520311 | PSME2 | chr14 | 24614462 | - | ANKRD46 | chr8 | 101534921 | - |
| intron-3CDS | ENST00000560410 | ENST00000519316 | PSME2 | chr14 | 24614462 | - | ANKRD46 | chr8 | 101534921 | - |
| intron-intron | ENST00000560410 | ENST00000524319 | PSME2 | chr14 | 24614462 | - | ANKRD46 | chr8 | 101534921 | - |
| intron-3CDS | ENST00000216802 | ENST00000520552 | PSME2 | chr14 | 24614462 | - | ANKRD46 | chr8 | 101534921 | - |
| intron-3CDS | ENST00000216802 | ENST00000335659 | PSME2 | chr14 | 24614462 | - | ANKRD46 | chr8 | 101534921 | - |
| intron-3CDS | ENST00000216802 | ENST00000519597 | PSME2 | chr14 | 24614462 | - | ANKRD46 | chr8 | 101534921 | - |
| intron-3CDS | ENST00000216802 | ENST00000520311 | PSME2 | chr14 | 24614462 | - | ANKRD46 | chr8 | 101534921 | - |
| intron-3CDS | ENST00000216802 | ENST00000519316 | PSME2 | chr14 | 24614462 | - | ANKRD46 | chr8 | 101534921 | - |
| intron-intron | ENST00000216802 | ENST00000524319 | PSME2 | chr14 | 24614462 | - | ANKRD46 | chr8 | 101534921 | - |
| intron-3CDS | ENST00000471700 | ENST00000520552 | PSME2 | chr14 | 24614462 | - | ANKRD46 | chr8 | 101534921 | - |
| intron-3CDS | ENST00000471700 | ENST00000335659 | PSME2 | chr14 | 24614462 | - | ANKRD46 | chr8 | 101534921 | - |
| intron-3CDS | ENST00000471700 | ENST00000519597 | PSME2 | chr14 | 24614462 | - | ANKRD46 | chr8 | 101534921 | - |
| intron-3CDS | ENST00000471700 | ENST00000520311 | PSME2 | chr14 | 24614462 | - | ANKRD46 | chr8 | 101534921 | - |
| intron-3CDS | ENST00000471700 | ENST00000519316 | PSME2 | chr14 | 24614462 | - | ANKRD46 | chr8 | 101534921 | - |
| intron-intron | ENST00000471700 | ENST00000524319 | PSME2 | chr14 | 24614462 | - | ANKRD46 | chr8 | 101534921 | - |
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FusionProtFeatures for PSME2_ANKRD46 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PSME2 | ANKRD46 |