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Fusion gene ID: 29159

FusionGeneSummary for PSMC5_PSD3

Fusion gene summary

Fusion gene information	Fusion gene name: PSMC5_PSD3
	Fusion gene ID: 29159
		Hgene	Tgene
	Gene symbol	PSMC5	PSD3
	Gene ID	5705	23362
	Gene name	proteasome 26S subunit, ATPase 5	pleckstrin and Sec7 domain containing 3
	Synonyms	S8\|SUG-1\|SUG1\|TBP10\|TRIP1\|p45\|p45/SUG	EFA6D\|EFA6R\|HCA67
	Cytomap	17q23.3	8p22
	Type of gene	protein-coding	protein-coding
	Description	26S proteasome regulatory subunit 826S protease regulatory subunit 826S proteasome AAA-ATPase subunit RPT6MSUG1 proteinTat-binding protein homolog 10proteasome (prosome, macropain) 26S subunit, ATPase, 5proteasome 26S ATPase subunit 5proteasome sub	PH and SEC7 domain-containing protein 3ADP-ribosylation factor guanine nucleotide factor 6epididymis tissue protein Li 20mPexchange factor for ADP-ribosylation factor guanine nucleotide factor 6exchange factor for ADP-ribosylation factor guanine nucle
	Modification date	20180523	20180523
	UniProtAcc	P62195	Q9NYI0
	Ensembl transtripts involved in fusion gene	ENST00000310144, ENST00000582420, ENST00000580864, ENST00000375812, ENST00000581882,	ENST00000327040, ENST00000440756, ENST00000286485, ENST00000428502, ENST00000523619, ENST00000520789,
Fusion gene scores	* DoF score	7 X 8 X 1=56	4 X 4 X 2=32
	# samples	8	4
	** MAII score	log2(8/56*10)=0.514573172829758 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: PSMC5 [Title/Abstract] AND PSD3 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	PSMC5	GO:0006357	regulation of transcription by RNA polymerase II	7870181
Hgene	PSMC5	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	12110588

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			CK725100	PSMC5	chr17	61909127	-	PSD3	chr8	18725438	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
Frame-shift	ENST00000310144	ENST00000327040	PSMC5	chr17	61909127	-	PSD3	chr8	18725438	+
Frame-shift	ENST00000310144	ENST00000440756	PSMC5	chr17	61909127	-	PSD3	chr8	18725438	+
5CDS-intron	ENST00000310144	ENST00000286485	PSMC5	chr17	61909127	-	PSD3	chr8	18725438	+
5CDS-intron	ENST00000310144	ENST00000428502	PSMC5	chr17	61909127	-	PSD3	chr8	18725438	+
5CDS-intron	ENST00000310144	ENST00000523619	PSMC5	chr17	61909127	-	PSD3	chr8	18725438	+
5CDS-intron	ENST00000310144	ENST00000520789	PSMC5	chr17	61909127	-	PSD3	chr8	18725438	+
intron-3CDS	ENST00000582420	ENST00000327040	PSMC5	chr17	61909127	-	PSD3	chr8	18725438	+
intron-3CDS	ENST00000582420	ENST00000440756	PSMC5	chr17	61909127	-	PSD3	chr8	18725438	+
intron-intron	ENST00000582420	ENST00000286485	PSMC5	chr17	61909127	-	PSD3	chr8	18725438	+
intron-intron	ENST00000582420	ENST00000428502	PSMC5	chr17	61909127	-	PSD3	chr8	18725438	+
intron-intron	ENST00000582420	ENST00000523619	PSMC5	chr17	61909127	-	PSD3	chr8	18725438	+
intron-intron	ENST00000582420	ENST00000520789	PSMC5	chr17	61909127	-	PSD3	chr8	18725438	+
Frame-shift	ENST00000580864	ENST00000327040	PSMC5	chr17	61909127	-	PSD3	chr8	18725438	+
Frame-shift	ENST00000580864	ENST00000440756	PSMC5	chr17	61909127	-	PSD3	chr8	18725438	+
5CDS-intron	ENST00000580864	ENST00000286485	PSMC5	chr17	61909127	-	PSD3	chr8	18725438	+
5CDS-intron	ENST00000580864	ENST00000428502	PSMC5	chr17	61909127	-	PSD3	chr8	18725438	+
5CDS-intron	ENST00000580864	ENST00000523619	PSMC5	chr17	61909127	-	PSD3	chr8	18725438	+
5CDS-intron	ENST00000580864	ENST00000520789	PSMC5	chr17	61909127	-	PSD3	chr8	18725438	+
Frame-shift	ENST00000375812	ENST00000327040	PSMC5	chr17	61909127	-	PSD3	chr8	18725438	+
Frame-shift	ENST00000375812	ENST00000440756	PSMC5	chr17	61909127	-	PSD3	chr8	18725438	+
5CDS-intron	ENST00000375812	ENST00000286485	PSMC5	chr17	61909127	-	PSD3	chr8	18725438	+
5CDS-intron	ENST00000375812	ENST00000428502	PSMC5	chr17	61909127	-	PSD3	chr8	18725438	+
5CDS-intron	ENST00000375812	ENST00000523619	PSMC5	chr17	61909127	-	PSD3	chr8	18725438	+
5CDS-intron	ENST00000375812	ENST00000520789	PSMC5	chr17	61909127	-	PSD3	chr8	18725438	+
Frame-shift	ENST00000581882	ENST00000327040	PSMC5	chr17	61909127	-	PSD3	chr8	18725438	+
Frame-shift	ENST00000581882	ENST00000440756	PSMC5	chr17	61909127	-	PSD3	chr8	18725438	+
5CDS-intron	ENST00000581882	ENST00000286485	PSMC5	chr17	61909127	-	PSD3	chr8	18725438	+
5CDS-intron	ENST00000581882	ENST00000428502	PSMC5	chr17	61909127	-	PSD3	chr8	18725438	+
5CDS-intron	ENST00000581882	ENST00000523619	PSMC5	chr17	61909127	-	PSD3	chr8	18725438	+
5CDS-intron	ENST00000581882	ENST00000520789	PSMC5	chr17	61909127	-	PSD3	chr8	18725438	+

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FusionProtFeatures for PSMC5_PSD3

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
PSMC5 P62195	PSD3 Q9NYI0

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Fusion gene ID: 29159

FusionGeneSummary for PSMC5_PSD3

FusionProtFeatures for PSMC5_PSD3