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Fusion gene ID: 29022 |
FusionGeneSummary for PRUNE2_ACTC1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PRUNE2_ACTC1 | Fusion gene ID: 29022 | Hgene | Tgene | Gene symbol | PRUNE2 | ACTC1 | Gene ID | 158471 | 70 |
| Gene name | prune homolog 2 | actin, alpha, cardiac muscle 1 | |
| Synonyms | BMCC1|BNIPXL|C9orf65|KIAA0367 | ACTC|ASD5|CMD1R|CMH11|LVNC4 | |
| Cytomap | 9q21.2 | 15q14 | |
| Type of gene | protein-coding | protein-coding | |
| Description | protein prune homolog 2BCH motif-containing molecule at the carboxyl terminal region 1BNIP2 motif containing molecule at the carboxyl terminal region 1BNIP2 motif-containing molecule at the C-terminal region 1olfaxintruncated PRUNE2 | actin, alpha cardiac muscle 1 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q8WUY3 | P68032 | |
| Ensembl transtripts involved in fusion gene | ENST00000466266, ENST00000428286, ENST00000376718, ENST00000443509, ENST00000223609, ENST00000376713, | ENST00000290378, ENST00000557860, | |
| Fusion gene scores | * DoF score | 6 X 5 X 5=150 | 2 X 2 X 2=8 |
| # samples | 7 | 3 | |
| ** MAII score | log2(7/150*10)=-1.09953567355091 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/8*10)=1.90689059560852 | |
| Context | PubMed: PRUNE2 [Title/Abstract] AND ACTC1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | ACTC1 | GO:0030048 | actin filament-based movement | 16611632 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AW962398 | PRUNE2 | chr9 | 79229480 | - | ACTC1 | chr15 | 35082704 | - | ||
| ChiTaRS3.1 | AA328550 | PRUNE2 | chr9 | 79229480 | - | ACTC1 | chr15 | 35082704 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000466266 | ENST00000290378 | PRUNE2 | chr9 | 79229480 | - | ACTC1 | chr15 | 35082704 | - |
| intron-intron | ENST00000466266 | ENST00000557860 | PRUNE2 | chr9 | 79229480 | - | ACTC1 | chr15 | 35082704 | - |
| intron-3CDS | ENST00000428286 | ENST00000290378 | PRUNE2 | chr9 | 79229480 | - | ACTC1 | chr15 | 35082704 | - |
| intron-intron | ENST00000428286 | ENST00000557860 | PRUNE2 | chr9 | 79229480 | - | ACTC1 | chr15 | 35082704 | - |
| intron-3CDS | ENST00000376718 | ENST00000290378 | PRUNE2 | chr9 | 79229480 | - | ACTC1 | chr15 | 35082704 | - |
| intron-intron | ENST00000376718 | ENST00000557860 | PRUNE2 | chr9 | 79229480 | - | ACTC1 | chr15 | 35082704 | - |
| intron-3CDS | ENST00000443509 | ENST00000290378 | PRUNE2 | chr9 | 79229480 | - | ACTC1 | chr15 | 35082704 | - |
| intron-intron | ENST00000443509 | ENST00000557860 | PRUNE2 | chr9 | 79229480 | - | ACTC1 | chr15 | 35082704 | - |
| intron-3CDS | ENST00000223609 | ENST00000290378 | PRUNE2 | chr9 | 79229480 | - | ACTC1 | chr15 | 35082704 | - |
| intron-intron | ENST00000223609 | ENST00000557860 | PRUNE2 | chr9 | 79229480 | - | ACTC1 | chr15 | 35082704 | - |
| intron-3CDS | ENST00000376713 | ENST00000290378 | PRUNE2 | chr9 | 79229480 | - | ACTC1 | chr15 | 35082704 | - |
| intron-intron | ENST00000376713 | ENST00000557860 | PRUNE2 | chr9 | 79229480 | - | ACTC1 | chr15 | 35082704 | - |
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FusionProtFeatures for PRUNE2_ACTC1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PRUNE2 | ACTC1 |