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Fusion gene ID: 29001 |
FusionGeneSummary for PRRG4_RAPGEFL1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PRRG4_RAPGEFL1 | Fusion gene ID: 29001 | Hgene | Tgene | Gene symbol | PRRG4 | RAPGEFL1 | Gene ID | 79056 | 51195 |
| Gene name | proline rich and Gla domain 4 | Rap guanine nucleotide exchange factor like 1 | |
| Synonyms | PRGP4|TMG4 | Link-GEFII | |
| Cytomap | 11p13 | 17q21.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | transmembrane gamma-carboxyglutamic acid protein 4proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)proline rich Gla 4 (transmembrane) isoform 1proline rich Gla 4 (transmembrane) isoform 2proline rich Gla 4 (transmembrane) isoform 3proline-r | rap guanine nucleotide exchange factor-like 1Link guanine nucleotide exchange factor IIRap guanine nucleotide exchange factor (GEF)-like 1link GEFII | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | Q9BZD6 | Q9UHV5 | |
| Ensembl transtripts involved in fusion gene | ENST00000257836, | ENST00000456989, ENST00000544503, ENST00000264644, ENST00000540388, ENST00000436615, | |
| Fusion gene scores | * DoF score | 4 X 2 X 4=32 | 2 X 2 X 2=8 |
| # samples | 4 | 2 | |
| ** MAII score | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: PRRG4 [Title/Abstract] AND RAPGEFL1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-B6-A0IG-01A | PRRG4 | chr11 | 32852178 | + | RAPGEFL1 | chr17 | 38345118 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000257836 | ENST00000456989 | PRRG4 | chr11 | 32852178 | + | RAPGEFL1 | chr17 | 38345118 | + |
| Frame-shift | ENST00000257836 | ENST00000544503 | PRRG4 | chr11 | 32852178 | + | RAPGEFL1 | chr17 | 38345118 | + |
| Frame-shift | ENST00000257836 | ENST00000264644 | PRRG4 | chr11 | 32852178 | + | RAPGEFL1 | chr17 | 38345118 | + |
| 5CDS-3UTR | ENST00000257836 | ENST00000540388 | PRRG4 | chr11 | 32852178 | + | RAPGEFL1 | chr17 | 38345118 | + |
| 5CDS-3UTR | ENST00000257836 | ENST00000436615 | PRRG4 | chr11 | 32852178 | + | RAPGEFL1 | chr17 | 38345118 | + |
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FusionProtFeatures for PRRG4_RAPGEFL1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PRRG4 | RAPGEFL1 |