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Fusion gene ID: 28907 |
FusionGeneSummary for PRPSAP2_PLLP |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PRPSAP2_PLLP | Fusion gene ID: 28907 | Hgene | Tgene | Gene symbol | PRPSAP2 | PLLP | Gene ID | 5636 | 51090 |
| Gene name | phosphoribosyl pyrophosphate synthetase associated protein 2 | plasmolipin | |
| Synonyms | PAP41 | PMLP|TM4SF11 | |
| Cytomap | 17p11.2 | 16q13 | |
| Type of gene | protein-coding | protein-coding | |
| Description | phosphoribosyl pyrophosphate synthase-associated protein 241 kDa phosphoribosypyrophosphate synthetase-associated proteinPRPP synthase-associated protein 2 | plasmolipinplasma membrane proteolipid (plasmolipin)transmembrane 4 superfamily member 11 (plasmolipin) | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | O60256 | Q9Y342 | |
| Ensembl transtripts involved in fusion gene | ENST00000419071, ENST00000268835, ENST00000536323, ENST00000542013, ENST00000575337, | ENST00000219207, ENST00000569059, | |
| Fusion gene scores | * DoF score | 6 X 6 X 5=180 | 3 X 2 X 3=18 |
| # samples | 7 | 3 | |
| ** MAII score | log2(7/180*10)=-1.36257007938471 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: PRPSAP2 [Title/Abstract] AND PLLP [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | HNSC | TCGA-BA-A8YP-01A | PRPSAP2 | chr17 | 18770647 | + | PLLP | chr16 | 57292496 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000419071 | ENST00000219207 | PRPSAP2 | chr17 | 18770647 | + | PLLP | chr16 | 57292496 | - |
| intron-3CDS | ENST00000419071 | ENST00000569059 | PRPSAP2 | chr17 | 18770647 | + | PLLP | chr16 | 57292496 | - |
| Frame-shift | ENST00000268835 | ENST00000219207 | PRPSAP2 | chr17 | 18770647 | + | PLLP | chr16 | 57292496 | - |
| Frame-shift | ENST00000268835 | ENST00000569059 | PRPSAP2 | chr17 | 18770647 | + | PLLP | chr16 | 57292496 | - |
| intron-3CDS | ENST00000536323 | ENST00000219207 | PRPSAP2 | chr17 | 18770647 | + | PLLP | chr16 | 57292496 | - |
| intron-3CDS | ENST00000536323 | ENST00000569059 | PRPSAP2 | chr17 | 18770647 | + | PLLP | chr16 | 57292496 | - |
| Frame-shift | ENST00000542013 | ENST00000219207 | PRPSAP2 | chr17 | 18770647 | + | PLLP | chr16 | 57292496 | - |
| Frame-shift | ENST00000542013 | ENST00000569059 | PRPSAP2 | chr17 | 18770647 | + | PLLP | chr16 | 57292496 | - |
| intron-3CDS | ENST00000575337 | ENST00000219207 | PRPSAP2 | chr17 | 18770647 | + | PLLP | chr16 | 57292496 | - |
| intron-3CDS | ENST00000575337 | ENST00000569059 | PRPSAP2 | chr17 | 18770647 | + | PLLP | chr16 | 57292496 | - |
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FusionProtFeatures for PRPSAP2_PLLP |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PRPSAP2 | PLLP |