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Fusion gene ID: 2890 |
FusionGeneSummary for ASAP1_ADCY2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ASAP1_ADCY2 | Fusion gene ID: 2890 | Hgene | Tgene | Gene symbol | ASAP1 | ADCY2 | Gene ID | 50807 | 108 |
| Gene name | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | adenylate cyclase 2 | |
| Synonyms | AMAP1|CENTB4|DDEF1|PAG2|PAP|ZG14P | AC2|HBAC2 | |
| Cytomap | 8q24.21-q24.22 | 5p15.31 | |
| Type of gene | protein-coding | protein-coding | |
| Description | arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase-activating protein130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating proteinADP-ribosyl | adenylate cyclase type 23',5'-cyclic AMP synthetaseATP pyrophosphate-lyase 2adenylate cyclase 2 (brain)adenylate cyclase IIadenylate cyclase type IIadenylyl cyclase 2type II adenylate cyclase | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | Q9ULH1 | Q08462 | |
| Ensembl transtripts involved in fusion gene | ENST00000357668, ENST00000518721, ENST00000520625, | ENST00000338316, ENST00000537121, ENST00000513693, | |
| Fusion gene scores | * DoF score | 20 X 11 X 10=2200 | 13 X 12 X 5=780 |
| # samples | 22 | 13 | |
| ** MAII score | log2(22/2200*10)=-3.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(13/780*10)=-2.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ASAP1 [Title/Abstract] AND ADCY2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BLCA | TCGA-S5-A6DX-01A | ASAP1 | chr8 | 131226802 | - | ADCY2 | chr5 | 7784478 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000357668 | ENST00000338316 | ASAP1 | chr8 | 131226802 | - | ADCY2 | chr5 | 7784478 | + |
| Frame-shift | ENST00000357668 | ENST00000537121 | ASAP1 | chr8 | 131226802 | - | ADCY2 | chr5 | 7784478 | + |
| 5CDS-intron | ENST00000357668 | ENST00000513693 | ASAP1 | chr8 | 131226802 | - | ADCY2 | chr5 | 7784478 | + |
| Frame-shift | ENST00000518721 | ENST00000338316 | ASAP1 | chr8 | 131226802 | - | ADCY2 | chr5 | 7784478 | + |
| Frame-shift | ENST00000518721 | ENST00000537121 | ASAP1 | chr8 | 131226802 | - | ADCY2 | chr5 | 7784478 | + |
| 5CDS-intron | ENST00000518721 | ENST00000513693 | ASAP1 | chr8 | 131226802 | - | ADCY2 | chr5 | 7784478 | + |
| intron-3CDS | ENST00000520625 | ENST00000338316 | ASAP1 | chr8 | 131226802 | - | ADCY2 | chr5 | 7784478 | + |
| intron-3CDS | ENST00000520625 | ENST00000537121 | ASAP1 | chr8 | 131226802 | - | ADCY2 | chr5 | 7784478 | + |
| intron-intron | ENST00000520625 | ENST00000513693 | ASAP1 | chr8 | 131226802 | - | ADCY2 | chr5 | 7784478 | + |
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FusionProtFeatures for ASAP1_ADCY2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ASAP1 | ADCY2 |