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Fusion gene ID: 28894 |
FusionGeneSummary for PRPF8_RTF1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PRPF8_RTF1 | Fusion gene ID: 28894 | Hgene | Tgene | Gene symbol | PRPF8 | RTF1 | Gene ID | 10594 | 23168 |
| Gene name | pre-mRNA processing factor 8 | RTF1 homolog, Paf1/RNA polymerase II complex component | |
| Synonyms | HPRP8|PRP8|PRPC8|RP13|SNRNP220 | GTL7|KIAA0252 | |
| Cytomap | 17p13.3 | 15q15.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | pre-mRNA-processing-splicing factor 8220 kDa U5 snRNP-specific proteinPRP8 homologPRP8 pre-mRNA processing factor 8 homologU5 snRNP-specific protein (220 kD), ortholog of S. cerevisiae Prp8papoptosis-regulated protein 1apoptosis-regulated protein 2 | RNA polymerase-associated protein RTF1 homologRtf1, Paf1/RNA polymerase II complex component, homologortholog of mouse gene trap locus 7 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q6P2Q9 | Q92541 | |
| Ensembl transtripts involved in fusion gene | ENST00000304992, ENST00000572621, ENST00000575116, | ENST00000389629, ENST00000462276, | |
| Fusion gene scores | * DoF score | 7 X 9 X 1=63 | 7 X 8 X 3=168 |
| # samples | 9 | 9 | |
| ** MAII score | log2(9/63*10)=0.514573172829758 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(9/168*10)=-0.900464326449086 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: PRPF8 [Title/Abstract] AND RTF1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | PRPF8 | GO:0000244 | spliceosomal tri-snRNP complex assembly | 20595234 |
| Hgene | PRPF8 | GO:0000398 | mRNA splicing, via spliceosome | 28781166 |
| Tgene | RTF1 | GO:0019827 | stem cell population maintenance | 19345177 |
| Tgene | RTF1 | GO:0032968 | positive regulation of transcription elongation from RNA polymerase II promoter | 20178742 |
| Tgene | RTF1 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 20178742 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BI037412 | PRPF8 | chr17 | 1564320 | + | RTF1 | chr15 | 41767929 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000304992 | ENST00000389629 | PRPF8 | chr17 | 1564320 | + | RTF1 | chr15 | 41767929 | - |
| intron-intron | ENST00000304992 | ENST00000462276 | PRPF8 | chr17 | 1564320 | + | RTF1 | chr15 | 41767929 | - |
| intron-3CDS | ENST00000572621 | ENST00000389629 | PRPF8 | chr17 | 1564320 | + | RTF1 | chr15 | 41767929 | - |
| intron-intron | ENST00000572621 | ENST00000462276 | PRPF8 | chr17 | 1564320 | + | RTF1 | chr15 | 41767929 | - |
| intron-3CDS | ENST00000575116 | ENST00000389629 | PRPF8 | chr17 | 1564320 | + | RTF1 | chr15 | 41767929 | - |
| intron-intron | ENST00000575116 | ENST00000462276 | PRPF8 | chr17 | 1564320 | + | RTF1 | chr15 | 41767929 | - |
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FusionProtFeatures for PRPF8_RTF1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PRPF8 | RTF1 |