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Fusion gene ID: 2881 |
FusionGeneSummary for AS3MT_HERC4 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: AS3MT_HERC4 | Fusion gene ID: 2881 | Hgene | Tgene | Gene symbol | AS3MT | HERC4 | Gene ID | 57412 | 26091 |
| Gene name | arsenite methyltransferase | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | |
| Synonyms | CYT19 | - | |
| Cytomap | 10q24.32 | 10q21.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | arsenite methyltransferaseS-adenosyl-L-methionine:arsenic(III) methyltransferaseS-adenosylmethionine:arsenic (III) methyltransferasearsenic (+3 oxidation state) methyltransferasemethylarsonite methyltransferasemethyltransferase cyt19 | probable E3 ubiquitin-protein ligase HERC4HECT domain and RCC1-like domain-containing protein 4HECT-type E3 ubiquitin transferase HERC4hect domain and RLD 4 | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | Q9HBK9 | Q5GLZ8 | |
| Ensembl transtripts involved in fusion gene | ENST00000369880, | ENST00000277817, ENST00000412272, ENST00000395198, ENST00000373700, ENST00000395187, ENST00000480158, ENST00000492996, | |
| Fusion gene scores | * DoF score | 3 X 2 X 3=18 | 2 X 2 X 2=8 |
| # samples | 3 | 2 | |
| ** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: AS3MT [Title/Abstract] AND HERC4 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SARC | TCGA-FX-A76Y-01A | AS3MT | chr10 | 104636792 | + | HERC4 | chr10 | 69716733 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000369880 | ENST00000277817 | AS3MT | chr10 | 104636792 | + | HERC4 | chr10 | 69716733 | - |
| Frame-shift | ENST00000369880 | ENST00000412272 | AS3MT | chr10 | 104636792 | + | HERC4 | chr10 | 69716733 | - |
| Frame-shift | ENST00000369880 | ENST00000395198 | AS3MT | chr10 | 104636792 | + | HERC4 | chr10 | 69716733 | - |
| Frame-shift | ENST00000369880 | ENST00000373700 | AS3MT | chr10 | 104636792 | + | HERC4 | chr10 | 69716733 | - |
| 5CDS-3UTR | ENST00000369880 | ENST00000395187 | AS3MT | chr10 | 104636792 | + | HERC4 | chr10 | 69716733 | - |
| 5CDS-intron | ENST00000369880 | ENST00000480158 | AS3MT | chr10 | 104636792 | + | HERC4 | chr10 | 69716733 | - |
| 5CDS-intron | ENST00000369880 | ENST00000492996 | AS3MT | chr10 | 104636792 | + | HERC4 | chr10 | 69716733 | - |
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FusionProtFeatures for AS3MT_HERC4 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| AS3MT | HERC4 |