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Fusion gene ID: 28743 |
FusionGeneSummary for PRKCE_GPR126 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PRKCE_GPR126 | Fusion gene ID: 28743 | Hgene | Tgene | Gene symbol | PRKCE | GPR126 | Gene ID | 5581 | 57211 |
| Gene name | protein kinase C epsilon | adhesion G protein-coupled receptor G6 | |
| Synonyms | PKCE|nPKC-epsilon | APG1|DREG|GPR126|LCCS9|PR126|PS1TP2|VIGR | |
| Cytomap | 2p21 | 6q24.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | protein kinase C epsilon type | adhesion G-protein coupled receptor G6G-protein coupled receptor 126HBV PreS1-transactivated protein 2developmentally regulated G-protein-coupled receptorvascular-inducible G protein-coupled receptor | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q02156 | ||
| Ensembl transtripts involved in fusion gene | ENST00000306156, ENST00000467135, ENST00000394874, | ENST00000230173, ENST00000367608, ENST00000296932, ENST00000367609, ENST00000545477, | |
| Fusion gene scores | * DoF score | 3 X 4 X 3=36 | 2 X 2 X 2=8 |
| # samples | 5 | 2 | |
| ** MAII score | log2(5/36*10)=0.473931188332412 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: PRKCE [Title/Abstract] AND GPR126 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | PRKCE | GO:0006468 | protein phosphorylation | 18556656 |
| Hgene | PRKCE | GO:0018105 | peptidyl-serine phosphorylation | 15695813 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SKCM | TCGA-EB-A6L9-06A | PRKCE | chr2 | 46070202 | + | GPR126 | chr6 | 142758571 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000306156 | ENST00000230173 | PRKCE | chr2 | 46070202 | + | GPR126 | chr6 | 142758571 | + |
| In-frame | ENST00000306156 | ENST00000367608 | PRKCE | chr2 | 46070202 | + | GPR126 | chr6 | 142758571 | + |
| In-frame | ENST00000306156 | ENST00000296932 | PRKCE | chr2 | 46070202 | + | GPR126 | chr6 | 142758571 | + |
| In-frame | ENST00000306156 | ENST00000367609 | PRKCE | chr2 | 46070202 | + | GPR126 | chr6 | 142758571 | + |
| 5CDS-intron | ENST00000306156 | ENST00000545477 | PRKCE | chr2 | 46070202 | + | GPR126 | chr6 | 142758571 | + |
| 3UTR-3CDS | ENST00000467135 | ENST00000230173 | PRKCE | chr2 | 46070202 | + | GPR126 | chr6 | 142758571 | + |
| 3UTR-3CDS | ENST00000467135 | ENST00000367608 | PRKCE | chr2 | 46070202 | + | GPR126 | chr6 | 142758571 | + |
| 3UTR-3CDS | ENST00000467135 | ENST00000296932 | PRKCE | chr2 | 46070202 | + | GPR126 | chr6 | 142758571 | + |
| 3UTR-3CDS | ENST00000467135 | ENST00000367609 | PRKCE | chr2 | 46070202 | + | GPR126 | chr6 | 142758571 | + |
| 3UTR-intron | ENST00000467135 | ENST00000545477 | PRKCE | chr2 | 46070202 | + | GPR126 | chr6 | 142758571 | + |
| intron-3CDS | ENST00000394874 | ENST00000230173 | PRKCE | chr2 | 46070202 | + | GPR126 | chr6 | 142758571 | + |
| intron-3CDS | ENST00000394874 | ENST00000367608 | PRKCE | chr2 | 46070202 | + | GPR126 | chr6 | 142758571 | + |
| intron-3CDS | ENST00000394874 | ENST00000296932 | PRKCE | chr2 | 46070202 | + | GPR126 | chr6 | 142758571 | + |
| intron-3CDS | ENST00000394874 | ENST00000367609 | PRKCE | chr2 | 46070202 | + | GPR126 | chr6 | 142758571 | + |
| intron-intron | ENST00000394874 | ENST00000545477 | PRKCE | chr2 | 46070202 | + | GPR126 | chr6 | 142758571 | + |
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FusionProtFeatures for PRKCE_GPR126 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PRKCE | GPR126 |