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Fusion gene ID: 28667 |
FusionGeneSummary for PRKAA1_RPL37 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PRKAA1_RPL37 | Fusion gene ID: 28667 | Hgene | Tgene | Gene symbol | PRKAA1 | RPL37 | Gene ID | 5562 | 6167 |
| Gene name | protein kinase AMP-activated catalytic subunit alpha 1 | ribosomal protein L37 | |
| Synonyms | AMPK|AMPKa1 | L37 | |
| Cytomap | 5p13.1 | 5p13.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | 5'-AMP-activated protein kinase catalytic subunit alpha-15'-AMP-activated protein kinase, catalytic alpha-1 chainACACA kinaseAMP -activate kinase alpha 1 subunitAMP-activated protein kinase, catalytic, alpha-1AMPK alpha 1AMPK subunit alpha-1HMGCR k | 60S ribosomal protein L3760S ribosomal protein L37aG1.16large ribosomal subunit protein eL37 | |
| Modification date | 20180527 | 20180523 | |
| UniProtAcc | Q13131 | P61927 | |
| Ensembl transtripts involved in fusion gene | ENST00000397128, ENST00000354209, ENST00000296800, | ENST00000274242, ENST00000509877, ENST00000504562, ENST00000508493, | |
| Fusion gene scores | * DoF score | 2 X 1 X 2=4 | 2 X 2 X 2=8 |
| # samples | 2 | 2 | |
| ** MAII score | log2(2/4*10)=2.32192809488736 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: PRKAA1 [Title/Abstract] AND RPL37 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | PRKAA1 | GO:0006468 | protein phosphorylation | 17028174 |
| Hgene | PRKAA1 | GO:0010508 | positive regulation of autophagy | 22012985 |
| Hgene | PRKAA1 | GO:0010628 | positive regulation of gene expression | 17028174 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-B6-A0RS-01A | PRKAA1 | chr5 | 40798165 | - | RPL37 | chr5 | 40834708 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000397128 | ENST00000274242 | PRKAA1 | chr5 | 40798165 | - | RPL37 | chr5 | 40834708 | - |
| In-frame | ENST00000397128 | ENST00000509877 | PRKAA1 | chr5 | 40798165 | - | RPL37 | chr5 | 40834708 | - |
| 5CDS-5UTR | ENST00000397128 | ENST00000504562 | PRKAA1 | chr5 | 40798165 | - | RPL37 | chr5 | 40834708 | - |
| 5CDS-5UTR | ENST00000397128 | ENST00000508493 | PRKAA1 | chr5 | 40798165 | - | RPL37 | chr5 | 40834708 | - |
| In-frame | ENST00000354209 | ENST00000274242 | PRKAA1 | chr5 | 40798165 | - | RPL37 | chr5 | 40834708 | - |
| In-frame | ENST00000354209 | ENST00000509877 | PRKAA1 | chr5 | 40798165 | - | RPL37 | chr5 | 40834708 | - |
| 5CDS-5UTR | ENST00000354209 | ENST00000504562 | PRKAA1 | chr5 | 40798165 | - | RPL37 | chr5 | 40834708 | - |
| 5CDS-5UTR | ENST00000354209 | ENST00000508493 | PRKAA1 | chr5 | 40798165 | - | RPL37 | chr5 | 40834708 | - |
| In-frame | ENST00000296800 | ENST00000274242 | PRKAA1 | chr5 | 40798165 | - | RPL37 | chr5 | 40834708 | - |
| In-frame | ENST00000296800 | ENST00000509877 | PRKAA1 | chr5 | 40798165 | - | RPL37 | chr5 | 40834708 | - |
| 5CDS-5UTR | ENST00000296800 | ENST00000504562 | PRKAA1 | chr5 | 40798165 | - | RPL37 | chr5 | 40834708 | - |
| 5CDS-5UTR | ENST00000296800 | ENST00000508493 | PRKAA1 | chr5 | 40798165 | - | RPL37 | chr5 | 40834708 | - |
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FusionProtFeatures for PRKAA1_RPL37 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PRKAA1 | RPL37 |