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Fusion gene ID: 28629 |
FusionGeneSummary for PREP_DCBLD1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PREP_DCBLD1 | Fusion gene ID: 28629 | Hgene | Tgene | Gene symbol | PREP | DCBLD1 | Gene ID | 5550 | 285761 |
| Gene name | prolyl endopeptidase | discoidin, CUB and LCCL domain containing 1 | |
| Synonyms | PE|PEP | dJ94G16.1 | |
| Cytomap | 6q21 | 6q22.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | prolyl endopeptidasedJ355L5.1 (prolyl endopeptidase)post-proline cleaving enzymeprolyl oligopeptidase | discoidin, CUB and LCCL domain-containing protein 1 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | P48147 | Q8N8Z6 | |
| Ensembl transtripts involved in fusion gene | ENST00000369110, | ENST00000368503, ENST00000296955, ENST00000338728, ENST00000534777, | |
| Fusion gene scores | * DoF score | 12 X 7 X 5=420 | 4 X 3 X 4=48 |
| # samples | 12 | 4 | |
| ** MAII score | log2(12/420*10)=-1.8073549220576 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: PREP [Title/Abstract] AND DCBLD1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-A2-A04W-01A | PREP | chr6 | 105771540 | - | DCBLD1 | chr6 | 117824930 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000369110 | ENST00000368503 | PREP | chr6 | 105771540 | - | DCBLD1 | chr6 | 117824930 | + |
| Frame-shift | ENST00000369110 | ENST00000296955 | PREP | chr6 | 105771540 | - | DCBLD1 | chr6 | 117824930 | + |
| Frame-shift | ENST00000369110 | ENST00000338728 | PREP | chr6 | 105771540 | - | DCBLD1 | chr6 | 117824930 | + |
| 5CDS-intron | ENST00000369110 | ENST00000534777 | PREP | chr6 | 105771540 | - | DCBLD1 | chr6 | 117824930 | + |
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FusionProtFeatures for PREP_DCBLD1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PREP | DCBLD1 |