|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 28628 |
FusionGeneSummary for PREP_ATG5 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PREP_ATG5 | Fusion gene ID: 28628 | Hgene | Tgene | Gene symbol | PREP | ATG5 | Gene ID | 5550 | 9474 |
| Gene name | prolyl endopeptidase | autophagy related 5 | |
| Synonyms | PE|PEP | APG5|APG5-LIKE|APG5L|ASP|SCAR25|hAPG5 | |
| Cytomap | 6q21 | 6q21 | |
| Type of gene | protein-coding | protein-coding | |
| Description | prolyl endopeptidasedJ355L5.1 (prolyl endopeptidase)post-proline cleaving enzymeprolyl oligopeptidase | autophagy protein 5APG5 autophagy 5-likeATG5 autophagy related 5 homologapoptosis-specific protein | |
| Modification date | 20180523 | 20180527 | |
| UniProtAcc | P48147 | Q9H1Y0 | |
| Ensembl transtripts involved in fusion gene | ENST00000369110, | ENST00000343245, ENST00000369070, ENST00000369076, ENST00000360666, ENST00000475645, | |
| Fusion gene scores | * DoF score | 12 X 7 X 5=420 | 7 X 7 X 4=196 |
| # samples | 12 | 8 | |
| ** MAII score | log2(12/420*10)=-1.8073549220576 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/196*10)=-1.29278174922785 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: PREP [Title/Abstract] AND ATG5 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LUAD | TCGA-78-7153-01A | PREP | chr6 | 105816778 | - | ATG5 | chr6 | 106696119 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000369110 | ENST00000343245 | PREP | chr6 | 105816778 | - | ATG5 | chr6 | 106696119 | - |
| Frame-shift | ENST00000369110 | ENST00000369070 | PREP | chr6 | 105816778 | - | ATG5 | chr6 | 106696119 | - |
| Frame-shift | ENST00000369110 | ENST00000369076 | PREP | chr6 | 105816778 | - | ATG5 | chr6 | 106696119 | - |
| In-frame | ENST00000369110 | ENST00000360666 | PREP | chr6 | 105816778 | - | ATG5 | chr6 | 106696119 | - |
| 5CDS-intron | ENST00000369110 | ENST00000475645 | PREP | chr6 | 105816778 | - | ATG5 | chr6 | 106696119 | - |
Top |
FusionProtFeatures for PREP_ATG5 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PREP | ATG5 |