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Fusion gene ID: 28600 |
FusionGeneSummary for PRDM1_SLC22A16 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PRDM1_SLC22A16 | Fusion gene ID: 28600 | Hgene | Tgene | Gene symbol | PRDM1 | SLC22A16 | Gene ID | 639 | 85413 |
| Gene name | PR/SET domain 1 | solute carrier family 22 member 16 | |
| Synonyms | BLIMP1|PRDI-BF1 | CT2|FLIPT2|HEL-S-18|OAT6|OCT6|OKB1|dJ261K5.1 | |
| Cytomap | 6q21 | 6q21|6q21-q22.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | PR domain zinc finger protein 1B-lymphocyte-induced maturation protein 1BLIMP-1PR domain 1PR domain containing 1, with ZNF domainPRDI-binding factor-1beta-interferon gene positive-regulatory domain I binding factor | solute carrier family 22 member 16WUGSC:RG331P03.1carnitine transporter 2epididymis secretory protein Li 18flipt 2fly-like putative organic ion transporter 2fly-like putative transporter 2organic cation transporter 6organic cation transporter OKB1 | |
| Modification date | 20180527 | 20180522 | |
| UniProtAcc | O75626 | Q86VW1 | |
| Ensembl transtripts involved in fusion gene | ENST00000369091, ENST00000369096, ENST00000369089, | ENST00000368919, ENST00000330550, ENST00000439654, ENST00000456137, ENST00000461487, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 5 X 3 X 5=75 |
| # samples | 2 | 6 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(6/75*10)=-0.321928094887362 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: PRDM1 [Title/Abstract] AND SLC22A16 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | PRDM1 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 1851123 |
| Tgene | SLC22A16 | GO:0015695 | organic cation transport | 12089149|15963465 |
| Tgene | SLC22A16 | GO:0015879 | carnitine transport | 12089149 |
| Tgene | SLC22A16 | GO:0046717 | acid secretion | 12089149 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-A2-A04V-01A | PRDM1 | chr6 | 106554374 | + | SLC22A16 | chr6 | 110763978 | - |
| TCGA | LD | BRCA | TCGA-A2-A04V-01A | PRDM1 | chr6 | 106554374 | + | SLC22A16 | chr6 | 110778220 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000369091 | ENST00000368919 | PRDM1 | chr6 | 106554374 | + | SLC22A16 | chr6 | 110763978 | - |
| In-frame | ENST00000369091 | ENST00000330550 | PRDM1 | chr6 | 106554374 | + | SLC22A16 | chr6 | 110763978 | - |
| In-frame | ENST00000369091 | ENST00000439654 | PRDM1 | chr6 | 106554374 | + | SLC22A16 | chr6 | 110763978 | - |
| 5CDS-3UTR | ENST00000369091 | ENST00000456137 | PRDM1 | chr6 | 106554374 | + | SLC22A16 | chr6 | 110763978 | - |
| 5CDS-intron | ENST00000369091 | ENST00000461487 | PRDM1 | chr6 | 106554374 | + | SLC22A16 | chr6 | 110763978 | - |
| In-frame | ENST00000369096 | ENST00000368919 | PRDM1 | chr6 | 106554374 | + | SLC22A16 | chr6 | 110763978 | - |
| In-frame | ENST00000369096 | ENST00000330550 | PRDM1 | chr6 | 106554374 | + | SLC22A16 | chr6 | 110763978 | - |
| In-frame | ENST00000369096 | ENST00000439654 | PRDM1 | chr6 | 106554374 | + | SLC22A16 | chr6 | 110763978 | - |
| 5CDS-3UTR | ENST00000369096 | ENST00000456137 | PRDM1 | chr6 | 106554374 | + | SLC22A16 | chr6 | 110763978 | - |
| 5CDS-intron | ENST00000369096 | ENST00000461487 | PRDM1 | chr6 | 106554374 | + | SLC22A16 | chr6 | 110763978 | - |
| In-frame | ENST00000369089 | ENST00000368919 | PRDM1 | chr6 | 106554374 | + | SLC22A16 | chr6 | 110763978 | - |
| In-frame | ENST00000369089 | ENST00000330550 | PRDM1 | chr6 | 106554374 | + | SLC22A16 | chr6 | 110763978 | - |
| In-frame | ENST00000369089 | ENST00000439654 | PRDM1 | chr6 | 106554374 | + | SLC22A16 | chr6 | 110763978 | - |
| 5CDS-3UTR | ENST00000369089 | ENST00000456137 | PRDM1 | chr6 | 106554374 | + | SLC22A16 | chr6 | 110763978 | - |
| 5CDS-intron | ENST00000369089 | ENST00000461487 | PRDM1 | chr6 | 106554374 | + | SLC22A16 | chr6 | 110763978 | - |
| Frame-shift | ENST00000369091 | ENST00000368919 | PRDM1 | chr6 | 106554374 | + | SLC22A16 | chr6 | 110778220 | - |
| Frame-shift | ENST00000369091 | ENST00000330550 | PRDM1 | chr6 | 106554374 | + | SLC22A16 | chr6 | 110778220 | - |
| Frame-shift | ENST00000369091 | ENST00000439654 | PRDM1 | chr6 | 106554374 | + | SLC22A16 | chr6 | 110778220 | - |
| In-frame | ENST00000369091 | ENST00000456137 | PRDM1 | chr6 | 106554374 | + | SLC22A16 | chr6 | 110778220 | - |
| 5CDS-5UTR | ENST00000369091 | ENST00000461487 | PRDM1 | chr6 | 106554374 | + | SLC22A16 | chr6 | 110778220 | - |
| Frame-shift | ENST00000369096 | ENST00000368919 | PRDM1 | chr6 | 106554374 | + | SLC22A16 | chr6 | 110778220 | - |
| Frame-shift | ENST00000369096 | ENST00000330550 | PRDM1 | chr6 | 106554374 | + | SLC22A16 | chr6 | 110778220 | - |
| Frame-shift | ENST00000369096 | ENST00000439654 | PRDM1 | chr6 | 106554374 | + | SLC22A16 | chr6 | 110778220 | - |
| In-frame | ENST00000369096 | ENST00000456137 | PRDM1 | chr6 | 106554374 | + | SLC22A16 | chr6 | 110778220 | - |
| 5CDS-5UTR | ENST00000369096 | ENST00000461487 | PRDM1 | chr6 | 106554374 | + | SLC22A16 | chr6 | 110778220 | - |
| Frame-shift | ENST00000369089 | ENST00000368919 | PRDM1 | chr6 | 106554374 | + | SLC22A16 | chr6 | 110778220 | - |
| Frame-shift | ENST00000369089 | ENST00000330550 | PRDM1 | chr6 | 106554374 | + | SLC22A16 | chr6 | 110778220 | - |
| Frame-shift | ENST00000369089 | ENST00000439654 | PRDM1 | chr6 | 106554374 | + | SLC22A16 | chr6 | 110778220 | - |
| In-frame | ENST00000369089 | ENST00000456137 | PRDM1 | chr6 | 106554374 | + | SLC22A16 | chr6 | 110778220 | - |
| 5CDS-5UTR | ENST00000369089 | ENST00000461487 | PRDM1 | chr6 | 106554374 | + | SLC22A16 | chr6 | 110778220 | - |
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FusionProtFeatures for PRDM1_SLC22A16 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PRDM1 | SLC22A16 |