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Fusion gene ID: 28585 |
FusionGeneSummary for PRCC_TFE3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PRCC_TFE3 | Fusion gene ID: 28585 | Hgene | Tgene | Gene symbol | PRCC | TFE3 | Gene ID | 5546 | 7030 |
| Gene name | papillary renal cell carcinoma (translocation-associated) | transcription factor binding to IGHM enhancer 3 | |
| Synonyms | RCCP1|TPRC | RCCP2|RCCX1|TFEA|bHLHe33 | |
| Cytomap | 1q23.1 | Xp11.23 | |
| Type of gene | protein-coding | protein-coding | |
| Description | proline-rich protein PRCCpapillary renal cell carcinoma translocation-associated gene protein | transcription factor E3class E basic helix-loop-helix protein 33transcription factor E family, member Atranscription factor for IgH enhancertranscription factor for immunoglobulin heavy-chain enhancer 3 | |
| Modification date | 20180522 | 20180527 | |
| UniProtAcc | Q92733 | P19532 | |
| Ensembl transtripts involved in fusion gene | ENST00000271526, ENST00000353233, ENST00000491853, | ENST00000315869, ENST00000487451, | |
| Fusion gene scores | * DoF score | 6 X 1 X 7=42 | 10 X 9 X 4=360 |
| # samples | 9 | 19 | |
| ** MAII score | log2(9/42*10)=1.09953567355091 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(19/360*10)=-0.921997487998727 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: PRCC [Title/Abstract] AND TFE3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | PRCC | GO:0007093 | mitotic cell cycle checkpoint | 11717438 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | KIRP | TCGA-BQ-5887-01A | PRCC | chr1 | 156738031 | + | TFE3 | chrX | 48895967 | - |
| TCGA | RV | KIRP | TCGA-BQ-7050-01A | PRCC | chr1 | 156738031 | + | TFE3 | chrX | 48895967 | - |
| TCGA | RV | KIRP | TCGA-BQ-5882-01A | PRCC | chr1 | 156738031 | + | TFE3 | chrX | 48895967 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000271526 | ENST00000315869 | PRCC | chr1 | 156738031 | + | TFE3 | chrX | 48895967 | - |
| 5CDS-5UTR | ENST00000271526 | ENST00000487451 | PRCC | chr1 | 156738031 | + | TFE3 | chrX | 48895967 | - |
| In-frame | ENST00000353233 | ENST00000315869 | PRCC | chr1 | 156738031 | + | TFE3 | chrX | 48895967 | - |
| 5CDS-5UTR | ENST00000353233 | ENST00000487451 | PRCC | chr1 | 156738031 | + | TFE3 | chrX | 48895967 | - |
| intron-3CDS | ENST00000491853 | ENST00000315869 | PRCC | chr1 | 156738031 | + | TFE3 | chrX | 48895967 | - |
| intron-5UTR | ENST00000491853 | ENST00000487451 | PRCC | chr1 | 156738031 | + | TFE3 | chrX | 48895967 | - |
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FusionProtFeatures for PRCC_TFE3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PRCC | TFE3 |