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Fusion gene ID: 28580 |
FusionGeneSummary for PRC1_VPS33B |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PRC1_VPS33B | Fusion gene ID: 28580 | Hgene | Tgene | Gene symbol | PRC1 | VPS33B | Gene ID | 9055 | 26276 |
| Gene name | protein regulator of cytokinesis 1 | VPS33B, late endosome and lysosome associated | |
| Synonyms | ASE1 | - | |
| Cytomap | 15q26.1 | 15q26.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | protein regulator of cytokinesis 1anaphase spindle elongation 1 homologprotein regulating cytokinesis 1 | vacuolar protein sorting-associated protein 33Bvacuolar protein sorting 33 homolog Bvacuolar protein sorting 33-like protein B | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | O43663 | Q9H267 | |
| Ensembl transtripts involved in fusion gene | ENST00000394249, ENST00000361919, ENST00000361188, ENST00000442656, ENST00000556129, | ENST00000333371, ENST00000535843, ENST00000535906, ENST00000557358, | |
| Fusion gene scores | * DoF score | 2 X 3 X 2=12 | 4 X 4 X 4=64 |
| # samples | 3 | 5 | |
| ** MAII score | log2(3/12*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(5/64*10)=-0.356143810225275 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: PRC1 [Title/Abstract] AND VPS33B [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | PRC1 | GO:0032465 | regulation of cytokinesis | 17351640 |
| Tgene | VPS33B | GO:0016192 | vesicle-mediated transport | 15790593 |
| Tgene | VPS33B | GO:0032400 | melanosome localization | 15790593 |
| Tgene | VPS33B | GO:0032418 | lysosome localization | 15790593 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | OV | TCGA-25-2397-01A | PRC1 | chr15 | 91527923 | - | VPS33B | chr15 | 91561115 | - |
| TCGA | LD | OV | TCGA-24-1556-01A | PRC1 | chr15 | 91523472 | - | VPS33B | chr15 | 91542284 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000394249 | ENST00000333371 | PRC1 | chr15 | 91527923 | - | VPS33B | chr15 | 91561115 | - |
| 5CDS-5UTR | ENST00000394249 | ENST00000535843 | PRC1 | chr15 | 91527923 | - | VPS33B | chr15 | 91561115 | - |
| 5CDS-intron | ENST00000394249 | ENST00000535906 | PRC1 | chr15 | 91527923 | - | VPS33B | chr15 | 91561115 | - |
| 5CDS-intron | ENST00000394249 | ENST00000557358 | PRC1 | chr15 | 91527923 | - | VPS33B | chr15 | 91561115 | - |
| In-frame | ENST00000361919 | ENST00000333371 | PRC1 | chr15 | 91527923 | - | VPS33B | chr15 | 91561115 | - |
| 5CDS-5UTR | ENST00000361919 | ENST00000535843 | PRC1 | chr15 | 91527923 | - | VPS33B | chr15 | 91561115 | - |
| 5CDS-intron | ENST00000361919 | ENST00000535906 | PRC1 | chr15 | 91527923 | - | VPS33B | chr15 | 91561115 | - |
| 5CDS-intron | ENST00000361919 | ENST00000557358 | PRC1 | chr15 | 91527923 | - | VPS33B | chr15 | 91561115 | - |
| In-frame | ENST00000361188 | ENST00000333371 | PRC1 | chr15 | 91527923 | - | VPS33B | chr15 | 91561115 | - |
| 5CDS-5UTR | ENST00000361188 | ENST00000535843 | PRC1 | chr15 | 91527923 | - | VPS33B | chr15 | 91561115 | - |
| 5CDS-intron | ENST00000361188 | ENST00000535906 | PRC1 | chr15 | 91527923 | - | VPS33B | chr15 | 91561115 | - |
| 5CDS-intron | ENST00000361188 | ENST00000557358 | PRC1 | chr15 | 91527923 | - | VPS33B | chr15 | 91561115 | - |
| In-frame | ENST00000442656 | ENST00000333371 | PRC1 | chr15 | 91527923 | - | VPS33B | chr15 | 91561115 | - |
| 5CDS-5UTR | ENST00000442656 | ENST00000535843 | PRC1 | chr15 | 91527923 | - | VPS33B | chr15 | 91561115 | - |
| 5CDS-intron | ENST00000442656 | ENST00000535906 | PRC1 | chr15 | 91527923 | - | VPS33B | chr15 | 91561115 | - |
| 5CDS-intron | ENST00000442656 | ENST00000557358 | PRC1 | chr15 | 91527923 | - | VPS33B | chr15 | 91561115 | - |
| 5UTR-3CDS | ENST00000556129 | ENST00000333371 | PRC1 | chr15 | 91527923 | - | VPS33B | chr15 | 91561115 | - |
| 5UTR-5UTR | ENST00000556129 | ENST00000535843 | PRC1 | chr15 | 91527923 | - | VPS33B | chr15 | 91561115 | - |
| 5UTR-intron | ENST00000556129 | ENST00000535906 | PRC1 | chr15 | 91527923 | - | VPS33B | chr15 | 91561115 | - |
| 5UTR-intron | ENST00000556129 | ENST00000557358 | PRC1 | chr15 | 91527923 | - | VPS33B | chr15 | 91561115 | - |
| Frame-shift | ENST00000394249 | ENST00000333371 | PRC1 | chr15 | 91523472 | - | VPS33B | chr15 | 91542284 | - |
| Frame-shift | ENST00000394249 | ENST00000535843 | PRC1 | chr15 | 91523472 | - | VPS33B | chr15 | 91542284 | - |
| Frame-shift | ENST00000394249 | ENST00000535906 | PRC1 | chr15 | 91523472 | - | VPS33B | chr15 | 91542284 | - |
| 5CDS-intron | ENST00000394249 | ENST00000557358 | PRC1 | chr15 | 91523472 | - | VPS33B | chr15 | 91542284 | - |
| Frame-shift | ENST00000361919 | ENST00000333371 | PRC1 | chr15 | 91523472 | - | VPS33B | chr15 | 91542284 | - |
| Frame-shift | ENST00000361919 | ENST00000535843 | PRC1 | chr15 | 91523472 | - | VPS33B | chr15 | 91542284 | - |
| Frame-shift | ENST00000361919 | ENST00000535906 | PRC1 | chr15 | 91523472 | - | VPS33B | chr15 | 91542284 | - |
| 5CDS-intron | ENST00000361919 | ENST00000557358 | PRC1 | chr15 | 91523472 | - | VPS33B | chr15 | 91542284 | - |
| Frame-shift | ENST00000361188 | ENST00000333371 | PRC1 | chr15 | 91523472 | - | VPS33B | chr15 | 91542284 | - |
| Frame-shift | ENST00000361188 | ENST00000535843 | PRC1 | chr15 | 91523472 | - | VPS33B | chr15 | 91542284 | - |
| Frame-shift | ENST00000361188 | ENST00000535906 | PRC1 | chr15 | 91523472 | - | VPS33B | chr15 | 91542284 | - |
| 5CDS-intron | ENST00000361188 | ENST00000557358 | PRC1 | chr15 | 91523472 | - | VPS33B | chr15 | 91542284 | - |
| Frame-shift | ENST00000442656 | ENST00000333371 | PRC1 | chr15 | 91523472 | - | VPS33B | chr15 | 91542284 | - |
| Frame-shift | ENST00000442656 | ENST00000535843 | PRC1 | chr15 | 91523472 | - | VPS33B | chr15 | 91542284 | - |
| Frame-shift | ENST00000442656 | ENST00000535906 | PRC1 | chr15 | 91523472 | - | VPS33B | chr15 | 91542284 | - |
| 5CDS-intron | ENST00000442656 | ENST00000557358 | PRC1 | chr15 | 91523472 | - | VPS33B | chr15 | 91542284 | - |
| intron-3CDS | ENST00000556129 | ENST00000333371 | PRC1 | chr15 | 91523472 | - | VPS33B | chr15 | 91542284 | - |
| intron-3CDS | ENST00000556129 | ENST00000535843 | PRC1 | chr15 | 91523472 | - | VPS33B | chr15 | 91542284 | - |
| intron-3CDS | ENST00000556129 | ENST00000535906 | PRC1 | chr15 | 91523472 | - | VPS33B | chr15 | 91542284 | - |
| intron-intron | ENST00000556129 | ENST00000557358 | PRC1 | chr15 | 91523472 | - | VPS33B | chr15 | 91542284 | - |
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FusionProtFeatures for PRC1_VPS33B |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PRC1 | VPS33B |