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Fusion gene ID: 28563 |
FusionGeneSummary for PPWD1_NLN |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PPWD1_NLN | Fusion gene ID: 28563 | Hgene | Tgene | Gene symbol | PPWD1 | NLN | Gene ID | 23398 | 57486 |
| Gene name | peptidylprolyl isomerase domain and WD repeat containing 1 | neurolysin | |
| Synonyms | - | AGTBP|EP24.16|MEP|MOP | |
| Cytomap | 5q12.3 | 5q12.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | peptidylprolyl isomerase domain and WD repeat-containing protein 1spliceosome-associated cyclophilin | neurolysin, mitochondrialangiotensin binding proteinendopeptidase 24.16microsomal endopeptidasemitochondrial oligopeptidase Mneurolysin (metallopeptidase M3 family)neurotensin endopeptidase | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q96BP3 | Q9BYT8 | |
| Ensembl transtripts involved in fusion gene | ENST00000261308, ENST00000535264, ENST00000538977, | ENST00000380985, ENST00000502464, ENST00000515595, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 4 X 3 X 3=36 |
| # samples | 2 | 4 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: PPWD1 [Title/Abstract] AND NLN [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | PPWD1 | GO:0000413 | protein peptidyl-prolyl isomerization | 20676357 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LUAD | TCGA-50-5930-01A | PPWD1 | chr5 | 64875440 | + | NLN | chr5 | 65076006 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000261308 | ENST00000380985 | PPWD1 | chr5 | 64875440 | + | NLN | chr5 | 65076006 | + |
| In-frame | ENST00000261308 | ENST00000502464 | PPWD1 | chr5 | 64875440 | + | NLN | chr5 | 65076006 | + |
| 5CDS-intron | ENST00000261308 | ENST00000515595 | PPWD1 | chr5 | 64875440 | + | NLN | chr5 | 65076006 | + |
| In-frame | ENST00000535264 | ENST00000380985 | PPWD1 | chr5 | 64875440 | + | NLN | chr5 | 65076006 | + |
| In-frame | ENST00000535264 | ENST00000502464 | PPWD1 | chr5 | 64875440 | + | NLN | chr5 | 65076006 | + |
| 5CDS-intron | ENST00000535264 | ENST00000515595 | PPWD1 | chr5 | 64875440 | + | NLN | chr5 | 65076006 | + |
| In-frame | ENST00000538977 | ENST00000380985 | PPWD1 | chr5 | 64875440 | + | NLN | chr5 | 65076006 | + |
| In-frame | ENST00000538977 | ENST00000502464 | PPWD1 | chr5 | 64875440 | + | NLN | chr5 | 65076006 | + |
| 5CDS-intron | ENST00000538977 | ENST00000515595 | PPWD1 | chr5 | 64875440 | + | NLN | chr5 | 65076006 | + |
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FusionProtFeatures for PPWD1_NLN |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PPWD1 | NLN |