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Fusion gene ID: 2853 |
FusionGeneSummary for ARSA_ANKLE2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ARSA_ANKLE2 | Fusion gene ID: 2853 | Hgene | Tgene | Gene symbol | ARSA | ANKLE2 | Gene ID | 410 | 23141 |
| Gene name | arylsulfatase A | ankyrin repeat and LEM domain containing 2 | |
| Synonyms | ASA|MLD | KIAA0692|LEMD7|Lem4|MCPH16 | |
| Cytomap | 22q13.33 | 12q24.33 | |
| Type of gene | protein-coding | protein-coding | |
| Description | arylsulfatase Acerebroside-sulfatase | ankyrin repeat and LEM domain-containing protein 2LEM domain containing 7LEM domain-containing protein 4 | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | P15289 | Q86XL3 | |
| Ensembl transtripts involved in fusion gene | ENST00000610191, ENST00000356098, ENST00000216124, ENST00000547307, ENST00000547805, ENST00000395621, ENST00000453344, ENST00000395619, | ENST00000539605, ENST00000357997, ENST00000542282, ENST00000542657, ENST00000542374, ENST00000337516, | |
| Fusion gene scores | * DoF score | 2 X 2 X 1=4 | 5 X 5 X 1=25 |
| # samples | 2 | 5 | |
| ** MAII score | log2(2/4*10)=2.32192809488736 | log2(5/25*10)=1 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: ARSA [Title/Abstract] AND ANKLE2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | ANKLE2 | GO:0007417 | central nervous system development | 25259927 |
| Tgene | ANKLE2 | GO:0035307 | positive regulation of protein dephosphorylation | 22770216 |
| Tgene | ANKLE2 | GO:0042326 | negative regulation of phosphorylation | 22770216 |
| Tgene | ANKLE2 | GO:0043066 | negative regulation of apoptotic process | 25259927 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BF898639 | ARSA | chr22 | 51066034 | + | ANKLE2 | chr12 | 133313420 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000610191 | ENST00000539605 | ARSA | chr22 | 51066034 | + | ANKLE2 | chr12 | 133313420 | + |
| intron-intron | ENST00000610191 | ENST00000357997 | ARSA | chr22 | 51066034 | + | ANKLE2 | chr12 | 133313420 | + |
| intron-intron | ENST00000610191 | ENST00000542282 | ARSA | chr22 | 51066034 | + | ANKLE2 | chr12 | 133313420 | + |
| intron-intron | ENST00000610191 | ENST00000542657 | ARSA | chr22 | 51066034 | + | ANKLE2 | chr12 | 133313420 | + |
| intron-intron | ENST00000610191 | ENST00000542374 | ARSA | chr22 | 51066034 | + | ANKLE2 | chr12 | 133313420 | + |
| intron-intron | ENST00000610191 | ENST00000337516 | ARSA | chr22 | 51066034 | + | ANKLE2 | chr12 | 133313420 | + |
| intron-intron | ENST00000356098 | ENST00000539605 | ARSA | chr22 | 51066034 | + | ANKLE2 | chr12 | 133313420 | + |
| intron-intron | ENST00000356098 | ENST00000357997 | ARSA | chr22 | 51066034 | + | ANKLE2 | chr12 | 133313420 | + |
| intron-intron | ENST00000356098 | ENST00000542282 | ARSA | chr22 | 51066034 | + | ANKLE2 | chr12 | 133313420 | + |
| intron-intron | ENST00000356098 | ENST00000542657 | ARSA | chr22 | 51066034 | + | ANKLE2 | chr12 | 133313420 | + |
| intron-intron | ENST00000356098 | ENST00000542374 | ARSA | chr22 | 51066034 | + | ANKLE2 | chr12 | 133313420 | + |
| intron-intron | ENST00000356098 | ENST00000337516 | ARSA | chr22 | 51066034 | + | ANKLE2 | chr12 | 133313420 | + |
| intron-intron | ENST00000216124 | ENST00000539605 | ARSA | chr22 | 51066034 | + | ANKLE2 | chr12 | 133313420 | + |
| intron-intron | ENST00000216124 | ENST00000357997 | ARSA | chr22 | 51066034 | + | ANKLE2 | chr12 | 133313420 | + |
| intron-intron | ENST00000216124 | ENST00000542282 | ARSA | chr22 | 51066034 | + | ANKLE2 | chr12 | 133313420 | + |
| intron-intron | ENST00000216124 | ENST00000542657 | ARSA | chr22 | 51066034 | + | ANKLE2 | chr12 | 133313420 | + |
| intron-intron | ENST00000216124 | ENST00000542374 | ARSA | chr22 | 51066034 | + | ANKLE2 | chr12 | 133313420 | + |
| intron-intron | ENST00000216124 | ENST00000337516 | ARSA | chr22 | 51066034 | + | ANKLE2 | chr12 | 133313420 | + |
| intron-intron | ENST00000547307 | ENST00000539605 | ARSA | chr22 | 51066034 | + | ANKLE2 | chr12 | 133313420 | + |
| intron-intron | ENST00000547307 | ENST00000357997 | ARSA | chr22 | 51066034 | + | ANKLE2 | chr12 | 133313420 | + |
| intron-intron | ENST00000547307 | ENST00000542282 | ARSA | chr22 | 51066034 | + | ANKLE2 | chr12 | 133313420 | + |
| intron-intron | ENST00000547307 | ENST00000542657 | ARSA | chr22 | 51066034 | + | ANKLE2 | chr12 | 133313420 | + |
| intron-intron | ENST00000547307 | ENST00000542374 | ARSA | chr22 | 51066034 | + | ANKLE2 | chr12 | 133313420 | + |
| intron-intron | ENST00000547307 | ENST00000337516 | ARSA | chr22 | 51066034 | + | ANKLE2 | chr12 | 133313420 | + |
| intron-intron | ENST00000547805 | ENST00000539605 | ARSA | chr22 | 51066034 | + | ANKLE2 | chr12 | 133313420 | + |
| intron-intron | ENST00000547805 | ENST00000357997 | ARSA | chr22 | 51066034 | + | ANKLE2 | chr12 | 133313420 | + |
| intron-intron | ENST00000547805 | ENST00000542282 | ARSA | chr22 | 51066034 | + | ANKLE2 | chr12 | 133313420 | + |
| intron-intron | ENST00000547805 | ENST00000542657 | ARSA | chr22 | 51066034 | + | ANKLE2 | chr12 | 133313420 | + |
| intron-intron | ENST00000547805 | ENST00000542374 | ARSA | chr22 | 51066034 | + | ANKLE2 | chr12 | 133313420 | + |
| intron-intron | ENST00000547805 | ENST00000337516 | ARSA | chr22 | 51066034 | + | ANKLE2 | chr12 | 133313420 | + |
| intron-intron | ENST00000395621 | ENST00000539605 | ARSA | chr22 | 51066034 | + | ANKLE2 | chr12 | 133313420 | + |
| intron-intron | ENST00000395621 | ENST00000357997 | ARSA | chr22 | 51066034 | + | ANKLE2 | chr12 | 133313420 | + |
| intron-intron | ENST00000395621 | ENST00000542282 | ARSA | chr22 | 51066034 | + | ANKLE2 | chr12 | 133313420 | + |
| intron-intron | ENST00000395621 | ENST00000542657 | ARSA | chr22 | 51066034 | + | ANKLE2 | chr12 | 133313420 | + |
| intron-intron | ENST00000395621 | ENST00000542374 | ARSA | chr22 | 51066034 | + | ANKLE2 | chr12 | 133313420 | + |
| intron-intron | ENST00000395621 | ENST00000337516 | ARSA | chr22 | 51066034 | + | ANKLE2 | chr12 | 133313420 | + |
| intron-intron | ENST00000453344 | ENST00000539605 | ARSA | chr22 | 51066034 | + | ANKLE2 | chr12 | 133313420 | + |
| intron-intron | ENST00000453344 | ENST00000357997 | ARSA | chr22 | 51066034 | + | ANKLE2 | chr12 | 133313420 | + |
| intron-intron | ENST00000453344 | ENST00000542282 | ARSA | chr22 | 51066034 | + | ANKLE2 | chr12 | 133313420 | + |
| intron-intron | ENST00000453344 | ENST00000542657 | ARSA | chr22 | 51066034 | + | ANKLE2 | chr12 | 133313420 | + |
| intron-intron | ENST00000453344 | ENST00000542374 | ARSA | chr22 | 51066034 | + | ANKLE2 | chr12 | 133313420 | + |
| intron-intron | ENST00000453344 | ENST00000337516 | ARSA | chr22 | 51066034 | + | ANKLE2 | chr12 | 133313420 | + |
| intron-intron | ENST00000395619 | ENST00000539605 | ARSA | chr22 | 51066034 | + | ANKLE2 | chr12 | 133313420 | + |
| intron-intron | ENST00000395619 | ENST00000357997 | ARSA | chr22 | 51066034 | + | ANKLE2 | chr12 | 133313420 | + |
| intron-intron | ENST00000395619 | ENST00000542282 | ARSA | chr22 | 51066034 | + | ANKLE2 | chr12 | 133313420 | + |
| intron-intron | ENST00000395619 | ENST00000542657 | ARSA | chr22 | 51066034 | + | ANKLE2 | chr12 | 133313420 | + |
| intron-intron | ENST00000395619 | ENST00000542374 | ARSA | chr22 | 51066034 | + | ANKLE2 | chr12 | 133313420 | + |
| intron-intron | ENST00000395619 | ENST00000337516 | ARSA | chr22 | 51066034 | + | ANKLE2 | chr12 | 133313420 | + |
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FusionProtFeatures for ARSA_ANKLE2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ARSA | ANKLE2 |