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Fusion gene ID: 28519 |
FusionGeneSummary for PPP6R1_DPRX |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PPP6R1_DPRX | Fusion gene ID: 28519 | Hgene | Tgene | Gene symbol | PPP6R1 | DPRX | Gene ID | 22870 | 503834 |
| Gene name | protein phosphatase 6 regulatory subunit 1 | divergent-paired related homeobox | |
| Synonyms | KIAA1115|PP6R1|SAP190|SAPS1 | - | |
| Cytomap | 19q13.42 | 19q13.42 | |
| Type of gene | protein-coding | protein-coding | |
| Description | serine/threonine-protein phosphatase 6 regulatory subunit 1SAPS domain family, member 1 | divergent paired-related homeobox | |
| Modification date | 20180519 | 20180403 | |
| UniProtAcc | Q9UPN7 | A6NFQ7 | |
| Ensembl transtripts involved in fusion gene | ENST00000412770, ENST00000587283, | ENST00000376650, | |
| Fusion gene scores | * DoF score | 5 X 4 X 2=40 | 3 X 2 X 3=18 |
| # samples | 13 | 3 | |
| ** MAII score | log2(13/40*10)=1.70043971814109 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: PPP6R1 [Title/Abstract] AND DPRX [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | PPP6R1 | GO:0043666 | regulation of phosphoprotein phosphatase activity | 16716191 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-AO-A12C-01A | PPP6R1 | chr19 | 55769803 | - | DPRX | chr19 | 54135316 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-5UTR | ENST00000412770 | ENST00000376650 | PPP6R1 | chr19 | 55769803 | - | DPRX | chr19 | 54135316 | + |
| intron-5UTR | ENST00000587283 | ENST00000376650 | PPP6R1 | chr19 | 55769803 | - | DPRX | chr19 | 54135316 | + |
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FusionProtFeatures for PPP6R1_DPRX |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PPP6R1 | DPRX |