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Fusion gene ID: 28492 |
FusionGeneSummary for PPP3R1_TTC27 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PPP3R1_TTC27 | Fusion gene ID: 28492 | Hgene | Tgene | Gene symbol | PPP3R1 | TTC27 | Gene ID | 5534 | 55622 |
| Gene name | protein phosphatase 3 regulatory subunit B, alpha | tetratricopeptide repeat domain 27 | |
| Synonyms | CALNB1|CNB|CNB1 | - | |
| Cytomap | 2p14 | 2p22.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | calcineurin subunit B type 1calcineurin B, type I (19kDa)protein phosphatase 2B regulatory subunit 1protein phosphatase 2B regulatory subunit B alphaprotein phosphatase 3 (formerly 2B), regulatory subunit B (19kD), alpha isoform (calcineurin B, type I | tetratricopeptide repeat protein 27TPR repeat protein 27 | |
| Modification date | 20180522 | 20180519 | |
| UniProtAcc | P63098 | Q6P3X3 | |
| Ensembl transtripts involved in fusion gene | ENST00000234310, ENST00000409752, ENST00000409377, | ENST00000317907, | |
| Fusion gene scores | * DoF score | 4 X 3 X 3=36 | 4 X 4 X 3=48 |
| # samples | 4 | 5 | |
| ** MAII score | log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(5/48*10)=0.0588936890535686 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: PPP3R1 [Title/Abstract] AND TTC27 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | PPP3R1 | GO:0033173 | calcineurin-NFAT signaling cascade | 22688515 |
| Hgene | PPP3R1 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 22688515 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-A2-A0YG-01A | PPP3R1 | chr2 | 68479257 | - | TTC27 | chr2 | 33007693 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000234310 | ENST00000317907 | PPP3R1 | chr2 | 68479257 | - | TTC27 | chr2 | 33007693 | + |
| intron-3CDS | ENST00000409752 | ENST00000317907 | PPP3R1 | chr2 | 68479257 | - | TTC27 | chr2 | 33007693 | + |
| intron-3CDS | ENST00000409377 | ENST00000317907 | PPP3R1 | chr2 | 68479257 | - | TTC27 | chr2 | 33007693 | + |
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FusionProtFeatures for PPP3R1_TTC27 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PPP3R1 | TTC27 |