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Fusion gene ID: 28487 |
FusionGeneSummary for PPP3CC_PSD3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PPP3CC_PSD3 | Fusion gene ID: 28487 | Hgene | Tgene | Gene symbol | PPP3CC | PSD3 | Gene ID | 5533 | 23362 |
| Gene name | protein phosphatase 3 catalytic subunit gamma | pleckstrin and Sec7 domain containing 3 | |
| Synonyms | CALNA3|CNA3|PP2Bgamma | EFA6D|EFA6R|HCA67 | |
| Cytomap | 8p21.3 | 8p22 | |
| Type of gene | protein-coding | protein-coding | |
| Description | serine/threonine-protein phosphatase 2B catalytic subunit gamma isoformCAM-PRP catalytic subunitcalcineurin, testis-specific catalytic subunitcalmodulin-dependent calcineurin A subunit gamma isoformprotein phosphatase 2B, catalytic subunit, gamma isof | PH and SEC7 domain-containing protein 3ADP-ribosylation factor guanine nucleotide factor 6epididymis tissue protein Li 20mPexchange factor for ADP-ribosylation factor guanine nucleotide factor 6exchange factor for ADP-ribosylation factor guanine nucle | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P48454 | Q9NYI0 | |
| Ensembl transtripts involved in fusion gene | ENST00000518852, ENST00000240139, ENST00000289963, ENST00000397775, | ENST00000327040, ENST00000440756, ENST00000286485, ENST00000428502, ENST00000523619, ENST00000520789, | |
| Fusion gene scores | * DoF score | 7 X 5 X 6=210 | 4 X 4 X 2=32 |
| # samples | 10 | 4 | |
| ** MAII score | log2(10/210*10)=-1.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: PPP3CC [Title/Abstract] AND PSD3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | PPP3CC | GO:0006470 | protein dephosphorylation | 19154138 |
| Hgene | PPP3CC | GO:0033173 | calcineurin-NFAT signaling cascade | 19154138 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BF512520 | PPP3CC | chr8 | 22298971 | + | PSD3 | chr8 | 18662415 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000518852 | ENST00000327040 | PPP3CC | chr8 | 22298971 | + | PSD3 | chr8 | 18662415 | - |
| 5CDS-intron | ENST00000518852 | ENST00000440756 | PPP3CC | chr8 | 22298971 | + | PSD3 | chr8 | 18662415 | - |
| 5CDS-intron | ENST00000518852 | ENST00000286485 | PPP3CC | chr8 | 22298971 | + | PSD3 | chr8 | 18662415 | - |
| 5CDS-intron | ENST00000518852 | ENST00000428502 | PPP3CC | chr8 | 22298971 | + | PSD3 | chr8 | 18662415 | - |
| 5CDS-intron | ENST00000518852 | ENST00000523619 | PPP3CC | chr8 | 22298971 | + | PSD3 | chr8 | 18662415 | - |
| 5CDS-intron | ENST00000518852 | ENST00000520789 | PPP3CC | chr8 | 22298971 | + | PSD3 | chr8 | 18662415 | - |
| 5CDS-intron | ENST00000240139 | ENST00000327040 | PPP3CC | chr8 | 22298971 | + | PSD3 | chr8 | 18662415 | - |
| 5CDS-intron | ENST00000240139 | ENST00000440756 | PPP3CC | chr8 | 22298971 | + | PSD3 | chr8 | 18662415 | - |
| 5CDS-intron | ENST00000240139 | ENST00000286485 | PPP3CC | chr8 | 22298971 | + | PSD3 | chr8 | 18662415 | - |
| 5CDS-intron | ENST00000240139 | ENST00000428502 | PPP3CC | chr8 | 22298971 | + | PSD3 | chr8 | 18662415 | - |
| 5CDS-intron | ENST00000240139 | ENST00000523619 | PPP3CC | chr8 | 22298971 | + | PSD3 | chr8 | 18662415 | - |
| 5CDS-intron | ENST00000240139 | ENST00000520789 | PPP3CC | chr8 | 22298971 | + | PSD3 | chr8 | 18662415 | - |
| 5CDS-intron | ENST00000289963 | ENST00000327040 | PPP3CC | chr8 | 22298971 | + | PSD3 | chr8 | 18662415 | - |
| 5CDS-intron | ENST00000289963 | ENST00000440756 | PPP3CC | chr8 | 22298971 | + | PSD3 | chr8 | 18662415 | - |
| 5CDS-intron | ENST00000289963 | ENST00000286485 | PPP3CC | chr8 | 22298971 | + | PSD3 | chr8 | 18662415 | - |
| 5CDS-intron | ENST00000289963 | ENST00000428502 | PPP3CC | chr8 | 22298971 | + | PSD3 | chr8 | 18662415 | - |
| 5CDS-intron | ENST00000289963 | ENST00000523619 | PPP3CC | chr8 | 22298971 | + | PSD3 | chr8 | 18662415 | - |
| 5CDS-intron | ENST00000289963 | ENST00000520789 | PPP3CC | chr8 | 22298971 | + | PSD3 | chr8 | 18662415 | - |
| 5CDS-intron | ENST00000397775 | ENST00000327040 | PPP3CC | chr8 | 22298971 | + | PSD3 | chr8 | 18662415 | - |
| 5CDS-intron | ENST00000397775 | ENST00000440756 | PPP3CC | chr8 | 22298971 | + | PSD3 | chr8 | 18662415 | - |
| 5CDS-intron | ENST00000397775 | ENST00000286485 | PPP3CC | chr8 | 22298971 | + | PSD3 | chr8 | 18662415 | - |
| 5CDS-intron | ENST00000397775 | ENST00000428502 | PPP3CC | chr8 | 22298971 | + | PSD3 | chr8 | 18662415 | - |
| 5CDS-intron | ENST00000397775 | ENST00000523619 | PPP3CC | chr8 | 22298971 | + | PSD3 | chr8 | 18662415 | - |
| 5CDS-intron | ENST00000397775 | ENST00000520789 | PPP3CC | chr8 | 22298971 | + | PSD3 | chr8 | 18662415 | - |
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FusionProtFeatures for PPP3CC_PSD3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PPP3CC | PSD3 |