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Fusion gene ID: 28475 |
FusionGeneSummary for PPP3CA_PPP3CA |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PPP3CA_PPP3CA | Fusion gene ID: 28475 | Hgene | Tgene | Gene symbol | PPP3CA | PPP3CA | Gene ID | 5530 | 5530 |
| Gene name | protein phosphatase 3 catalytic subunit alpha | protein phosphatase 3 catalytic subunit alpha | |
| Synonyms | CALN|CALNA|CALNA1|CCN1|CNA1|IECEE|IECEE1|PPP2B | CALN|CALNA|CALNA1|CCN1|CNA1|IECEE|IECEE1|PPP2B | |
| Cytomap | 4q24 | 4q24 | |
| Type of gene | protein-coding | protein-coding | |
| Description | serine/threonine-protein phosphatase 2B catalytic subunit alpha isoformCAM-PRP catalytic subunitcalcineurin A alphacalmodulin-dependent calcineurin A subunit alpha isoformprotein phosphatase 2B, catalytic subunit, alpha isoformprotein phosphatase 3 ( | serine/threonine-protein phosphatase 2B catalytic subunit alpha isoformCAM-PRP catalytic subunitcalcineurin A alphacalmodulin-dependent calcineurin A subunit alpha isoformprotein phosphatase 2B, catalytic subunit, alpha isoformprotein phosphatase 3 ( | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q08209 | Q08209 | |
| Ensembl transtripts involved in fusion gene | ENST00000512215, ENST00000394854, ENST00000323055, ENST00000394853, ENST00000507176, ENST00000523694, ENST00000510292, | ENST00000512215, ENST00000394854, ENST00000323055, ENST00000394853, ENST00000507176, ENST00000523694, ENST00000510292, | |
| Fusion gene scores | * DoF score | 11 X 7 X 5=385 | 8 X 5 X 3=120 |
| # samples | 9 | 8 | |
| ** MAII score | log2(9/385*10)=-2.09686153925259 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/120*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: PPP3CA [Title/Abstract] AND PPP3CA [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | PPP3CA | GO:0006470 | protein dephosphorylation | 18815128|19154138 |
| Hgene | PPP3CA | GO:0033173 | calcineurin-NFAT signaling cascade | 19154138|22688515 |
| Hgene | PPP3CA | GO:0035690 | cellular response to drug | 11005320 |
| Hgene | PPP3CA | GO:0045944 | positive regulation of transcription by RNA polymerase II | 22688515 |
| Hgene | PPP3CA | GO:0051592 | response to calcium ion | 18815128 |
| Tgene | PPP3CA | GO:0006470 | protein dephosphorylation | 18815128|19154138 |
| Tgene | PPP3CA | GO:0033173 | calcineurin-NFAT signaling cascade | 19154138|22688515 |
| Tgene | PPP3CA | GO:0035690 | cellular response to drug | 11005320 |
| Tgene | PPP3CA | GO:0045944 | positive regulation of transcription by RNA polymerase II | 22688515 |
| Tgene | PPP3CA | GO:0051592 | response to calcium ion | 18815128 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | CA312092 | PPP3CA | chr4 | 101946816 | + | PPP3CA | chr4 | 101946763 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3UTR | ENST00000512215 | ENST00000512215 | PPP3CA | chr4 | 101946816 | + | PPP3CA | chr4 | 101946763 | - |
| intron-3UTR | ENST00000512215 | ENST00000394854 | PPP3CA | chr4 | 101946816 | + | PPP3CA | chr4 | 101946763 | - |
| intron-3UTR | ENST00000512215 | ENST00000323055 | PPP3CA | chr4 | 101946816 | + | PPP3CA | chr4 | 101946763 | - |
| intron-3UTR | ENST00000512215 | ENST00000394853 | PPP3CA | chr4 | 101946816 | + | PPP3CA | chr4 | 101946763 | - |
| intron-3UTR | ENST00000512215 | ENST00000507176 | PPP3CA | chr4 | 101946816 | + | PPP3CA | chr4 | 101946763 | - |
| intron-intron | ENST00000512215 | ENST00000523694 | PPP3CA | chr4 | 101946816 | + | PPP3CA | chr4 | 101946763 | - |
| intron-intron | ENST00000512215 | ENST00000510292 | PPP3CA | chr4 | 101946816 | + | PPP3CA | chr4 | 101946763 | - |
| intron-3UTR | ENST00000394854 | ENST00000512215 | PPP3CA | chr4 | 101946816 | + | PPP3CA | chr4 | 101946763 | - |
| intron-3UTR | ENST00000394854 | ENST00000394854 | PPP3CA | chr4 | 101946816 | + | PPP3CA | chr4 | 101946763 | - |
| intron-3UTR | ENST00000394854 | ENST00000323055 | PPP3CA | chr4 | 101946816 | + | PPP3CA | chr4 | 101946763 | - |
| intron-3UTR | ENST00000394854 | ENST00000394853 | PPP3CA | chr4 | 101946816 | + | PPP3CA | chr4 | 101946763 | - |
| intron-3UTR | ENST00000394854 | ENST00000507176 | PPP3CA | chr4 | 101946816 | + | PPP3CA | chr4 | 101946763 | - |
| intron-intron | ENST00000394854 | ENST00000523694 | PPP3CA | chr4 | 101946816 | + | PPP3CA | chr4 | 101946763 | - |
| intron-intron | ENST00000394854 | ENST00000510292 | PPP3CA | chr4 | 101946816 | + | PPP3CA | chr4 | 101946763 | - |
| intron-3UTR | ENST00000323055 | ENST00000512215 | PPP3CA | chr4 | 101946816 | + | PPP3CA | chr4 | 101946763 | - |
| intron-3UTR | ENST00000323055 | ENST00000394854 | PPP3CA | chr4 | 101946816 | + | PPP3CA | chr4 | 101946763 | - |
| intron-3UTR | ENST00000323055 | ENST00000323055 | PPP3CA | chr4 | 101946816 | + | PPP3CA | chr4 | 101946763 | - |
| intron-3UTR | ENST00000323055 | ENST00000394853 | PPP3CA | chr4 | 101946816 | + | PPP3CA | chr4 | 101946763 | - |
| intron-3UTR | ENST00000323055 | ENST00000507176 | PPP3CA | chr4 | 101946816 | + | PPP3CA | chr4 | 101946763 | - |
| intron-intron | ENST00000323055 | ENST00000523694 | PPP3CA | chr4 | 101946816 | + | PPP3CA | chr4 | 101946763 | - |
| intron-intron | ENST00000323055 | ENST00000510292 | PPP3CA | chr4 | 101946816 | + | PPP3CA | chr4 | 101946763 | - |
| intron-3UTR | ENST00000394853 | ENST00000512215 | PPP3CA | chr4 | 101946816 | + | PPP3CA | chr4 | 101946763 | - |
| intron-3UTR | ENST00000394853 | ENST00000394854 | PPP3CA | chr4 | 101946816 | + | PPP3CA | chr4 | 101946763 | - |
| intron-3UTR | ENST00000394853 | ENST00000323055 | PPP3CA | chr4 | 101946816 | + | PPP3CA | chr4 | 101946763 | - |
| intron-3UTR | ENST00000394853 | ENST00000394853 | PPP3CA | chr4 | 101946816 | + | PPP3CA | chr4 | 101946763 | - |
| intron-3UTR | ENST00000394853 | ENST00000507176 | PPP3CA | chr4 | 101946816 | + | PPP3CA | chr4 | 101946763 | - |
| intron-intron | ENST00000394853 | ENST00000523694 | PPP3CA | chr4 | 101946816 | + | PPP3CA | chr4 | 101946763 | - |
| intron-intron | ENST00000394853 | ENST00000510292 | PPP3CA | chr4 | 101946816 | + | PPP3CA | chr4 | 101946763 | - |
| intron-3UTR | ENST00000507176 | ENST00000512215 | PPP3CA | chr4 | 101946816 | + | PPP3CA | chr4 | 101946763 | - |
| intron-3UTR | ENST00000507176 | ENST00000394854 | PPP3CA | chr4 | 101946816 | + | PPP3CA | chr4 | 101946763 | - |
| intron-3UTR | ENST00000507176 | ENST00000323055 | PPP3CA | chr4 | 101946816 | + | PPP3CA | chr4 | 101946763 | - |
| intron-3UTR | ENST00000507176 | ENST00000394853 | PPP3CA | chr4 | 101946816 | + | PPP3CA | chr4 | 101946763 | - |
| intron-3UTR | ENST00000507176 | ENST00000507176 | PPP3CA | chr4 | 101946816 | + | PPP3CA | chr4 | 101946763 | - |
| intron-intron | ENST00000507176 | ENST00000523694 | PPP3CA | chr4 | 101946816 | + | PPP3CA | chr4 | 101946763 | - |
| intron-intron | ENST00000507176 | ENST00000510292 | PPP3CA | chr4 | 101946816 | + | PPP3CA | chr4 | 101946763 | - |
| intron-3UTR | ENST00000523694 | ENST00000512215 | PPP3CA | chr4 | 101946816 | + | PPP3CA | chr4 | 101946763 | - |
| intron-3UTR | ENST00000523694 | ENST00000394854 | PPP3CA | chr4 | 101946816 | + | PPP3CA | chr4 | 101946763 | - |
| intron-3UTR | ENST00000523694 | ENST00000323055 | PPP3CA | chr4 | 101946816 | + | PPP3CA | chr4 | 101946763 | - |
| intron-3UTR | ENST00000523694 | ENST00000394853 | PPP3CA | chr4 | 101946816 | + | PPP3CA | chr4 | 101946763 | - |
| intron-3UTR | ENST00000523694 | ENST00000507176 | PPP3CA | chr4 | 101946816 | + | PPP3CA | chr4 | 101946763 | - |
| intron-intron | ENST00000523694 | ENST00000523694 | PPP3CA | chr4 | 101946816 | + | PPP3CA | chr4 | 101946763 | - |
| intron-intron | ENST00000523694 | ENST00000510292 | PPP3CA | chr4 | 101946816 | + | PPP3CA | chr4 | 101946763 | - |
| intron-3UTR | ENST00000510292 | ENST00000512215 | PPP3CA | chr4 | 101946816 | + | PPP3CA | chr4 | 101946763 | - |
| intron-3UTR | ENST00000510292 | ENST00000394854 | PPP3CA | chr4 | 101946816 | + | PPP3CA | chr4 | 101946763 | - |
| intron-3UTR | ENST00000510292 | ENST00000323055 | PPP3CA | chr4 | 101946816 | + | PPP3CA | chr4 | 101946763 | - |
| intron-3UTR | ENST00000510292 | ENST00000394853 | PPP3CA | chr4 | 101946816 | + | PPP3CA | chr4 | 101946763 | - |
| intron-3UTR | ENST00000510292 | ENST00000507176 | PPP3CA | chr4 | 101946816 | + | PPP3CA | chr4 | 101946763 | - |
| intron-intron | ENST00000510292 | ENST00000523694 | PPP3CA | chr4 | 101946816 | + | PPP3CA | chr4 | 101946763 | - |
| intron-intron | ENST00000510292 | ENST00000510292 | PPP3CA | chr4 | 101946816 | + | PPP3CA | chr4 | 101946763 | - |
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FusionProtFeatures for PPP3CA_PPP3CA |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PPP3CA | PPP3CA |