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Fusion gene ID: 28467 |
FusionGeneSummary for PPP3CA_ACTL6A |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PPP3CA_ACTL6A | Fusion gene ID: 28467 | Hgene | Tgene | Gene symbol | PPP3CA | ACTL6A | Gene ID | 5530 | 86 |
| Gene name | protein phosphatase 3 catalytic subunit alpha | actin like 6A | |
| Synonyms | CALN|CALNA|CALNA1|CCN1|CNA1|IECEE|IECEE1|PPP2B | ACTL6|ARPN-BETA|Arp4|BAF53A|INO80K | |
| Cytomap | 4q24 | 3q26.33 | |
| Type of gene | protein-coding | protein-coding | |
| Description | serine/threonine-protein phosphatase 2B catalytic subunit alpha isoformCAM-PRP catalytic subunitcalcineurin A alphacalmodulin-dependent calcineurin A subunit alpha isoformprotein phosphatase 2B, catalytic subunit, alpha isoformprotein phosphatase 3 ( | actin-like protein 6A53 kDa BRG1-associated factor ABAF complex 53 kDa subunitBAF53BRG1-associated factor 53AINO80 complex subunit Kactin-related protein 4actin-related protein Baf53aarpNbetahArpN beta | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q08209 | O96019 | |
| Ensembl transtripts involved in fusion gene | ENST00000512215, ENST00000394854, ENST00000323055, ENST00000394853, ENST00000507176, ENST00000523694, ENST00000510292, | ENST00000429709, ENST00000450518, ENST00000392662, ENST00000467615, | |
| Fusion gene scores | * DoF score | 11 X 7 X 5=385 | 4 X 4 X 2=32 |
| # samples | 9 | 4 | |
| ** MAII score | log2(9/385*10)=-2.09686153925259 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: PPP3CA [Title/Abstract] AND ACTL6A [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | PPP3CA | GO:0006470 | protein dephosphorylation | 18815128|19154138 |
| Hgene | PPP3CA | GO:0033173 | calcineurin-NFAT signaling cascade | 19154138|22688515 |
| Hgene | PPP3CA | GO:0035690 | cellular response to drug | 11005320 |
| Hgene | PPP3CA | GO:0045944 | positive regulation of transcription by RNA polymerase II | 22688515 |
| Hgene | PPP3CA | GO:0051592 | response to calcium ion | 18815128 |
| Tgene | ACTL6A | GO:0006338 | chromatin remodeling | 11726552 |
| Tgene | ACTL6A | GO:0043967 | histone H4 acetylation | 14966270 |
| Tgene | ACTL6A | GO:0043968 | histone H2A acetylation | 14966270 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | DA647290 | PPP3CA | chr4 | 102249607 | - | ACTL6A | chr3 | 179280714 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-5UTR | ENST00000512215 | ENST00000429709 | PPP3CA | chr4 | 102249607 | - | ACTL6A | chr3 | 179280714 | + |
| intron-5UTR | ENST00000512215 | ENST00000450518 | PPP3CA | chr4 | 102249607 | - | ACTL6A | chr3 | 179280714 | + |
| intron-5UTR | ENST00000512215 | ENST00000392662 | PPP3CA | chr4 | 102249607 | - | ACTL6A | chr3 | 179280714 | + |
| intron-intron | ENST00000512215 | ENST00000467615 | PPP3CA | chr4 | 102249607 | - | ACTL6A | chr3 | 179280714 | + |
| intron-5UTR | ENST00000394854 | ENST00000429709 | PPP3CA | chr4 | 102249607 | - | ACTL6A | chr3 | 179280714 | + |
| intron-5UTR | ENST00000394854 | ENST00000450518 | PPP3CA | chr4 | 102249607 | - | ACTL6A | chr3 | 179280714 | + |
| intron-5UTR | ENST00000394854 | ENST00000392662 | PPP3CA | chr4 | 102249607 | - | ACTL6A | chr3 | 179280714 | + |
| intron-intron | ENST00000394854 | ENST00000467615 | PPP3CA | chr4 | 102249607 | - | ACTL6A | chr3 | 179280714 | + |
| intron-5UTR | ENST00000323055 | ENST00000429709 | PPP3CA | chr4 | 102249607 | - | ACTL6A | chr3 | 179280714 | + |
| intron-5UTR | ENST00000323055 | ENST00000450518 | PPP3CA | chr4 | 102249607 | - | ACTL6A | chr3 | 179280714 | + |
| intron-5UTR | ENST00000323055 | ENST00000392662 | PPP3CA | chr4 | 102249607 | - | ACTL6A | chr3 | 179280714 | + |
| intron-intron | ENST00000323055 | ENST00000467615 | PPP3CA | chr4 | 102249607 | - | ACTL6A | chr3 | 179280714 | + |
| intron-5UTR | ENST00000394853 | ENST00000429709 | PPP3CA | chr4 | 102249607 | - | ACTL6A | chr3 | 179280714 | + |
| intron-5UTR | ENST00000394853 | ENST00000450518 | PPP3CA | chr4 | 102249607 | - | ACTL6A | chr3 | 179280714 | + |
| intron-5UTR | ENST00000394853 | ENST00000392662 | PPP3CA | chr4 | 102249607 | - | ACTL6A | chr3 | 179280714 | + |
| intron-intron | ENST00000394853 | ENST00000467615 | PPP3CA | chr4 | 102249607 | - | ACTL6A | chr3 | 179280714 | + |
| intron-5UTR | ENST00000507176 | ENST00000429709 | PPP3CA | chr4 | 102249607 | - | ACTL6A | chr3 | 179280714 | + |
| intron-5UTR | ENST00000507176 | ENST00000450518 | PPP3CA | chr4 | 102249607 | - | ACTL6A | chr3 | 179280714 | + |
| intron-5UTR | ENST00000507176 | ENST00000392662 | PPP3CA | chr4 | 102249607 | - | ACTL6A | chr3 | 179280714 | + |
| intron-intron | ENST00000507176 | ENST00000467615 | PPP3CA | chr4 | 102249607 | - | ACTL6A | chr3 | 179280714 | + |
| intron-5UTR | ENST00000523694 | ENST00000429709 | PPP3CA | chr4 | 102249607 | - | ACTL6A | chr3 | 179280714 | + |
| intron-5UTR | ENST00000523694 | ENST00000450518 | PPP3CA | chr4 | 102249607 | - | ACTL6A | chr3 | 179280714 | + |
| intron-5UTR | ENST00000523694 | ENST00000392662 | PPP3CA | chr4 | 102249607 | - | ACTL6A | chr3 | 179280714 | + |
| intron-intron | ENST00000523694 | ENST00000467615 | PPP3CA | chr4 | 102249607 | - | ACTL6A | chr3 | 179280714 | + |
| intron-5UTR | ENST00000510292 | ENST00000429709 | PPP3CA | chr4 | 102249607 | - | ACTL6A | chr3 | 179280714 | + |
| intron-5UTR | ENST00000510292 | ENST00000450518 | PPP3CA | chr4 | 102249607 | - | ACTL6A | chr3 | 179280714 | + |
| intron-5UTR | ENST00000510292 | ENST00000392662 | PPP3CA | chr4 | 102249607 | - | ACTL6A | chr3 | 179280714 | + |
| intron-intron | ENST00000510292 | ENST00000467615 | PPP3CA | chr4 | 102249607 | - | ACTL6A | chr3 | 179280714 | + |
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FusionProtFeatures for PPP3CA_ACTL6A |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PPP3CA | ACTL6A |