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Fusion gene ID: 28462 |
FusionGeneSummary for PPP2R5E_MBIP |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PPP2R5E_MBIP | Fusion gene ID: 28462 | Hgene | Tgene | Gene symbol | PPP2R5E | MBIP | Gene ID | 5529 | 51562 |
| Gene name | protein phosphatase 2 regulatory subunit B'epsilon | MAP3K12 binding inhibitory protein 1 | |
| Synonyms | B56E|B56epsilon | - | |
| Cytomap | 14q23.2 | 14q13.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoformPP2A, B subunit, B' epsilonPP2A, B subunit, B56 epsilonPP2A, B subunit, PR61 epsilonPP2A, B subunit, R5 epsilonepsilon isoform of regulatory subunit B56, protein phospha | MAP3K12-binding inhibitory protein 1MAPK upstream kinase-binding inhibitory proteinMUK-binding inhibitory protein | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q16537 | Q9NS73 | |
| Ensembl transtripts involved in fusion gene | ENST00000337537, ENST00000555899, ENST00000422769, ENST00000553266, | ENST00000416007, ENST00000318473, ENST00000359527, ENST00000603913, | |
| Fusion gene scores | * DoF score | 7 X 5 X 5=175 | 1 X 1 X 1=1 |
| # samples | 7 | 1 | |
| ** MAII score | log2(7/175*10)=-1.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: PPP2R5E [Title/Abstract] AND MBIP [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | MBIP | GO:0043966 | histone H3 acetylation | 18838386 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LIHC | TCGA-GJ-A9DB-01A | PPP2R5E | chr14 | 64006247 | - | MBIP | chr14 | 36784121 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000337537 | ENST00000416007 | PPP2R5E | chr14 | 64006247 | - | MBIP | chr14 | 36784121 | - |
| Frame-shift | ENST00000337537 | ENST00000318473 | PPP2R5E | chr14 | 64006247 | - | MBIP | chr14 | 36784121 | - |
| Frame-shift | ENST00000337537 | ENST00000359527 | PPP2R5E | chr14 | 64006247 | - | MBIP | chr14 | 36784121 | - |
| 5CDS-intron | ENST00000337537 | ENST00000603913 | PPP2R5E | chr14 | 64006247 | - | MBIP | chr14 | 36784121 | - |
| Frame-shift | ENST00000555899 | ENST00000416007 | PPP2R5E | chr14 | 64006247 | - | MBIP | chr14 | 36784121 | - |
| Frame-shift | ENST00000555899 | ENST00000318473 | PPP2R5E | chr14 | 64006247 | - | MBIP | chr14 | 36784121 | - |
| Frame-shift | ENST00000555899 | ENST00000359527 | PPP2R5E | chr14 | 64006247 | - | MBIP | chr14 | 36784121 | - |
| 5CDS-intron | ENST00000555899 | ENST00000603913 | PPP2R5E | chr14 | 64006247 | - | MBIP | chr14 | 36784121 | - |
| intron-3CDS | ENST00000422769 | ENST00000416007 | PPP2R5E | chr14 | 64006247 | - | MBIP | chr14 | 36784121 | - |
| intron-3CDS | ENST00000422769 | ENST00000318473 | PPP2R5E | chr14 | 64006247 | - | MBIP | chr14 | 36784121 | - |
| intron-3CDS | ENST00000422769 | ENST00000359527 | PPP2R5E | chr14 | 64006247 | - | MBIP | chr14 | 36784121 | - |
| intron-intron | ENST00000422769 | ENST00000603913 | PPP2R5E | chr14 | 64006247 | - | MBIP | chr14 | 36784121 | - |
| 5UTR-3CDS | ENST00000553266 | ENST00000416007 | PPP2R5E | chr14 | 64006247 | - | MBIP | chr14 | 36784121 | - |
| 5UTR-3CDS | ENST00000553266 | ENST00000318473 | PPP2R5E | chr14 | 64006247 | - | MBIP | chr14 | 36784121 | - |
| 5UTR-3CDS | ENST00000553266 | ENST00000359527 | PPP2R5E | chr14 | 64006247 | - | MBIP | chr14 | 36784121 | - |
| 5UTR-intron | ENST00000553266 | ENST00000603913 | PPP2R5E | chr14 | 64006247 | - | MBIP | chr14 | 36784121 | - |
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FusionProtFeatures for PPP2R5E_MBIP |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PPP2R5E | MBIP |