|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 28441 |
FusionGeneSummary for PPP2R3C_NFKBIA |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PPP2R3C_NFKBIA | Fusion gene ID: 28441 | Hgene | Tgene | Gene symbol | PPP2R3C | NFKBIA | Gene ID | 55012 | 4792 |
| Gene name | protein phosphatase 2 regulatory subunit B''gamma | NFKB inhibitor alpha | |
| Synonyms | C14orf10|G4-1|G5pr | IKBA|MAD-3|NFKBI | |
| Cytomap | 14q13.2 | 14q13.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gammaprotein phosphatase 2 (formerly 2A), regulatory subunit B''protein phosphatase 2, regulatory subunit B'', gammaprotein phosphatase subunit G5PRrhabdomyosarcoma antigen MU-RMS- | NF-kappa-B inhibitor alphaI-kappa-B-alphaIkappaBalphaikB-alphamajor histocompatibility complex enhancer-binding protein MAD3nuclear factor of kappa light chain gene enhancer in B-cellsnuclear factor of kappa light polypeptide gene enhancer in B-cell | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | Q969Q6 | P25963 | |
| Ensembl transtripts involved in fusion gene | ENST00000261475, ENST00000555644, | ENST00000216797, ENST00000557140, ENST00000557389, ENST00000557100, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 3 X 3 X 2=18 |
| # samples | 2 | 3 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: PPP2R3C [Title/Abstract] AND NFKBIA [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | NFKBIA | GO:0007249 | I-kappaB kinase/NF-kappaB signaling | 25038658 |
| Tgene | NFKBIA | GO:0032088 | negative regulation of NF-kappaB transcription factor activity | 11931770 |
| Tgene | NFKBIA | GO:0033209 | tumor necrosis factor-mediated signaling pathway | 25038658 |
| Tgene | NFKBIA | GO:0042994 | cytoplasmic sequestering of transcription factor | 1493333 |
| Tgene | NFKBIA | GO:0045944 | positive regulation of transcription by RNA polymerase II | 19245366 |
| Tgene | NFKBIA | GO:0050729 | positive regulation of inflammatory response | 25038658 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-A8-A07U-01A | PPP2R3C | chr14 | 35557157 | - | NFKBIA | chr14 | 35871266 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000261475 | ENST00000216797 | PPP2R3C | chr14 | 35557157 | - | NFKBIA | chr14 | 35871266 | - |
| Frame-shift | ENST00000261475 | ENST00000557140 | PPP2R3C | chr14 | 35557157 | - | NFKBIA | chr14 | 35871266 | - |
| Frame-shift | ENST00000261475 | ENST00000557389 | PPP2R3C | chr14 | 35557157 | - | NFKBIA | chr14 | 35871266 | - |
| 5CDS-intron | ENST00000261475 | ENST00000557100 | PPP2R3C | chr14 | 35557157 | - | NFKBIA | chr14 | 35871266 | - |
| intron-3CDS | ENST00000555644 | ENST00000216797 | PPP2R3C | chr14 | 35557157 | - | NFKBIA | chr14 | 35871266 | - |
| intron-3CDS | ENST00000555644 | ENST00000557140 | PPP2R3C | chr14 | 35557157 | - | NFKBIA | chr14 | 35871266 | - |
| intron-3CDS | ENST00000555644 | ENST00000557389 | PPP2R3C | chr14 | 35557157 | - | NFKBIA | chr14 | 35871266 | - |
| intron-intron | ENST00000555644 | ENST00000557100 | PPP2R3C | chr14 | 35557157 | - | NFKBIA | chr14 | 35871266 | - |
Top |
FusionProtFeatures for PPP2R3C_NFKBIA |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PPP2R3C | NFKBIA |