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Fusion gene ID: 28433 |
FusionGeneSummary for PPP2R2C_CDK5RAP1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PPP2R2C_CDK5RAP1 | Fusion gene ID: 28433 | Hgene | Tgene | Gene symbol | PPP2R2C | CDK5RAP1 | Gene ID | 5522 | 51654 |
| Gene name | protein phosphatase 2 regulatory subunit Bgamma | CDK5 regulatory subunit associated protein 1 | |
| Synonyms | B55-GAMMA|B55gamma|IMYPNO|IMYPNO1|PR52|PR55G | C20orf34|C42|CGI-05|HSPC167 | |
| Cytomap | 4p16.1 | 20q11.21 | |
| Type of gene | protein-coding | protein-coding | |
| Description | protein phosphatase 2, regulatory subunit B, gammaPP2A, subunit B, B-gamma isoformPP2A, subunit B, B55-gamma isoformPP2A, subunit B, PR55-gamma isoformPP2A, subunit B, R2-gamma isoformgamma isoform of regulatory subunit B55, protein phosphatase 2pho | CDK5 regulatory subunit-associated protein 1CDK5 activator-binding protein C42 | |
| Modification date | 20180527 | 20180523 | |
| UniProtAcc | Q9Y2T4 | Q96SZ6 | |
| Ensembl transtripts involved in fusion gene | ENST00000506140, ENST00000515571, ENST00000382599, ENST00000507294, ENST00000314348, ENST00000335585, | ENST00000473997, ENST00000346416, ENST00000339269, ENST00000357886, ENST00000544843, ENST00000477105, | |
| Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 6 X 4 X 6=144 |
| # samples | 3 | 6 | |
| ** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(6/144*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: PPP2R2C [Title/Abstract] AND CDK5RAP1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | CDK5RAP1 | GO:0045736 | negative regulation of cyclin-dependent protein serine/threonine kinase activity | 11882646 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AA319710 | PPP2R2C | chr4 | 6325065 | - | CDK5RAP1 | chr20 | 31954692 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000506140 | ENST00000473997 | PPP2R2C | chr4 | 6325065 | - | CDK5RAP1 | chr20 | 31954692 | - |
| intron-3CDS | ENST00000506140 | ENST00000346416 | PPP2R2C | chr4 | 6325065 | - | CDK5RAP1 | chr20 | 31954692 | - |
| intron-3CDS | ENST00000506140 | ENST00000339269 | PPP2R2C | chr4 | 6325065 | - | CDK5RAP1 | chr20 | 31954692 | - |
| intron-3CDS | ENST00000506140 | ENST00000357886 | PPP2R2C | chr4 | 6325065 | - | CDK5RAP1 | chr20 | 31954692 | - |
| intron-3UTR | ENST00000506140 | ENST00000544843 | PPP2R2C | chr4 | 6325065 | - | CDK5RAP1 | chr20 | 31954692 | - |
| intron-intron | ENST00000506140 | ENST00000477105 | PPP2R2C | chr4 | 6325065 | - | CDK5RAP1 | chr20 | 31954692 | - |
| intron-3CDS | ENST00000515571 | ENST00000473997 | PPP2R2C | chr4 | 6325065 | - | CDK5RAP1 | chr20 | 31954692 | - |
| intron-3CDS | ENST00000515571 | ENST00000346416 | PPP2R2C | chr4 | 6325065 | - | CDK5RAP1 | chr20 | 31954692 | - |
| intron-3CDS | ENST00000515571 | ENST00000339269 | PPP2R2C | chr4 | 6325065 | - | CDK5RAP1 | chr20 | 31954692 | - |
| intron-3CDS | ENST00000515571 | ENST00000357886 | PPP2R2C | chr4 | 6325065 | - | CDK5RAP1 | chr20 | 31954692 | - |
| intron-3UTR | ENST00000515571 | ENST00000544843 | PPP2R2C | chr4 | 6325065 | - | CDK5RAP1 | chr20 | 31954692 | - |
| intron-intron | ENST00000515571 | ENST00000477105 | PPP2R2C | chr4 | 6325065 | - | CDK5RAP1 | chr20 | 31954692 | - |
| intron-3CDS | ENST00000382599 | ENST00000473997 | PPP2R2C | chr4 | 6325065 | - | CDK5RAP1 | chr20 | 31954692 | - |
| intron-3CDS | ENST00000382599 | ENST00000346416 | PPP2R2C | chr4 | 6325065 | - | CDK5RAP1 | chr20 | 31954692 | - |
| intron-3CDS | ENST00000382599 | ENST00000339269 | PPP2R2C | chr4 | 6325065 | - | CDK5RAP1 | chr20 | 31954692 | - |
| intron-3CDS | ENST00000382599 | ENST00000357886 | PPP2R2C | chr4 | 6325065 | - | CDK5RAP1 | chr20 | 31954692 | - |
| intron-3UTR | ENST00000382599 | ENST00000544843 | PPP2R2C | chr4 | 6325065 | - | CDK5RAP1 | chr20 | 31954692 | - |
| intron-intron | ENST00000382599 | ENST00000477105 | PPP2R2C | chr4 | 6325065 | - | CDK5RAP1 | chr20 | 31954692 | - |
| intron-3CDS | ENST00000507294 | ENST00000473997 | PPP2R2C | chr4 | 6325065 | - | CDK5RAP1 | chr20 | 31954692 | - |
| intron-3CDS | ENST00000507294 | ENST00000346416 | PPP2R2C | chr4 | 6325065 | - | CDK5RAP1 | chr20 | 31954692 | - |
| intron-3CDS | ENST00000507294 | ENST00000339269 | PPP2R2C | chr4 | 6325065 | - | CDK5RAP1 | chr20 | 31954692 | - |
| intron-3CDS | ENST00000507294 | ENST00000357886 | PPP2R2C | chr4 | 6325065 | - | CDK5RAP1 | chr20 | 31954692 | - |
| intron-3UTR | ENST00000507294 | ENST00000544843 | PPP2R2C | chr4 | 6325065 | - | CDK5RAP1 | chr20 | 31954692 | - |
| intron-intron | ENST00000507294 | ENST00000477105 | PPP2R2C | chr4 | 6325065 | - | CDK5RAP1 | chr20 | 31954692 | - |
| intron-3CDS | ENST00000314348 | ENST00000473997 | PPP2R2C | chr4 | 6325065 | - | CDK5RAP1 | chr20 | 31954692 | - |
| intron-3CDS | ENST00000314348 | ENST00000346416 | PPP2R2C | chr4 | 6325065 | - | CDK5RAP1 | chr20 | 31954692 | - |
| intron-3CDS | ENST00000314348 | ENST00000339269 | PPP2R2C | chr4 | 6325065 | - | CDK5RAP1 | chr20 | 31954692 | - |
| intron-3CDS | ENST00000314348 | ENST00000357886 | PPP2R2C | chr4 | 6325065 | - | CDK5RAP1 | chr20 | 31954692 | - |
| intron-3UTR | ENST00000314348 | ENST00000544843 | PPP2R2C | chr4 | 6325065 | - | CDK5RAP1 | chr20 | 31954692 | - |
| intron-intron | ENST00000314348 | ENST00000477105 | PPP2R2C | chr4 | 6325065 | - | CDK5RAP1 | chr20 | 31954692 | - |
| intron-3CDS | ENST00000335585 | ENST00000473997 | PPP2R2C | chr4 | 6325065 | - | CDK5RAP1 | chr20 | 31954692 | - |
| intron-3CDS | ENST00000335585 | ENST00000346416 | PPP2R2C | chr4 | 6325065 | - | CDK5RAP1 | chr20 | 31954692 | - |
| intron-3CDS | ENST00000335585 | ENST00000339269 | PPP2R2C | chr4 | 6325065 | - | CDK5RAP1 | chr20 | 31954692 | - |
| intron-3CDS | ENST00000335585 | ENST00000357886 | PPP2R2C | chr4 | 6325065 | - | CDK5RAP1 | chr20 | 31954692 | - |
| intron-3UTR | ENST00000335585 | ENST00000544843 | PPP2R2C | chr4 | 6325065 | - | CDK5RAP1 | chr20 | 31954692 | - |
| intron-intron | ENST00000335585 | ENST00000477105 | PPP2R2C | chr4 | 6325065 | - | CDK5RAP1 | chr20 | 31954692 | - |
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FusionProtFeatures for PPP2R2C_CDK5RAP1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PPP2R2C | CDK5RAP1 |