|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 28430 |
FusionGeneSummary for PPP2R2B_CCT3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PPP2R2B_CCT3 | Fusion gene ID: 28430 | Hgene | Tgene | Gene symbol | PPP2R2B | CCT3 | Gene ID | 5521 | 7203 |
| Gene name | protein phosphatase 2 regulatory subunit Bbeta | chaperonin containing TCP1 subunit 3 | |
| Synonyms | B55BETA|PP2AB55BETA|PP2ABBETA|PP2APR55B|PP2APR55BETA|PR2AB55BETA|PR2ABBETA|PR2APR55BETA|PR52B|PR55-BETA|PR55BETA|SCA12 | CCT-gamma|CCTG|PIG48|TCP-1-gamma|TRIC5 | |
| Cytomap | 5q32 | 1q22 | |
| Type of gene | protein-coding | protein-coding | |
| Description | serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoformPP2A subunit B isoform B55-betaPP2A subunit B isoform PR55-betaPP2A subunit B isoform R2-betaPP2A, subunit B, B-beta isoformprotein phosphatase 2 (formerly 2A), regulator | T-complex protein 1 subunit gammaT-complex protein 1, gamma subunitTCP1 (t-complex-1) ring complex, polypeptide 5chaperonin containing TCP1, subunit 3 (gamma)hTRiC5 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q00005 | P49368 | |
| Ensembl transtripts involved in fusion gene | ENST00000394413, ENST00000530902, ENST00000508545, ENST00000394414, ENST00000394411, ENST00000453001, ENST00000356826, ENST00000394410, ENST00000336640, ENST00000504198, ENST00000394409, | ENST00000295688, ENST00000368259, ENST00000368261, ENST00000472765, ENST00000368256, | |
| Fusion gene scores | * DoF score | 3 X 4 X 3=36 | 12 X 8 X 9=864 |
| # samples | 4 | 12 | |
| ** MAII score | log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(12/864*10)=-2.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: PPP2R2B [Title/Abstract] AND CCT3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | GBM | TCGA-41-4097-01A | PPP2R2B | chr5 | 146017814 | - | CCT3 | chr1 | 156294880 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000394413 | ENST00000295688 | PPP2R2B | chr5 | 146017814 | - | CCT3 | chr1 | 156294880 | - |
| In-frame | ENST00000394413 | ENST00000368259 | PPP2R2B | chr5 | 146017814 | - | CCT3 | chr1 | 156294880 | - |
| In-frame | ENST00000394413 | ENST00000368261 | PPP2R2B | chr5 | 146017814 | - | CCT3 | chr1 | 156294880 | - |
| In-frame | ENST00000394413 | ENST00000472765 | PPP2R2B | chr5 | 146017814 | - | CCT3 | chr1 | 156294880 | - |
| 5CDS-intron | ENST00000394413 | ENST00000368256 | PPP2R2B | chr5 | 146017814 | - | CCT3 | chr1 | 156294880 | - |
| 5UTR-3CDS | ENST00000530902 | ENST00000295688 | PPP2R2B | chr5 | 146017814 | - | CCT3 | chr1 | 156294880 | - |
| 5UTR-3CDS | ENST00000530902 | ENST00000368259 | PPP2R2B | chr5 | 146017814 | - | CCT3 | chr1 | 156294880 | - |
| 5UTR-3CDS | ENST00000530902 | ENST00000368261 | PPP2R2B | chr5 | 146017814 | - | CCT3 | chr1 | 156294880 | - |
| 5UTR-3CDS | ENST00000530902 | ENST00000472765 | PPP2R2B | chr5 | 146017814 | - | CCT3 | chr1 | 156294880 | - |
| 5UTR-intron | ENST00000530902 | ENST00000368256 | PPP2R2B | chr5 | 146017814 | - | CCT3 | chr1 | 156294880 | - |
| Frame-shift | ENST00000508545 | ENST00000295688 | PPP2R2B | chr5 | 146017814 | - | CCT3 | chr1 | 156294880 | - |
| Frame-shift | ENST00000508545 | ENST00000368259 | PPP2R2B | chr5 | 146017814 | - | CCT3 | chr1 | 156294880 | - |
| Frame-shift | ENST00000508545 | ENST00000368261 | PPP2R2B | chr5 | 146017814 | - | CCT3 | chr1 | 156294880 | - |
| Frame-shift | ENST00000508545 | ENST00000472765 | PPP2R2B | chr5 | 146017814 | - | CCT3 | chr1 | 156294880 | - |
| 5CDS-intron | ENST00000508545 | ENST00000368256 | PPP2R2B | chr5 | 146017814 | - | CCT3 | chr1 | 156294880 | - |
| In-frame | ENST00000394414 | ENST00000295688 | PPP2R2B | chr5 | 146017814 | - | CCT3 | chr1 | 156294880 | - |
| In-frame | ENST00000394414 | ENST00000368259 | PPP2R2B | chr5 | 146017814 | - | CCT3 | chr1 | 156294880 | - |
| In-frame | ENST00000394414 | ENST00000368261 | PPP2R2B | chr5 | 146017814 | - | CCT3 | chr1 | 156294880 | - |
| In-frame | ENST00000394414 | ENST00000472765 | PPP2R2B | chr5 | 146017814 | - | CCT3 | chr1 | 156294880 | - |
| 5CDS-intron | ENST00000394414 | ENST00000368256 | PPP2R2B | chr5 | 146017814 | - | CCT3 | chr1 | 156294880 | - |
| Frame-shift | ENST00000394411 | ENST00000295688 | PPP2R2B | chr5 | 146017814 | - | CCT3 | chr1 | 156294880 | - |
| Frame-shift | ENST00000394411 | ENST00000368259 | PPP2R2B | chr5 | 146017814 | - | CCT3 | chr1 | 156294880 | - |
| Frame-shift | ENST00000394411 | ENST00000368261 | PPP2R2B | chr5 | 146017814 | - | CCT3 | chr1 | 156294880 | - |
| Frame-shift | ENST00000394411 | ENST00000472765 | PPP2R2B | chr5 | 146017814 | - | CCT3 | chr1 | 156294880 | - |
| 5CDS-intron | ENST00000394411 | ENST00000368256 | PPP2R2B | chr5 | 146017814 | - | CCT3 | chr1 | 156294880 | - |
| Frame-shift | ENST00000453001 | ENST00000295688 | PPP2R2B | chr5 | 146017814 | - | CCT3 | chr1 | 156294880 | - |
| Frame-shift | ENST00000453001 | ENST00000368259 | PPP2R2B | chr5 | 146017814 | - | CCT3 | chr1 | 156294880 | - |
| Frame-shift | ENST00000453001 | ENST00000368261 | PPP2R2B | chr5 | 146017814 | - | CCT3 | chr1 | 156294880 | - |
| Frame-shift | ENST00000453001 | ENST00000472765 | PPP2R2B | chr5 | 146017814 | - | CCT3 | chr1 | 156294880 | - |
| 5CDS-intron | ENST00000453001 | ENST00000368256 | PPP2R2B | chr5 | 146017814 | - | CCT3 | chr1 | 156294880 | - |
| Frame-shift | ENST00000356826 | ENST00000295688 | PPP2R2B | chr5 | 146017814 | - | CCT3 | chr1 | 156294880 | - |
| Frame-shift | ENST00000356826 | ENST00000368259 | PPP2R2B | chr5 | 146017814 | - | CCT3 | chr1 | 156294880 | - |
| Frame-shift | ENST00000356826 | ENST00000368261 | PPP2R2B | chr5 | 146017814 | - | CCT3 | chr1 | 156294880 | - |
| Frame-shift | ENST00000356826 | ENST00000472765 | PPP2R2B | chr5 | 146017814 | - | CCT3 | chr1 | 156294880 | - |
| 5CDS-intron | ENST00000356826 | ENST00000368256 | PPP2R2B | chr5 | 146017814 | - | CCT3 | chr1 | 156294880 | - |
| Frame-shift | ENST00000394410 | ENST00000295688 | PPP2R2B | chr5 | 146017814 | - | CCT3 | chr1 | 156294880 | - |
| Frame-shift | ENST00000394410 | ENST00000368259 | PPP2R2B | chr5 | 146017814 | - | CCT3 | chr1 | 156294880 | - |
| Frame-shift | ENST00000394410 | ENST00000368261 | PPP2R2B | chr5 | 146017814 | - | CCT3 | chr1 | 156294880 | - |
| Frame-shift | ENST00000394410 | ENST00000472765 | PPP2R2B | chr5 | 146017814 | - | CCT3 | chr1 | 156294880 | - |
| 5CDS-intron | ENST00000394410 | ENST00000368256 | PPP2R2B | chr5 | 146017814 | - | CCT3 | chr1 | 156294880 | - |
| In-frame | ENST00000336640 | ENST00000295688 | PPP2R2B | chr5 | 146017814 | - | CCT3 | chr1 | 156294880 | - |
| In-frame | ENST00000336640 | ENST00000368259 | PPP2R2B | chr5 | 146017814 | - | CCT3 | chr1 | 156294880 | - |
| In-frame | ENST00000336640 | ENST00000368261 | PPP2R2B | chr5 | 146017814 | - | CCT3 | chr1 | 156294880 | - |
| In-frame | ENST00000336640 | ENST00000472765 | PPP2R2B | chr5 | 146017814 | - | CCT3 | chr1 | 156294880 | - |
| 5CDS-intron | ENST00000336640 | ENST00000368256 | PPP2R2B | chr5 | 146017814 | - | CCT3 | chr1 | 156294880 | - |
| In-frame | ENST00000504198 | ENST00000295688 | PPP2R2B | chr5 | 146017814 | - | CCT3 | chr1 | 156294880 | - |
| In-frame | ENST00000504198 | ENST00000368259 | PPP2R2B | chr5 | 146017814 | - | CCT3 | chr1 | 156294880 | - |
| In-frame | ENST00000504198 | ENST00000368261 | PPP2R2B | chr5 | 146017814 | - | CCT3 | chr1 | 156294880 | - |
| In-frame | ENST00000504198 | ENST00000472765 | PPP2R2B | chr5 | 146017814 | - | CCT3 | chr1 | 156294880 | - |
| 5CDS-intron | ENST00000504198 | ENST00000368256 | PPP2R2B | chr5 | 146017814 | - | CCT3 | chr1 | 156294880 | - |
| In-frame | ENST00000394409 | ENST00000295688 | PPP2R2B | chr5 | 146017814 | - | CCT3 | chr1 | 156294880 | - |
| In-frame | ENST00000394409 | ENST00000368259 | PPP2R2B | chr5 | 146017814 | - | CCT3 | chr1 | 156294880 | - |
| In-frame | ENST00000394409 | ENST00000368261 | PPP2R2B | chr5 | 146017814 | - | CCT3 | chr1 | 156294880 | - |
| In-frame | ENST00000394409 | ENST00000472765 | PPP2R2B | chr5 | 146017814 | - | CCT3 | chr1 | 156294880 | - |
| 5CDS-intron | ENST00000394409 | ENST00000368256 | PPP2R2B | chr5 | 146017814 | - | CCT3 | chr1 | 156294880 | - |
Top |
FusionProtFeatures for PPP2R2B_CCT3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PPP2R2B | CCT3 |