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Fusion gene ID: 28406 |
FusionGeneSummary for PPP2CB_PURG |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PPP2CB_PURG | Fusion gene ID: 28406 | Hgene | Tgene | Gene symbol | PPP2CB | PURG | Gene ID | 5516 | 29942 |
| Gene name | protein phosphatase 2 catalytic subunit beta | purine rich element binding protein G | |
| Synonyms | PP2Abeta|PP2CB | PURG-A|PURG-B | |
| Cytomap | 8p12 | 8p12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | serine/threonine-protein phosphatase 2A catalytic subunit beta isoformPP2A-betaprotein phosphatase 2 (formerly 2A), catalytic subunit, beta isoformprotein phosphatase 2, catalytic subunit, beta isoformprotein phosphatase 2, catalytic subunit, beta iso | purine-rich element-binding protein gammaPur-gamma | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | P62714 | Q9UJV8 | |
| Ensembl transtripts involved in fusion gene | ENST00000520500, ENST00000221138, ENST00000518564, | ENST00000339382, ENST00000475541, | |
| Fusion gene scores | * DoF score | 4 X 3 X 5=60 | 3 X 2 X 4=24 |
| # samples | 5 | 4 | |
| ** MAII score | log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/24*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: PPP2CB [Title/Abstract] AND PURG [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-A2-A3XZ-01A | PPP2CB | chr8 | 30655097 | - | PURG | chr8 | 30854213 | - |
| TCGA | RV | OV | TCGA-23-1032-01A | PPP2CB | chr8 | 30669836 | - | PURG | chr8 | 30854213 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000520500 | ENST00000339382 | PPP2CB | chr8 | 30655097 | - | PURG | chr8 | 30854213 | - |
| intron-intron | ENST00000520500 | ENST00000475541 | PPP2CB | chr8 | 30655097 | - | PURG | chr8 | 30854213 | - |
| Frame-shift | ENST00000221138 | ENST00000339382 | PPP2CB | chr8 | 30655097 | - | PURG | chr8 | 30854213 | - |
| 5CDS-intron | ENST00000221138 | ENST00000475541 | PPP2CB | chr8 | 30655097 | - | PURG | chr8 | 30854213 | - |
| intron-3CDS | ENST00000518564 | ENST00000339382 | PPP2CB | chr8 | 30655097 | - | PURG | chr8 | 30854213 | - |
| intron-intron | ENST00000518564 | ENST00000475541 | PPP2CB | chr8 | 30655097 | - | PURG | chr8 | 30854213 | - |
| intron-3CDS | ENST00000520500 | ENST00000339382 | PPP2CB | chr8 | 30669836 | - | PURG | chr8 | 30854213 | - |
| intron-intron | ENST00000520500 | ENST00000475541 | PPP2CB | chr8 | 30669836 | - | PURG | chr8 | 30854213 | - |
| Frame-shift | ENST00000221138 | ENST00000339382 | PPP2CB | chr8 | 30669836 | - | PURG | chr8 | 30854213 | - |
| 5CDS-intron | ENST00000221138 | ENST00000475541 | PPP2CB | chr8 | 30669836 | - | PURG | chr8 | 30854213 | - |
| Frame-shift | ENST00000518564 | ENST00000339382 | PPP2CB | chr8 | 30669836 | - | PURG | chr8 | 30854213 | - |
| 5CDS-intron | ENST00000518564 | ENST00000475541 | PPP2CB | chr8 | 30669836 | - | PURG | chr8 | 30854213 | - |
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FusionProtFeatures for PPP2CB_PURG |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PPP2CB | PURG |