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Fusion gene ID: 28377 |
FusionGeneSummary for PPP1R37_RTN2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PPP1R37_RTN2 | Fusion gene ID: 28377 | Hgene | Tgene | Gene symbol | PPP1R37 | RTN2 | Gene ID | 284352 | 6253 |
| Gene name | protein phosphatase 1 regulatory subunit 37 | reticulon 2 | |
| Synonyms | LRRC68 | NSP2|NSPL1|NSPLI|SPG12 | |
| Cytomap | 19q13.32 | 19q13.32 | |
| Type of gene | protein-coding | protein-coding | |
| Description | protein phosphatase 1 regulatory subunit 37leucine rich repeat containing 68leucine-rich repeat-containing protein 68 | reticulon-2NSP-like protein 1NSP-like protein Ineuroendocrine-specific protein-like I | |
| Modification date | 20180519 | 20180522 | |
| UniProtAcc | O75864 | O75298 | |
| Ensembl transtripts involved in fusion gene | ENST00000421905, ENST00000221462, ENST00000496125, | ENST00000245923, ENST00000430715, ENST00000344680, ENST00000590526, ENST00000589384, | |
| Fusion gene scores | * DoF score | 12 X 2 X 9=216 | 2 X 2 X 2=8 |
| # samples | 12 | 2 | |
| ** MAII score | log2(12/216*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: PPP1R37 [Title/Abstract] AND RTN2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | PPP1R37 | GO:0010923 | negative regulation of phosphatase activity | 19389623 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | ESCA | TCGA-JY-A6FD-01A | PPP1R37 | chr19 | 45646891 | + | RTN2 | chr19 | 45989371 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000421905 | ENST00000245923 | PPP1R37 | chr19 | 45646891 | + | RTN2 | chr19 | 45989371 | - |
| In-frame | ENST00000421905 | ENST00000430715 | PPP1R37 | chr19 | 45646891 | + | RTN2 | chr19 | 45989371 | - |
| In-frame | ENST00000421905 | ENST00000344680 | PPP1R37 | chr19 | 45646891 | + | RTN2 | chr19 | 45989371 | - |
| In-frame | ENST00000421905 | ENST00000590526 | PPP1R37 | chr19 | 45646891 | + | RTN2 | chr19 | 45989371 | - |
| 5CDS-intron | ENST00000421905 | ENST00000589384 | PPP1R37 | chr19 | 45646891 | + | RTN2 | chr19 | 45989371 | - |
| In-frame | ENST00000221462 | ENST00000245923 | PPP1R37 | chr19 | 45646891 | + | RTN2 | chr19 | 45989371 | - |
| In-frame | ENST00000221462 | ENST00000430715 | PPP1R37 | chr19 | 45646891 | + | RTN2 | chr19 | 45989371 | - |
| In-frame | ENST00000221462 | ENST00000344680 | PPP1R37 | chr19 | 45646891 | + | RTN2 | chr19 | 45989371 | - |
| In-frame | ENST00000221462 | ENST00000590526 | PPP1R37 | chr19 | 45646891 | + | RTN2 | chr19 | 45989371 | - |
| 5CDS-intron | ENST00000221462 | ENST00000589384 | PPP1R37 | chr19 | 45646891 | + | RTN2 | chr19 | 45989371 | - |
| intron-3CDS | ENST00000496125 | ENST00000245923 | PPP1R37 | chr19 | 45646891 | + | RTN2 | chr19 | 45989371 | - |
| intron-3CDS | ENST00000496125 | ENST00000430715 | PPP1R37 | chr19 | 45646891 | + | RTN2 | chr19 | 45989371 | - |
| intron-3CDS | ENST00000496125 | ENST00000344680 | PPP1R37 | chr19 | 45646891 | + | RTN2 | chr19 | 45989371 | - |
| intron-3CDS | ENST00000496125 | ENST00000590526 | PPP1R37 | chr19 | 45646891 | + | RTN2 | chr19 | 45989371 | - |
| intron-intron | ENST00000496125 | ENST00000589384 | PPP1R37 | chr19 | 45646891 | + | RTN2 | chr19 | 45989371 | - |
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FusionProtFeatures for PPP1R37_RTN2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PPP1R37 | RTN2 |