|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 28341 |
FusionGeneSummary for PPP1R15A_PPP1R15A |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PPP1R15A_PPP1R15A | Fusion gene ID: 28341 | Hgene | Tgene | Gene symbol | PPP1R15A | PPP1R15A | Gene ID | 23645 | 23645 |
| Gene name | protein phosphatase 1 regulatory subunit 15A | protein phosphatase 1 regulatory subunit 15A | |
| Synonyms | GADD34 | GADD34 | |
| Cytomap | 19q13.33 | 19q13.33 | |
| Type of gene | protein-coding | protein-coding | |
| Description | protein phosphatase 1 regulatory subunit 15Agrowth arrest and DNA damage-inducible protein GADD34growth arrest and DNA-damage-inducible 34myeloid differentiation primary response protein MyD116 homologprotein phosphatase 1, regulatory (inhibitor) subu | protein phosphatase 1 regulatory subunit 15Agrowth arrest and DNA damage-inducible protein GADD34growth arrest and DNA-damage-inducible 34myeloid differentiation primary response protein MyD116 homologprotein phosphatase 1, regulatory (inhibitor) subu | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | O75807 | O75807 | |
| Ensembl transtripts involved in fusion gene | ENST00000200453, | ENST00000200453, | |
| Fusion gene scores | * DoF score | 5 X 5 X 2=50 | 3 X 3 X 1=9 |
| # samples | 7 | 3 | |
| ** MAII score | log2(7/50*10)=0.485426827170242 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: PPP1R15A [Title/Abstract] AND PPP1R15A [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | PPP1R15A | GO:0032515 | negative regulation of phosphoprotein phosphatase activity | 11564868 |
| Hgene | PPP1R15A | GO:0032516 | positive regulation of phosphoprotein phosphatase activity | 11564868 |
| Hgene | PPP1R15A | GO:0034976 | response to endoplasmic reticulum stress | 12556489 |
| Hgene | PPP1R15A | GO:0035308 | negative regulation of protein dephosphorylation | 11564868 |
| Hgene | PPP1R15A | GO:0036496 | regulation of translational initiation by eIF2 alpha dephosphorylation | 12556489 |
| Hgene | PPP1R15A | GO:1902310 | positive regulation of peptidyl-serine dephosphorylation | 11564868|12556489|21518769 |
| Hgene | PPP1R15A | GO:1903917 | positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation | 21518769 |
| Tgene | PPP1R15A | GO:0032515 | negative regulation of phosphoprotein phosphatase activity | 11564868 |
| Tgene | PPP1R15A | GO:0032516 | positive regulation of phosphoprotein phosphatase activity | 11564868 |
| Tgene | PPP1R15A | GO:0034976 | response to endoplasmic reticulum stress | 12556489 |
| Tgene | PPP1R15A | GO:0035308 | negative regulation of protein dephosphorylation | 11564868 |
| Tgene | PPP1R15A | GO:0036496 | regulation of translational initiation by eIF2 alpha dephosphorylation | 12556489 |
| Tgene | PPP1R15A | GO:1902310 | positive regulation of peptidyl-serine dephosphorylation | 11564868|12556489|21518769 |
| Tgene | PPP1R15A | GO:1903917 | positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation | 21518769 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BF986247 | PPP1R15A | chr19 | 49378806 | - | PPP1R15A | chr19 | 49377003 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000200453 | ENST00000200453 | PPP1R15A | chr19 | 49378806 | - | PPP1R15A | chr19 | 49377003 | + |
Top |
FusionProtFeatures for PPP1R15A_PPP1R15A |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PPP1R15A | PPP1R15A |