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Fusion gene ID: 2834 |
FusionGeneSummary for ARRB1_GDPD5 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ARRB1_GDPD5 | Fusion gene ID: 2834 | Hgene | Tgene | Gene symbol | ARRB1 | GDPD5 | Gene ID | 408 | 81544 |
| Gene name | arrestin beta 1 | glycerophosphodiester phosphodiesterase domain containing 5 | |
| Synonyms | ARB1|ARR1 | GDE2|PP1665 | |
| Cytomap | 11q13.4 | 11q13.4-q13.5 | |
| Type of gene | protein-coding | protein-coding | |
| Description | beta-arrestin-1arrestin 2non-visual arrestin-2 | glycerophosphodiester phosphodiesterase domain-containing protein 5glycerophosphodiester phosphodiesterase 2 | |
| Modification date | 20180522 | 20180519 | |
| UniProtAcc | P49407 | Q8WTR4 | |
| Ensembl transtripts involved in fusion gene | ENST00000420843, ENST00000393505, ENST00000360025, | ENST00000336898, ENST00000376282, ENST00000529095, ENST00000526177, ENST00000533784, ENST00000529721, ENST00000533805, ENST00000443276, | |
| Fusion gene scores | * DoF score | 15 X 6 X 6=540 | 8 X 7 X 7=392 |
| # samples | 21 | 13 | |
| ** MAII score | log2(21/540*10)=-1.36257007938471 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(13/392*10)=-1.59234203108675 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ARRB1 [Title/Abstract] AND GDPD5 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ARRB1 | GO:0031397 | negative regulation of protein ubiquitination | 16378096 |
| Hgene | ARRB1 | GO:0032088 | negative regulation of NF-kappaB transcription factor activity | 16378096 |
| Hgene | ARRB1 | GO:0032715 | negative regulation of interleukin-6 production | 16378096 |
| Hgene | ARRB1 | GO:0032717 | negative regulation of interleukin-8 production | 16378096 |
| Hgene | ARRB1 | GO:0070374 | positive regulation of ERK1 and ERK2 cascade | 10644702 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-B6-A3ZX-01A | ARRB1 | chr11 | 75062632 | - | GDPD5 | chr11 | 75201365 | - |
| TCGA | RV | BRCA | TCGA-A7-A6VV-01A | ARRB1 | chr11 | 75062632 | - | GDPD5 | chr11 | 75201365 | - |
| TCGA | RV | LUAD | TCGA-MP-A4TC-01A | ARRB1 | chr11 | 74993006 | - | GDPD5 | chr11 | 75173934 | - |
| TCGA | RV | SKCM | TCGA-FS-A1Z4-06A | ARRB1 | chr11 | 75062632 | - | GDPD5 | chr11 | 75173934 | - |
| TCGA | RV | UCS | TCGA-N8-A56S-01A | ARRB1 | chr11 | 74998359 | - | GDPD5 | chr11 | 75173934 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000420843 | ENST00000336898 | ARRB1 | chr11 | 75062632 | - | GDPD5 | chr11 | 75201365 | - |
| 5CDS-5UTR | ENST00000420843 | ENST00000376282 | ARRB1 | chr11 | 75062632 | - | GDPD5 | chr11 | 75201365 | - |
| 5CDS-5UTR | ENST00000420843 | ENST00000529095 | ARRB1 | chr11 | 75062632 | - | GDPD5 | chr11 | 75201365 | - |
| 5CDS-intron | ENST00000420843 | ENST00000526177 | ARRB1 | chr11 | 75062632 | - | GDPD5 | chr11 | 75201365 | - |
| 5CDS-intron | ENST00000420843 | ENST00000533784 | ARRB1 | chr11 | 75062632 | - | GDPD5 | chr11 | 75201365 | - |
| 5CDS-5UTR | ENST00000420843 | ENST00000529721 | ARRB1 | chr11 | 75062632 | - | GDPD5 | chr11 | 75201365 | - |
| 5CDS-intron | ENST00000420843 | ENST00000533805 | ARRB1 | chr11 | 75062632 | - | GDPD5 | chr11 | 75201365 | - |
| 5CDS-intron | ENST00000420843 | ENST00000443276 | ARRB1 | chr11 | 75062632 | - | GDPD5 | chr11 | 75201365 | - |
| 5CDS-5UTR | ENST00000393505 | ENST00000336898 | ARRB1 | chr11 | 75062632 | - | GDPD5 | chr11 | 75201365 | - |
| 5CDS-5UTR | ENST00000393505 | ENST00000376282 | ARRB1 | chr11 | 75062632 | - | GDPD5 | chr11 | 75201365 | - |
| 5CDS-5UTR | ENST00000393505 | ENST00000529095 | ARRB1 | chr11 | 75062632 | - | GDPD5 | chr11 | 75201365 | - |
| 5CDS-intron | ENST00000393505 | ENST00000526177 | ARRB1 | chr11 | 75062632 | - | GDPD5 | chr11 | 75201365 | - |
| 5CDS-intron | ENST00000393505 | ENST00000533784 | ARRB1 | chr11 | 75062632 | - | GDPD5 | chr11 | 75201365 | - |
| 5CDS-5UTR | ENST00000393505 | ENST00000529721 | ARRB1 | chr11 | 75062632 | - | GDPD5 | chr11 | 75201365 | - |
| 5CDS-intron | ENST00000393505 | ENST00000533805 | ARRB1 | chr11 | 75062632 | - | GDPD5 | chr11 | 75201365 | - |
| 5CDS-intron | ENST00000393505 | ENST00000443276 | ARRB1 | chr11 | 75062632 | - | GDPD5 | chr11 | 75201365 | - |
| 5CDS-5UTR | ENST00000360025 | ENST00000336898 | ARRB1 | chr11 | 75062632 | - | GDPD5 | chr11 | 75201365 | - |
| 5CDS-5UTR | ENST00000360025 | ENST00000376282 | ARRB1 | chr11 | 75062632 | - | GDPD5 | chr11 | 75201365 | - |
| 5CDS-5UTR | ENST00000360025 | ENST00000529095 | ARRB1 | chr11 | 75062632 | - | GDPD5 | chr11 | 75201365 | - |
| 5CDS-intron | ENST00000360025 | ENST00000526177 | ARRB1 | chr11 | 75062632 | - | GDPD5 | chr11 | 75201365 | - |
| 5CDS-intron | ENST00000360025 | ENST00000533784 | ARRB1 | chr11 | 75062632 | - | GDPD5 | chr11 | 75201365 | - |
| 5CDS-5UTR | ENST00000360025 | ENST00000529721 | ARRB1 | chr11 | 75062632 | - | GDPD5 | chr11 | 75201365 | - |
| 5CDS-intron | ENST00000360025 | ENST00000533805 | ARRB1 | chr11 | 75062632 | - | GDPD5 | chr11 | 75201365 | - |
| 5CDS-intron | ENST00000360025 | ENST00000443276 | ARRB1 | chr11 | 75062632 | - | GDPD5 | chr11 | 75201365 | - |
| In-frame | ENST00000420843 | ENST00000336898 | ARRB1 | chr11 | 74993006 | - | GDPD5 | chr11 | 75173934 | - |
| 5CDS-intron | ENST00000420843 | ENST00000376282 | ARRB1 | chr11 | 74993006 | - | GDPD5 | chr11 | 75173934 | - |
| 5CDS-intron | ENST00000420843 | ENST00000529095 | ARRB1 | chr11 | 74993006 | - | GDPD5 | chr11 | 75173934 | - |
| 5CDS-intron | ENST00000420843 | ENST00000526177 | ARRB1 | chr11 | 74993006 | - | GDPD5 | chr11 | 75173934 | - |
| 5CDS-intron | ENST00000420843 | ENST00000533784 | ARRB1 | chr11 | 74993006 | - | GDPD5 | chr11 | 75173934 | - |
| 5CDS-intron | ENST00000420843 | ENST00000529721 | ARRB1 | chr11 | 74993006 | - | GDPD5 | chr11 | 75173934 | - |
| 5CDS-intron | ENST00000420843 | ENST00000533805 | ARRB1 | chr11 | 74993006 | - | GDPD5 | chr11 | 75173934 | - |
| 5CDS-intron | ENST00000420843 | ENST00000443276 | ARRB1 | chr11 | 74993006 | - | GDPD5 | chr11 | 75173934 | - |
| In-frame | ENST00000393505 | ENST00000336898 | ARRB1 | chr11 | 74993006 | - | GDPD5 | chr11 | 75173934 | - |
| 5CDS-intron | ENST00000393505 | ENST00000376282 | ARRB1 | chr11 | 74993006 | - | GDPD5 | chr11 | 75173934 | - |
| 5CDS-intron | ENST00000393505 | ENST00000529095 | ARRB1 | chr11 | 74993006 | - | GDPD5 | chr11 | 75173934 | - |
| 5CDS-intron | ENST00000393505 | ENST00000526177 | ARRB1 | chr11 | 74993006 | - | GDPD5 | chr11 | 75173934 | - |
| 5CDS-intron | ENST00000393505 | ENST00000533784 | ARRB1 | chr11 | 74993006 | - | GDPD5 | chr11 | 75173934 | - |
| 5CDS-intron | ENST00000393505 | ENST00000529721 | ARRB1 | chr11 | 74993006 | - | GDPD5 | chr11 | 75173934 | - |
| 5CDS-intron | ENST00000393505 | ENST00000533805 | ARRB1 | chr11 | 74993006 | - | GDPD5 | chr11 | 75173934 | - |
| 5CDS-intron | ENST00000393505 | ENST00000443276 | ARRB1 | chr11 | 74993006 | - | GDPD5 | chr11 | 75173934 | - |
| In-frame | ENST00000360025 | ENST00000336898 | ARRB1 | chr11 | 74993006 | - | GDPD5 | chr11 | 75173934 | - |
| 5CDS-intron | ENST00000360025 | ENST00000376282 | ARRB1 | chr11 | 74993006 | - | GDPD5 | chr11 | 75173934 | - |
| 5CDS-intron | ENST00000360025 | ENST00000529095 | ARRB1 | chr11 | 74993006 | - | GDPD5 | chr11 | 75173934 | - |
| 5CDS-intron | ENST00000360025 | ENST00000526177 | ARRB1 | chr11 | 74993006 | - | GDPD5 | chr11 | 75173934 | - |
| 5CDS-intron | ENST00000360025 | ENST00000533784 | ARRB1 | chr11 | 74993006 | - | GDPD5 | chr11 | 75173934 | - |
| 5CDS-intron | ENST00000360025 | ENST00000529721 | ARRB1 | chr11 | 74993006 | - | GDPD5 | chr11 | 75173934 | - |
| 5CDS-intron | ENST00000360025 | ENST00000533805 | ARRB1 | chr11 | 74993006 | - | GDPD5 | chr11 | 75173934 | - |
| 5CDS-intron | ENST00000360025 | ENST00000443276 | ARRB1 | chr11 | 74993006 | - | GDPD5 | chr11 | 75173934 | - |
| In-frame | ENST00000420843 | ENST00000336898 | ARRB1 | chr11 | 75062632 | - | GDPD5 | chr11 | 75173934 | - |
| 5CDS-intron | ENST00000420843 | ENST00000376282 | ARRB1 | chr11 | 75062632 | - | GDPD5 | chr11 | 75173934 | - |
| 5CDS-intron | ENST00000420843 | ENST00000529095 | ARRB1 | chr11 | 75062632 | - | GDPD5 | chr11 | 75173934 | - |
| 5CDS-intron | ENST00000420843 | ENST00000526177 | ARRB1 | chr11 | 75062632 | - | GDPD5 | chr11 | 75173934 | - |
| 5CDS-intron | ENST00000420843 | ENST00000533784 | ARRB1 | chr11 | 75062632 | - | GDPD5 | chr11 | 75173934 | - |
| 5CDS-intron | ENST00000420843 | ENST00000529721 | ARRB1 | chr11 | 75062632 | - | GDPD5 | chr11 | 75173934 | - |
| 5CDS-intron | ENST00000420843 | ENST00000533805 | ARRB1 | chr11 | 75062632 | - | GDPD5 | chr11 | 75173934 | - |
| 5CDS-intron | ENST00000420843 | ENST00000443276 | ARRB1 | chr11 | 75062632 | - | GDPD5 | chr11 | 75173934 | - |
| In-frame | ENST00000393505 | ENST00000336898 | ARRB1 | chr11 | 75062632 | - | GDPD5 | chr11 | 75173934 | - |
| 5CDS-intron | ENST00000393505 | ENST00000376282 | ARRB1 | chr11 | 75062632 | - | GDPD5 | chr11 | 75173934 | - |
| 5CDS-intron | ENST00000393505 | ENST00000529095 | ARRB1 | chr11 | 75062632 | - | GDPD5 | chr11 | 75173934 | - |
| 5CDS-intron | ENST00000393505 | ENST00000526177 | ARRB1 | chr11 | 75062632 | - | GDPD5 | chr11 | 75173934 | - |
| 5CDS-intron | ENST00000393505 | ENST00000533784 | ARRB1 | chr11 | 75062632 | - | GDPD5 | chr11 | 75173934 | - |
| 5CDS-intron | ENST00000393505 | ENST00000529721 | ARRB1 | chr11 | 75062632 | - | GDPD5 | chr11 | 75173934 | - |
| 5CDS-intron | ENST00000393505 | ENST00000533805 | ARRB1 | chr11 | 75062632 | - | GDPD5 | chr11 | 75173934 | - |
| 5CDS-intron | ENST00000393505 | ENST00000443276 | ARRB1 | chr11 | 75062632 | - | GDPD5 | chr11 | 75173934 | - |
| In-frame | ENST00000360025 | ENST00000336898 | ARRB1 | chr11 | 75062632 | - | GDPD5 | chr11 | 75173934 | - |
| 5CDS-intron | ENST00000360025 | ENST00000376282 | ARRB1 | chr11 | 75062632 | - | GDPD5 | chr11 | 75173934 | - |
| 5CDS-intron | ENST00000360025 | ENST00000529095 | ARRB1 | chr11 | 75062632 | - | GDPD5 | chr11 | 75173934 | - |
| 5CDS-intron | ENST00000360025 | ENST00000526177 | ARRB1 | chr11 | 75062632 | - | GDPD5 | chr11 | 75173934 | - |
| 5CDS-intron | ENST00000360025 | ENST00000533784 | ARRB1 | chr11 | 75062632 | - | GDPD5 | chr11 | 75173934 | - |
| 5CDS-intron | ENST00000360025 | ENST00000529721 | ARRB1 | chr11 | 75062632 | - | GDPD5 | chr11 | 75173934 | - |
| 5CDS-intron | ENST00000360025 | ENST00000533805 | ARRB1 | chr11 | 75062632 | - | GDPD5 | chr11 | 75173934 | - |
| 5CDS-intron | ENST00000360025 | ENST00000443276 | ARRB1 | chr11 | 75062632 | - | GDPD5 | chr11 | 75173934 | - |
| Frame-shift | ENST00000420843 | ENST00000336898 | ARRB1 | chr11 | 74998359 | - | GDPD5 | chr11 | 75173934 | - |
| 5CDS-intron | ENST00000420843 | ENST00000376282 | ARRB1 | chr11 | 74998359 | - | GDPD5 | chr11 | 75173934 | - |
| 5CDS-intron | ENST00000420843 | ENST00000529095 | ARRB1 | chr11 | 74998359 | - | GDPD5 | chr11 | 75173934 | - |
| 5CDS-intron | ENST00000420843 | ENST00000526177 | ARRB1 | chr11 | 74998359 | - | GDPD5 | chr11 | 75173934 | - |
| 5CDS-intron | ENST00000420843 | ENST00000533784 | ARRB1 | chr11 | 74998359 | - | GDPD5 | chr11 | 75173934 | - |
| 5CDS-intron | ENST00000420843 | ENST00000529721 | ARRB1 | chr11 | 74998359 | - | GDPD5 | chr11 | 75173934 | - |
| 5CDS-intron | ENST00000420843 | ENST00000533805 | ARRB1 | chr11 | 74998359 | - | GDPD5 | chr11 | 75173934 | - |
| 5CDS-intron | ENST00000420843 | ENST00000443276 | ARRB1 | chr11 | 74998359 | - | GDPD5 | chr11 | 75173934 | - |
| Frame-shift | ENST00000393505 | ENST00000336898 | ARRB1 | chr11 | 74998359 | - | GDPD5 | chr11 | 75173934 | - |
| 5CDS-intron | ENST00000393505 | ENST00000376282 | ARRB1 | chr11 | 74998359 | - | GDPD5 | chr11 | 75173934 | - |
| 5CDS-intron | ENST00000393505 | ENST00000529095 | ARRB1 | chr11 | 74998359 | - | GDPD5 | chr11 | 75173934 | - |
| 5CDS-intron | ENST00000393505 | ENST00000526177 | ARRB1 | chr11 | 74998359 | - | GDPD5 | chr11 | 75173934 | - |
| 5CDS-intron | ENST00000393505 | ENST00000533784 | ARRB1 | chr11 | 74998359 | - | GDPD5 | chr11 | 75173934 | - |
| 5CDS-intron | ENST00000393505 | ENST00000529721 | ARRB1 | chr11 | 74998359 | - | GDPD5 | chr11 | 75173934 | - |
| 5CDS-intron | ENST00000393505 | ENST00000533805 | ARRB1 | chr11 | 74998359 | - | GDPD5 | chr11 | 75173934 | - |
| 5CDS-intron | ENST00000393505 | ENST00000443276 | ARRB1 | chr11 | 74998359 | - | GDPD5 | chr11 | 75173934 | - |
| Frame-shift | ENST00000360025 | ENST00000336898 | ARRB1 | chr11 | 74998359 | - | GDPD5 | chr11 | 75173934 | - |
| 5CDS-intron | ENST00000360025 | ENST00000376282 | ARRB1 | chr11 | 74998359 | - | GDPD5 | chr11 | 75173934 | - |
| 5CDS-intron | ENST00000360025 | ENST00000529095 | ARRB1 | chr11 | 74998359 | - | GDPD5 | chr11 | 75173934 | - |
| 5CDS-intron | ENST00000360025 | ENST00000526177 | ARRB1 | chr11 | 74998359 | - | GDPD5 | chr11 | 75173934 | - |
| 5CDS-intron | ENST00000360025 | ENST00000533784 | ARRB1 | chr11 | 74998359 | - | GDPD5 | chr11 | 75173934 | - |
| 5CDS-intron | ENST00000360025 | ENST00000529721 | ARRB1 | chr11 | 74998359 | - | GDPD5 | chr11 | 75173934 | - |
| 5CDS-intron | ENST00000360025 | ENST00000533805 | ARRB1 | chr11 | 74998359 | - | GDPD5 | chr11 | 75173934 | - |
| 5CDS-intron | ENST00000360025 | ENST00000443276 | ARRB1 | chr11 | 74998359 | - | GDPD5 | chr11 | 75173934 | - |
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FusionProtFeatures for ARRB1_GDPD5 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ARRB1 | GDPD5 |